DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Irp-1A and aco-1

DIOPT Version :9

Sequence 1:	NP_477371.1	Gene:	Irp-1A / 42689	FlyBaseID:	FBgn0024958	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_509898.1	Gene:	aco-1 / 181324	WormBaseID:	WBGene00000040	Length:	887	Species:	Caenorhabditis elegans

Alignment Length:	883	Identity:	570/883 - (64%)
Similarity:	692/883 - (78%)	Gaps:	13/883 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 NVYKYFDLPSI-DSKYESLPFSIRVLLESAVRNCDNFHVLEKDVQSILGWTPSLKQETSDVEVSF 84
            ||||||||..: |::|..||.||:.|||:|||:||.||||:|||::||.|..|   :.:..|:.|
Worm    15 NVYKYFDLNGLNDARYNELPISIKYLLEAAVRHCDEFHVLKKDVETILDWKNS---QRNQAEIPF 76

  Fly    85 KPARVILQDFTGVPAVVDFAAMRDAVRELGGNPEKINPICPADLVIDHSVQVDFVRSSDALTKNE 149
            ||||||||||||||||||.|||||||:.:|.:|.||||:||.|||||||||||...:.:||.||:
Worm    77 KPARVILQDFTGVPAVVDLAAMRDAVQNMGADPAKINPVCPVDLVIDHSVQVDHYGNLEALAKNQ 141

  Fly   150 SLEFQRNKERFTFLKWGARAFDNMLIVPPGSGIVHQVNLEYLARVVFESDSSADGSKILYPDSVV 214
            |:||:||:|||.|||||::||||:||||||||||||||||||||.||   ...||  :|||||||
Worm   142 SIEFERNRERFNFLKWGSKAFDNLLIVPPGSGIVHQVNLEYLARTVF---VGKDG--VLYPDSVV 201

  Fly   215 GTDSHTTMINGLGVLGWGVGGIEAEAVMLGQSISMLLPEVIGYRLEGKLGPLATSTDLVLTITKH 279
            |||||||||:|.|||||||||||||||||||.|||::||||||.|.|.|....|||||||||||:
Worm   202 GTDSHTTMIDGSGVLGWGVGGIEAEAVMLGQPISMVIPEVIGYELVGTLSDTVTSTDLVLTITKN 266

  Fly   280 LRQLGVVGKFVEFYGPGVAELSIADRATISNMCPEYGATVGYFPIDENTLSYMRQTNRSEKKIDI 344
            ||.||||||||||:|.|||.|||||||||:|||||||||:|:||:|..|:.|:.||.|.......
Worm   267 LRDLGVVGKFVEFFGTGVASLSIADRATIANMCPEYGATIGFFPVDSRTIDYLTQTGRDTDYTQR 331

  Fly   345 IRKYLKATRQLRDYSLVDQDPQYTESVTLDLSTVVTSVSGPKRPHDRVSVSSMCEDFKSCLISPV 409
            :.:|||:.....:::.....|.||.::.|||.:||.||||||||||||.::|:.:||...|...:
Worm   332 VEQYLKSVGMFVNFTDDSYRPTYTTTLKLDLGSVVPSVSGPKRPHDRVELASLAQDFSKGLTDKI 396

  Fly   410 GFKGFAIPPSALAASGEFQWDDGKSYKIGHGSVVIAAITSCTNTSNPSVMLGAGLLAKNAVQKGL 474
            .||.|.:.|.....|.... :.|::.::.||||||||||||||||||||||.|||:||.||:.||
Worm   397 SFKAFGLKPEDATKSVTIT-NHGRTAELTHGSVVIAAITSCTNTSNPSVMLAAGLVAKKAVELGL 460

  Fly   475 SILPYIKTSLSPGSGVVTYYLRESGVIPYLEQLGFDIVGYGCMTCIGNSGPLDENVVNTIEKNGL 539
            ::.||:||||||||||||.||..||::||||::||:|.||||||||||||||||.|...||:|.|
Worm   461 NVQPYVKTSLSPGSGVVTKYLEASGLLPYLEKIGFNIAGYGCMTCIGNSGPLDEPVTKAIEENNL 525

  Fly   540 VCCGVLSGNRNFEGRIHPNTRANYLASPLLVIAYAIAGRVDIDFEIEPLGVDSNGKEVFLRDIWP 604
            |..|||||||||||||||:.||||||||.|.:.|:|.|.|::|.. ..|.|..:|||:.|.||||
Worm   526 VVAGVLSGNRNFEGRIHPHVRANYLASPPLAVLYSIIGNVNVDIN-GVLAVTPDGKEIRLADIWP 589

  Fly   605 TRSEIQEVEHKHVIPAMFQEVYSKIQLGSRDWQTLEVSDSKLYPWSEISTYIKLPPFFEGMTRAL 669
            ||.|:.:.|.:.|.|..|:|||:.|:|||.:||.||....|||||.:.|||||..|||:|||..|
Worm   590 TRKEVAKFEEEFVKPQFFREVYANIELGSTEWQQLECPAVKLYPWDDASTYIKKVPFFDGMTSEL 654

  Fly   670 PKLKGIEKARCLLLLGDSVTTDHISPAGSIARKSPAARYLSERGLTPRDFNSYGSRRGNDAVMAR 734
            |....|..|..||.||||||||||||||||::.|||||:|:.||:||||||:||:|||||.:|||
Worm   655 PSQSDIVNAHVLLNLGDSVTTDHISPAGSISKTSPAARFLAGRGVTPRDFNTYGARRGNDEIMAR 719

  Fly   735 GTFANIRLVNKLASKTGPSTLHVPSGEEMDIFDAAERYASEGTPLVLVVGKDYGSGSSRDWAAKG 799
            |||||||||||||||.||.|||||||||:||||||::|...|.|.:::.||:||.||||||||||
Worm   720 GTFANIRLVNKLASKVGPITLHVPSGEELDIFDAAQKYKDAGIPAIILAGKEYGCGSSRDWAAKG 784

  Fly   800 PFLLGIKAVIAESYERIHRSNLVGMGIIPLQFLPGQSADTLKLSGREVYNIVLPEGELKPGQRIQ 864
            |||.|:|||||||:||||||||:||||||.|:..||:||:|.|:|:|.::|.:|: :|||||.|.
Worm   785 PFLQGVKAVIAESFERIHRSNLIGMGIIPFQYQAGQNADSLGLTGKEQFSIGVPD-DLKPGQLID 848

  Fly   865 VD-ADGNVFETTLRFDTEVDITYYKNGGILNYMIRKML 901
            |: ::|:||:...||||||::|||:|||||.|||||::
Worm   849 VNVSNGSVFQVICRFDTEVELTYYRNGGILQYMIRKLI 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Irp-1A	NP_477371.1	PTZ00092	1..901	CDD:240263	570/881 (65%)
		AcnA_IRP	88..579	CDD:153136	326/490 (67%)
		AcnA_IRP_Swivel	683..852	CDD:238812	124/168 (74%)
aco-1	NP_509898.1	PTZ00092	3..887	CDD:240263	570/883 (65%)
		AcnA_IRP	80..565	CDD:153136	326/490 (67%)
		AcnA_IRP_Swivel	668..835	CDD:238812	123/166 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167732
Domainoid	1	1.000	681	1.000	Domainoid score	I63
eggNOG	1	0.900	-	-		E1_COG1048
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1657
Inparanoid	1	1.050	1143	1.000	Inparanoid score	I110
Isobase	1	0.950	-	0	Normalized mean entropy	S1246
OMA	1	1.010	-	-		QHG61122
OrthoDB	1	1.010	-	-		D190960at2759
OrthoFinder	1	1.000	-	-		FOG0001444
OrthoInspector	1	1.000	-	-		otm14563
orthoMCL	1	0.900	-	-		OOG6_101028
Panther	1	1.100	-	-	O	PTHR11670
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2385
SonicParanoid	1	1.000	-	-		X803
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	16.790