DRSC/TRiP Functional Genomics Resources

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Protein Alignment Irp-1A and Aco2

DIOPT Version :9

Sequence 1:NP_477371.1 Gene:Irp-1A / 42689 FlyBaseID:FBgn0024958 Length:902 Species:Drosophila melanogaster
Sequence 2:NP_542364.1 Gene:Aco2 / 11429 MGIID:87880 Length:780 Species:Mus musculus


Alignment Length:902 Identity:241/902 - (26%)
Similarity:370/902 - (41%) Gaps:199/902 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    29 PSIDSKYESLPFSIRVLLESAVRNCDNFHVLEKDVQSILGWTPSLKQETSDVEVSFKPARVILQD 93
            ||...:|:.|..:|.::.:...|   ...:.||.|...|....:.:.|.....:..:|.||.:||
Mouse    39 PSEYIRYDLLEKNINIVRKRLNR---PLTLSEKIVYGHLDDPANQEIERGKTYLRLRPDRVAMQD 100

  Fly    94 FTGVPAVVDFAAMRDAVRELGGNPEKINPICPADLVIDHSVQV------DFVRSSDALTKNESLE 152
            .|...|::.|.:        .|.|:   ...|:.:..||.::.      |..|:.|.        
Mouse   101 ATAQMAMLQFIS--------SGLPK---VAVPSTIHCDHLIEAQVGGEKDLRRAKDI-------- 146

  Fly   153 FQRNKERFTFL-----KWGARAFDNMLIVPPGSGIVHQVNLEYLARVVFESDSSADGSKILYPD- 211
               |:|.:.||     |:|...:      .|||||:||:.||..|                ||. 
Mouse   147 ---NQEVYNFLATAGAKYGVGFW------RPGSGIIHQIILENYA----------------YPGV 186

  Fly   212 SVVGTDSHTTMINGLGVLGWGVGGIEAEAVMLGQSISMLLPEVIGYRLEGKLGPLATSTDLVLTI 276
            .::||||||....|||.:..||||.:|..||.|....:..|:|||.:|.|.|....:..|::|.:
Mouse   187 LLIGTDSHTPNGGGLGGICIGVGGADAVDVMAGIPWELKCPKVIGVKLTGSLSGWTSPKDVILKV 251

  Fly   277 TKHLRQLGVVGKFVEFYGPGVAELSIADRATISNMCPEYGATVGYFPIDENTLSYMRQTNRSEKK 341
            ...|...|..|..||::||||..:|....|||.||..|.|||...||.:.....|:.:|.|::  
Mouse   252 AGILTVKGGTGAIVEYHGPGVDSISCTGMATICNMGAEIGATTSVFPYNHRMKKYLSKTGRTD-- 314

  Fly   342 IDIIRKYLKATRQLRDYSLVDQDPQYTESVTLDLSTVVTSVSGPKRP---HDRVSVSSMCEDFKS 403
                  ......:.:|:.:.|...||.:.:.::|:.:...::||..|   |....|.::.|.   
Mouse   315 ------IANLAEEFKDHLVPDPGCQYDQVIEINLNELKPHINGPFTPDLAHPVADVGTVAEK--- 370

  Fly   404 CLISPVGFKGFAIPPSALAASGEFQWDDGKSYKIGHGSVVIAAITSCTNTSNPSVMLGAGLLAKN 468
                    :|:.:                        .:.:..|.||||:|...:...|. :||.
Mouse   371 --------EGWPL------------------------DIRVGLIGSCTNSSYEDMGRSAA-VAKQ 402

  Fly   469 AVQKGLSILPYIKTSLSPGSGVVTYYLRESGVIPYLEQLGFDIVGYGCMTCIGNSGPLDENVVNT 533
            |:..||....  :.:::|||..:...:...|....|..:|..::...|..|||.   .|...:..
Mouse   403 ALAHGLKCKS--QFTITPGSEQIRATIERDGYAQILRDVGGIVLANACGPCIGQ---WDRKDIKK 462

  Fly   534 IEKNGLVCCGVLSGNRNFEGR--IHPNTRANYLASPLLVIAYAIAGRVDIDFEIEPLGVDSNGKE 596
            .|||.:    |.|.||||.||  .:|.|.| ::.||.:|.|.||||.:..:.|.:.| ...:||:
Mouse   463 GEKNTI----VTSYNRNFTGRNDANPETHA-FVTSPEIVTALAIAGTLKFNPETDFL-TGKDGKK 521

  Fly   597 VFLRDIWPTRSEIQEVEHKHVIPAMFQEVYS---KIQLGSRDWQTLEVSDSKLYPWSEISTYIKL 658
            ..|.     ..:..|:......|.  |:.|.   |...|.|    ::||     |.|:  ....|
Mouse   522 FKLE-----APDADELPRSDFDPG--QDTYQHPPKDSSGQR----VDVS-----PTSQ--RLQLL 568

  Fly   659 PPF--FEGMTRALPKLKGIEKARCLLLLGDSVTTDHISPAGSIARKSPAARYLSERGLTPRDFNS 721
            .||  ::|        |.:|..:.|:.:....||||||.||.         :|..||......|:
Mouse   569 EPFDKWDG--------KDLEDLQILIKVKGKCTTDHISAAGP---------WLKFRGHLDNISNN 616

  Fly   722 YGSRRGNDAVMARGTFANIRLVNKLASKTGPSTLHVPSGEEMDIFDAAERYASEGTPLVLVVGKD 786
            ......|   :..|...::|  |.:..:.||    ||        |.|..|...|...|::..::
Mouse   617 LLIGAIN---IENGKANSVR--NAVTQEFGP----VP--------DTARYYKKHGIRWVVIGDEN 664

  Fly   787 YGSGSSRDWAAKGPFLLGIKAVIAESYERIHRSNLVGMGIIPLQFLPGQSADTLKLSGREVYNIV 851
            ||.||||:.||..|..||.:|:|.:|:.|||.:||...|::||.|     ||.      ..||.:
Mouse   665 YGEGSSREHAALEPRHLGGRAIITKSFARIHETNLKKQGLLPLTF-----ADP------SDYNKI 718

  Fly   852 LPEGEL--------KPGQRIQ--VDADGNVFETTLRFDT--EVDITYYKNGGILNYM 896
            .|..:|        .||:.::  :.......||.|...|  |..|.:::.|..||.|
Mouse   719 HPVDKLTIQGLKDFAPGKPLKCVIKHPNGTQETILLNHTFNETQIEWFRAGSALNRM 775

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Irp-1ANP_477371.1 PTZ00092 1..901 CDD:240263 241/902 (27%)
AcnA_IRP 88..579 CDD:153136 140/507 (28%)
AcnA_IRP_Swivel 683..852 CDD:238812 52/168 (31%)
Aco2NP_542364.1 aconitase_mito 45..775 CDD:273561 238/894 (27%)
AcnA_Mitochondrial 95..505 CDD:153134 140/507 (28%)
Substrate binding. /evidence=ECO:0000250 192..194 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 524..560 10/51 (20%)
AcnA_Mitochon_Swivel 587..735 CDD:238810 54/184 (29%)