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Protein Alignment Irp-1A and Aco1

DIOPT Version :9

Sequence 1:	NP_477371.1	Gene:	Irp-1A / 42689	FlyBaseID:	FBgn0024958	Length:	902	Species:	Drosophila melanogaster
Sequence 2:	NP_031412.2	Gene:	Aco1 / 11428	MGIID:	87879	Length:	889	Species:	Mus musculus

Alignment Length:	898	Identity:	612/898 - (68%)
Similarity:	722/898 - (80%)	Gaps:	17/898 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 NPFAQFQESF--TQDGNVYKYFDLPSI-DSKYESLPFSIRVLLESAVRNCDNFHVLEKDVQSILG 68
            ||||...|..  .|.|.  ::|:|..: ||:|..||||||||||:||||||.|.|.:.|:::||.
Mouse     3 NPFAHLAEPLDAAQPGK--RFFNLNKLEDSRYGRLPFSIRVLLEAAVRNCDEFLVKKNDIENILN 65

  Fly    69 WTPSLKQETSDVEVSFKPARVILQDFTGVPAVVDFAAMRDAVRELGGNPEKINPICPADLVIDHS 133
            |.   ..:..::||.|||||||||||||||||||||||||||::||||||||||:||||||||||
Mouse    66 WN---VMQHKNIEVPFKPARVILQDFTGVPAVVDFAAMRDAVKKLGGNPEKINPVCPADLVIDHS 127

  Fly   134 VQVDFVRSSDALTKNESLEFQRNKERFTFLKWGARAFDNMLIVPPGSGIVHQVNLEYLARVVFES 198
            :||||.|.:|:|.||:.|||:||||||.|||||::||.||.|:||||||:|||||||||||||:.
Mouse   128 IQVDFNRRADSLQKNQDLEFERNKERFEFLKWGSQAFCNMRIIPPGSGIIHQVNLEYLARVVFDQ 192

  Fly   199 DSSADGSKILYPDSVVGTDSHTTMINGLGVLGWGVGGIEAEAVMLGQSISMLLPEVIGYRLEGKL 263
            |.      ..||||:||||||||||:|||||||||||||||||||||.|||:||:||||:|.||.
Mouse   193 DG------CYYPDSLVGTDSHTTMIDGLGVLGWGVGGIEAEAVMLGQPISMVLPQVIGYKLMGKP 251

  Fly   264 GPLATSTDLVLTITKHLRQLGVVGKFVEFYGPGVAELSIADRATISNMCPEYGATVGYFPIDENT 328
            .||.||||:||||||||||:|||||||||:|||||:|||||||||:|||||||||..:||:||.:
Mouse   252 HPLVTSTDIVLTITKHLRQVGVVGKFVEFFGPGVAQLSIADRATIANMCPEYGATAAFFPVDEVS 316

  Fly   329 LSYMRQTNRSEKKIDIIRKYLKATRQLRDYSLVDQDPQYTESVTLDLSTVVTSVSGPKRPHDRVS 393
            ::|:.||.|.|.|:..|:|||:|....||::...|||.:|:.|.|||.|||...||||||.|:|:
Mouse   317 IAYLLQTGREEDKVKHIQKYLQAVGMFRDFNDTSQDPDFTQVVELDLKTVVPCCSGPKRPQDKVA 381

  Fly   394 VSSMCEDFKSCLISPVGFKGFAIPPSALAASGEFQWDDGKSYKIGHGSVVIAAITSCTNTSNPSV 458
            ||.|.:||:|||.:..|||||.:.|........|.:.:.: :.:.||||||||||||||||||||
Mouse   382 VSEMKKDFESCLGAKQGFKGFQVAPDRHNDRKTFLYSNSE-FTLAHGSVVIAAITSCTNTSNPSV 445

  Fly   459 MLGAGLLAKNAVQKGLSILPYIKTSLSPGSGVVTYYLRESGVIPYLEQLGFDIVGYGCMTCIGNS 523
            |||||||||.||:.|||:.|||||||||||||||||||||||:|||.|||||:||||||||||||
Mouse   446 MLGAGLLAKKAVEAGLSVKPYIKTSLSPGSGVVTYYLRESGVMPYLSQLGFDVVGYGCMTCIGNS 510

  Fly   524 GPLDENVVNTIEKNGLVCCGVLSGNRNFEGRIHPNTRANYLASPLLVIAYAIAGRVDIDFEIEPL 588
            |||.|.||..|.:..||..||||||||||||:||||||||||||.|||||||||.|.||||.|||
Mouse   511 GPLPEPVVEAITQGDLVAVGVLSGNRNFEGRVHPNTRANYLASPPLVIAYAIAGTVRIDFEKEPL 575

  Fly   589 GVDSNGKEVFLRDIWPTRSEIQEVEHKHVIPAMFQEVYSKIQLGSRDWQTLEVSDSKLYPWSEIS 653
            ||::.|::|||:||||||.|||.||.:||||.||:|||.||:..::.|..|.....|||.|:..|
Mouse   576 GVNAQGRQVFLKDIWPTRDEIQAVERQHVIPGMFKEVYQKIETVNKSWNALAAPSEKLYAWNPKS 640

  Fly   654 TYIKLPPFFEGMTRALPKLKGIEKARCLLLLGDSVTTDHISPAGSIARKSPAARYLSERGLTPRD 718
            ||||.|||||.:|..|...|.|..|..||.||||||||||||||:|||.|||||||:.||||||:
Mouse   641 TYIKSPPFFESLTLDLQPPKSIVDAYVLLNLGDSVTTDHISPAGNIARNSPAARYLTNRGLTPRE 705

  Fly   719 FNSYGSRRGNDAVMARGTFANIRLVNKLASKTGPSTLHVPSGEEMDIFDAAERYASEGTPLVLVV 783
            ||||||||||||:|||||||||||:||..:|..|.|:|:||||.:|:|||||||...|.||:::.
Mouse   706 FNSYGSRRGNDAIMARGTFANIRLLNKFLNKQAPQTVHLPSGETLDVFDAAERYQQAGLPLIVLA 770

  Fly   784 GKDYGSGSSRDWAAKGPFLLGIKAVIAESYERIHRSNLVGMGIIPLQFLPGQSADTLKLSGREVY 848
            ||:||||||||||||||||||||||:||||||||||||||||:|||::|||::||:|.|:|||.|
Mouse   771 GKEYGSGSSRDWAAKGPFLLGIKAVLAESYERIHRSNLVGMGVIPLEYLPGETADSLGLTGRERY 835

  Fly   849 NIVLPEGELKPGQRIQVDAD-GNVFETTLRFDTEVDITYYKNGGILNYMIRKM 900
            .|.:|| :|||...:|:..| |..|:..:||||:|::||:.||||||||||||
Mouse   836 TINIPE-DLKPRMTVQIKLDTGKTFQAVMRFDTDVELTYFHNGGILNYMIRKM 887

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.