DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wge and LOC797750

DIOPT Version :9

Sequence 1:	NP_732790.3	Gene:	wge / 42687	FlyBaseID:	FBgn0051151	Length:	1669	Species:	Drosophila melanogaster
Sequence 2:	XP_009298101.1	Gene:	LOC797750 / 797750	-ID:	-	Length:	2774	Species:	Danio rerio

Alignment Length:	2250	Identity:	466/2250 - (20%)
Similarity:	698/2250 - (31%)	Gaps:	957/2250 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 PTTAAVSHPGAHTAHLQLDQFG-----------GFSAATATPLQHHHH---QQTNSSYTFVQIKR 78
            |..|:.|||.:....:.....|           |......|.::|..|   ::...:|  ::..:
Zfish   854 PCQASGSHPSSRQGRVHSTMKGTPRSMYSSDLPGEEERKRTSIEHMGHRCIERERDAY--IRDNK 916

  Fly    79 EPCQVSEI-SSNNCHQQQQQH-------------------HQH--HQHQVQHQGLSSASMTASSK 121
            |..:.:.| .||:||.....|                   |.|  |.|.:...|..|..||..|.
Zfish   917 ERVEFAHIHPSNSCHGDLTSHIMVPGGTSMQSGQLGDPASHSHSAHHHWMPRTGSPSLWMTGHSY 981

  Fly   122 TMSSSTLTTLVKIEAPSPKVSELEKSTGNSVPIGIAVARKRPQEALVPAINTPATLPLQP--PLN 184
            .:..:.|                    ..::|.|.:.|        :||       ||||  ||.
Zfish   982 GIGHTAL--------------------HQNLPPGFSAA--------MPA-------PLQPVLPLP 1011

  Fly   185 KDLNCFGIRVADLGATSCGNLYFTGNGDLMTTGTATAEELALSAAGVNRAPSTFWQYPNALPIES 249
            :|                                                |||
Zfish  1012 QD------------------------------------------------PST------------ 1016

  Fly   250 VISMSPATVGLQYSREASRGQVVLLPAGPTALGISNFPLLTPTDPFQQAAAAAAFVWPSAYIPQA 314
                                |:|:||:.|     :..| .|..|..:|..     :||..|
Zfish  1017 --------------------QLVVLPSEP-----ATHP-STHLDVMEQPG-----LWPPVY---- 1046

  Fly   315 PAPGGHSAAAAAAAASLQPTPNLSSLPNFIFPSMGGHQALSTTPSYASTLQLYLAAAATATGSST 379
            .|.|.||        .:|                  |.::.....:....:||      |.....
Zfish  1047 RARGAHS--------HMQ------------------HPSVYPRSQFLRQQELY------ALQQHQ 1079

  Fly   380 MCQHSNQQTSTTTTNSTINLSLAAGSGVTQSGNAASSLSSSSSLSASSSRFLSLATGQTGIPSLL 444
            ..||....:..|....|   ..||.:...|..:.|....|...:...|
Zfish  1080 QLQHQQHPSHHTPPPQT---HRAANNTELQQRDTADHSQSIFKVQKKS----------------- 1124

  Fly   445 SLPPPTGLKEEYPMPLALPPLVPLEAARDKEQALNLMRLPTPPTSATMEPSSLGHATPHHLFQSG 509
                     ||..|.|              |..|:..|.|.||......|||...:...     |
Zfish  1125 ---------EEQSMEL--------------EDILSDPRTPKPPKCYGYGPSSRVSSPAR-----G 1161

  Fly   510 AMATPTPALLNLSMHGNGGELPAATPLPAVSDEAALNYKLHAPLTPQTPP----RLADIPVSGST 570
            :.|..:|...:..|..:....| :||.||.|..|.      .|.:|...|    ||..:
Zfish  1162 STAHLSPCCQSPCMRPHPKSTP-STPCPAPSPVAV------TPCSPAISPSPSQRLKSV------ 1213

  Fly   571 QLLPQMQDVNIQTDTPVCSEDESFPGSAKPQDPAAEAFP---------PPTHVQPLELTKP---- 622
                :.|:..::...|     :.:|.|.:|..|....:|         |.|  |.::||:|
Zfish  1214 ----ESQEKRVEGQPP-----QDYPQSMEPDLPPGYTYPEINMGYRNGPMT--QDVQLTEPADLE 1267

  Fly   623 ---SEA-SHTQPT--------ECHTQTEPSDIPSAS-------------------QEESAEQTPP 656
               ||| .||.||        ||||...|...|.|.                   |.|..|....
Zfish  1268 PVQSEAVEHTSPTLSSLGEGLECHTMVRPLQEPQAPTMEVDATSLVEEQHEGVFVQGEDVETVMA 1332

  Fly   657 ----EPIETMTQATQADQTS-PEDLTGLELLSNISTNSKPLVRVKQEPVEHIEQPAPQPQPVNIM 716
                ||:|...:...|:... |:::...|:..:.:.:|:.::. ::||:...|:...:.     :
Zfish  1333 MGCCEPVEANQEKEHAEIICVPDEVQDCEVGQSPTLSSEEVIH-EEEPIASFEEKVEKD-----I 1391

  Fly   717 PSEPTLPMPPMLEMEPTSEREPLGGLKLLCA-------LAEQRIQEEVVQGSS-LFATPS----- 768
            |.:.|..:..:.::||...::|       ||       ..|..:..|..|||: ....||
Zfish  1392 PPQETEGIETLKDLEPPLTQKP-------CASDCSPTTQEEDAVIGEEDQGSNCTTVAPSTSNTC 1449

  Fly   769 --SRTPTPTSLALGTTAA----TPPIFEAKSCYAFGQSQGSVFPSSTSSFQM-----PLSSPGFP 822
              |.|.:..||.|...||    .||                  ||..||:|.     ||:|
Zfish  1450 SQSLTSSYWSLELLIAAAFCGDCPP------------------PSPPSSYQSQKSCGPLNS---- 1492

  Fly   823 SMQGIELPTTSAGIVAELTPVKRKKHKHSKSSGSD-----------------------SRKSARC 864
            :..|:||       ::||..::.:::..|.|...:                       |::|...
Zfish  1493 TYHGMEL-------LSELADLELQRYHQSCSKTQEEDQWIFDLQSLATLAAARALELGSQESVTT 1550

  Fly   865 SKKSKKKRHHSSSRQQFS-APAEEDLDLQDDQLQSELRNALHAVDPSYAQRFGQEVFSIMDNSMR 928
            .:|....|...:.|::.| .|..|.:        ..::..:.::|       |||:      .||
Zfish  1551 DEKQYPARRTLNLRRKCSWTPRHEPV--------CPVKGTMDSMD-------GQEL------EMR 1594

  Fly   929 MRLAKITRQYRKKKRKLDEIS-KH----------------------------------------- 951
            :|||::.::|::|:::|.::. ||
Zfish  1595 VRLAELQQRYKEKQKELAKLQRKHDHQKEETPRSPARRGPGRPRKRKSVPGLGSGALTEPQKKVK 1659

  Fly   952 -----------------KKKKKCSK-----------------------QQL-ELQQ--------- 966
                             ||:||.|.                       ||: :|:|
Zfish  1660 LVGAGLSPLAEERGDSQKKRKKLSNRGFSRLSSAQMKSQCYRKNSTIDQQITQLKQRVPGGQHTS 1724

  Fly   967 ----------------------------QQASQQAVQPSSALQQPQMTLSSVLG----------- 992
                                        :..|..|....|..|:......||.|
Zfish  1725 GTTASKSLYSGHSGSKRDSAQLSTANESESLSDTATSGDSGTQESWKRHESVAGKRERKKSPGAT 1789

  Fly   993 -----------------------TSSP----------------------------LRDYKF---- 1002
                                   ||.|                            .||..|
Zfish  1790 ACLQQPGARIPQGRRQEVDEDGETSPPESESSEQEEEEEEGSYGSEEGQDVKAPAFRDLSFSPAV 1854

  Fly  1003 ---PKFSSSNLQA---------------SSF-------LRFPDKT--HSFP----PPPSLQQSQP 1036
               ..||...|:|               |.|       ::...:|  .|.|    .|||.::...
Zfish  1855 TGPSPFSVVKLEANQKAKIKRERQELYGSQFHAVTEGDVKVKQRTPCRSVPITVSKPPSARRRPG 1919

  Fly  1037 EPN-----------------------PLPSSSSPSTSSFVRLEPSALDAAVAIAPTTSSTSTSG- 1077
            .|.                       |.|||||.      ||:.:....::..|...|..||..
Zfish  1920 RPRLQDKHWSGMGGRPCHYRKSSNLLPFPSSSSE------RLKRATRKTSMLRATRRSYWSTKAQ 1978

  Fly  1078 SPSTKQVASARKQ--RKMKASTVGAAGEQTAATEA-----KRRFSAIDRELQLT----------- 1124
            ||.:....|.|:.  |:.|...|....|..||.|.     ...||..|.|.:::
Zfish  1979 SPDSDDNGSTRRTRLRESKGRAVSRLMESFAADEGFHLGEDSSFSEEDEERKVSASCRIAPAPPN 2043

  Fly  1125 ---SEHLYRDETRVL-TDMGGLFYAGVMKPLRPPDVYSITLDGERGNKSHVMSREDILKDTILEV 1185
               ::.|..|..::| :....|.||..::||..||||||.:||||||:..|.|.|.:|::.:|:|
Zfish  2044 CVLTKELLTDGLKILISKEDELLYAARVQPLESPDVYSIVIDGERGNRPRVYSLEQLLQEAVLDV 2108

  Fly  1186 APKSVESVPVGTRLCAYWSQQYRCLYPG---RAIDSEQVVDGTASSATNAATTAPDFVSVEFDDG 1247
            .|.:...:..|||:|||||::.||||||   |..|..:                |..|.||||||
Zfish  2109 RPDTETVLTEGTRVCAYWSERSRCLYPGYVRRGGDESK----------------PGGVMVEFDDG 2157

  Fly  1248 DSGRIRLQNIRMLLSDYPIA------------------------------------EYNDNPLYS 1276
            |.|.|.|.|||.|...|.|.                                    :..:..:..
Zfish  2158 DRGWISLSNIRFLPPGYQIQCTESSTALIPEVHPSKNSSEQESRTVSEKMARADRFKSQEKTVRR 2222

  Fly  1277 VGKQKRSALRG------GESGPGGVTQDHLTVPGCE----------------------------- 1306
            .|:.|.|.|:.      .:|....:|...:..|...
Zfish  2223 PGRPKGSGLKKSLSDTVAKSSASALTWPSVAAPRKRMPVNFFQLNGSTSKKTLKSRVVEISSRPT 2287

  Fly  1307 ------------------DSHSHHSLGMSSDNTTSLAATME-LFTQRSEKKRLKKS--------- 1343
                              ||.|..:.|.||..:.:...::| ..|..|:||:.::|
Zfish  2288 VSMTTPTKGLFSSSSFEVDSFSSIANGYSSFGSQTSGISLEGKNTSYSQKKKAEESAPPRGRKVE 2352

  Fly  1344 -LKKMSKAQNGV-SPATATN-----------GGADAAAL------------------GDGVSAED 1377
             |.|:.  ..|| ||.|..:           |.:...:|                  |||..||.
Zfish  2353 FLVKLD--HEGVTSPKTKNSKALLLLGASGFGSSGVGSLPRAEVYSHPVLLVKDNRKGDGSRAEL 2415

  Fly  1378 AARKHHKHKKRKK--------------HKKHHRKNGSEEQEQQVVQQDYSA----------AGQ- 1417
            ..::....||...              |:.........::|:..::.|.:|          |||
Zfish  2416 LLKRTSIQKKASPSLHLNEYGDLNLGCHRDCQSSYSDMDEEEVEIRTDSNALASASGGLRTAGQF 2480

  Fly  1418 -------EATEAPSTEMSSATSSRVKVEVKVKTEQLEMEEEESASNLMSEIS------------- 1462
                   .::...|:..||.:.|...:...........|:|||::.|:....
Zfish  2481 LSRISVSSSSSGSSSSSSSGSLSSSSLCSSDNDSSYSSEDEESSTLLLQSCMTPHHSMLQTTEAP 2545

  Fly  1463 ---------------DEAKGDDLVEHNNSKGSS-------------------------------K 1481
                           ..|||.   :.|::.||.                               :
Zfish  2546 VGPSRHTFVAKAVAVSSAKGG---QSNHNTGSKQLKRKECASSLSKSSKDLVKRQRLLADQTKPR 2607

  Fly  1482 IAAFLPERQLWGWYGTAYRKAGVKGRARKQFYKTIKRGKETITVGDSAVFLSTGRPDRPYIGRIE 1546
            ::..||.||||.|.|...::.|:||:|||.|||.|.|||:.:.|||.|||||||.|..|.|||||
Zfish  2608 VSPILPPRQLWRWSGNPTQRRGLKGKARKLFYKAIVRGKDIVRVGDCAVFLSTGHPPLPLIGRIE 2672

  Fly  1547 SMWETTTGNKVVRVAWFYHPEET-TGCPKLKFPGALFESPHEDENDVQTISHRCEVLQFGSYFEK 1610
            |.||:...:.||:|.|||||||| .|........||::|.||||||||||||:|:|:.    .|:
Zfish  2673 SFWESWQNSMVVKVKWFYHPEETKLGKRHRDGKHALYQSCHEDENDVQTISHKCQVVT----CEE 2733

  Fly  1611 FGADSKQYQSIYDNNDTYYLAGHYNPRLQVLKLQDDIPTL 1650
            :...::..:|....:|.|||||.|:|....|...|.:..|
Zfish  2734 YDRLTRNRKSDGSYHDLYYLAGTYDPTSGQLLTADGMSIL 2773

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wge	NP_732790.3	BAH_BAHCC1	1520..1642	CDD:240065	60/122 (49%)
LOC797750	XP_009298101.1	BAH_BAHCC1	2646..2766	CDD:240065	61/123 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583625
Domainoid	1	1.000	118	1.000	Domainoid score	I5815
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm25712
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12505
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2140
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.940