DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wge and bahcc1b

DIOPT Version :9

Sequence 1:	NP_732790.3	Gene:	wge / 42687	FlyBaseID:	FBgn0051151	Length:	1669	Species:	Drosophila melanogaster
Sequence 2:	XP_009305095.1	Gene:	bahcc1b / 794333	ZFINID:	ZDB-GENE-100716-2	Length:	2688	Species:	Danio rerio

Alignment Length:	2725	Identity:	531/2725 - (19%)
Similarity:	794/2725 - (29%)	Gaps:	1199/2725 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 PGASSSAADVLSATTATATFLVPTTAA-VSHP--------------GAH-TAHLQL--------- 45
            |..|.|.....|:.:...|||..:..: .|||              |.| ||..|:
Zfish    54 PPHSGSGLIGNSSASFMGTFLASSLGSPPSHPSGPPSSPSSPPYRSGPHSTAPSQIWFPHSHEAP 118

  Fly    46 --DQFGGFSAAT---ATPLQHHHHQQTNSSYTFVQ-----------IKREPCQVSEISSN----- 89
              .:|.|..|.|   .:||.||    .|||..:.|           ::..|.|...:|:|
Zfish   119 GYPRFSGSLAPTFLPMSPLDHH----GNSSVLYGQHRFYDTQKDFYLRSLPSQPHLLSANHSLPP 179

  Fly    90 -----------NCHQQ-------------------------------------QQQH------HQ 100
                       :|.::                                     |.:|      |.
Zfish   180 LSRTAPAHPLDSCSREREPGSTVSQKSSKETGVAERRVGPGGKEKEKSKQESKQDRHHGPPTLHH 244

  Fly   101 HHQHQVQH--QGLSS-----------ASMTASSKTMSSSTLTTLVKIEAPS---PKVSEL---EK 146
            ||||..||  |||..           :|...|:||.:.|......:...||   |..|.|   .:
Zfish   245 HHQHHPQHHPQGLEDDFRHKDDPKHLSSCLLSTKTQNGSDPGAATRGSLPSCVGPGASSLGTGRQ 309

  Fly   147 STGNS--------------------------------------VPIGIAVA------------RK 161
            ::|:|                                      .|:|:..|            ..
Zfish   310 TSGDSHCCKEGVSGEMRISEPASDCLRHSAMLGHAHPMPYSMPPPLGLGSAVGGSWLHPNHPHHH 374

  Fly   162 RPQ----EALVPAINTPATLPL--QPPLNKD-----------LNCFGIRVADLGATSCGNLYFTG 209
            .|.    |...|....|.|:|.  :..|.:|           :...|.:::  |....||.:..|
Zfish   375 HPHHPHAELFCPPPPAPLTMPTAQEKSLGRDSEVTGPTFVPSVGPLGDKIS--GPFQLGNHHCRG 437

  Fly   210 -NGDLMTTG------TATAEELALSAAGVNRAPSTFWQ---------YPNALPIESVISMSP--- 255
             .|.::..|      |.|.|..:..:...|..|....|         |..|       ..||
Zfish   438 VGGGMIAVGGSAGKETKTPERSSSGSRAANLLPQNSCQRKSSQQQHAYGKA-------DKSPDWP 495

  Fly   256 -----ATVGLQYSR---------------EASRGQVVLLPAGPTALGISNFPLLTPTDPFQQAAA 300
                 .|..:|:|:               |.|......||.|......:...:...|.||:..:.
Zfish   496 PGPHLRTNEVQHSQNQHTHSARSCSLDSSEESDAFRPSLPQGTKGGHQAKSSIYASTPPFRDCSH 560

  Fly   301 AAAFVWPSAYIPQAPAPG----------------------GHSAAAAAAAASLQPT--------- 334
            :.    ||   .:|.:.|                      .|.|:.......::|.
Zfish   561 SG----PS---NRASSEGKGATEVECTQKSSQRVARIRHQQHRASTGGQGPEMEPNSTTQDKRKM 618

  Fly   335 --------------------------PNLSSLPNFIFPSMGGHQALS----------TTPSYAST 363
                                      |.....|:..:.|:|.....|          |.|..| |
Zfish   619 DMESASQGYGGNRTGTHPSWEVRGPQPRPDEEPHKAYNSLGAASQTSRVDQGPLPPLTAPQEA-T 682

  Fly   364 LQLYLAAAATATGSSTMCQHSNQQTSTTTTNSTINLSLAAGSGVTQSGNAASSLSSSSSLSASSS 428
            |.   .....:.....:.::|:||....|..|..     .|.|..:.|..|...|..:..|..|.
Zfish   683 LG---PQGPESNAMRNLMKYSSQQPLLFTQKSPF-----GGLGCLKQGAVAGERSERNERSDKSG 739

  Fly   429 RFLS--LATGQTGIPSLLS-------------------------LPPPTGL-----KEEYPMPLA 461
            ...|  |..|:..:|...:                         ..||.|:     ::..| |..
Zfish   740 NGSSCALQEGKQTLPPRRASSSGENERSERVGKDSGEAQGEGEVRQPPVGIAVAVARQREP-PCR 803

  Fly   462 LP---------------------PLVPLEAARDK------EQALNLMRLPTP------------- 486
            ||                     |:.|||...|:      |:.|.|    :|
Zfish   804 LPDGHPTHSHHSRVMPSMKGIGHPMYPLEREMDEERKRVCEEQLGL----SPFDRERELLLRENK 864

  Fly   487 ---------PTSAT-----------------MEPSSLGHATPHHLFQSGAMATPTPA-------- 517
                     |:|:.                 .|||:..|.|.||...    .|.:|:
Zfish   865 DRVEFARIHPSSSCHGDLTSHLIVPGGSQLGTEPSAHAHPTHHHWMP----RTGSPSLWMGHSYG 925

  Fly   518 LLNLSMHGN---GGELPAATP----LPAVSDEAALNYKLHAPLTPQTPPRLADI----------P 565
            |.:.::|.|   |......:|    ||...|.:|....|  |..|...|....:          |
Zfish   926 LSHAALHQNLTPGFSTTMPSPLQPVLPLPQDPSAALVVL--PTEPVAHPATHHLDVMEQQGLWPP 988

  Fly   566 VSGSTQLLPQMQDVNIQTDTPVCSEDESFP-----------------------GSAKPQDPAAEA 607
            |.|:......||...:.:.:....:.|.:.                       ...||:||..:.
Zfish   989 VYGARGPTSHMQHPAVYSRSQFLRQQELYALQQHQHQQHRAAQAMELAHRHSHSQRKPEDPPIDL 1053

  Fly   608 FPPPT------HVQPLEL------------------------TKPSEASHTQPTECHTQTEPSDI 642
            ...|:      |.:|..:                        ..|:..||.:.|.|....|||..
Zfish  1054 VEGPSEPHAPKHTKPFSVGPSPKPPPSSSSPGGCASRLSPCCRSPAPRSHLKSTPCTPCPEPSPA 1118

  Fly   643 --------------------PSASQEESAEQTPPEPIETMTQATQAD----QTSPEDLTG----- 678
                                |:.||::..|..||   :...|:.:.|    .|.|....|
Zfish  1119 VAAPRSPALSPHSTPHHLPKPAESQDKRGEGQPP---QDYPQSLEPDLPPGYTYPAIAMGYKGGP 1180

  Fly   679 ----LELLSNISTNSKPLVRVKQEPVEHIEQPAPQPQPVNIMPSEPTL------PMPPMLEMEPT 733
                ::|..:....::     :.||.|    |||:|.|::....||..      |:....|:|..
Zfish  1181 SPQEVQLAEHADLEAE-----QAEPAE----PAPRPHPLSPKGEEPVCHTGVGSPIRISKEIEDV 1236

  Fly   734 SEREPLGGLKLLCALAEQRIQEE-VVQGSSLFATPSSRTPTPTSLALGTTAATPPIFEAKSCYAF 797
            .|.   ||:          |:|: .|....:.||.|..:..|||    .|:...|..:..:....
Zfish  1237 EEE---GGV----------IEEDGQVDEGQVDATLSQTSLCPTS----DTSVAEPFSDKATAIPN 1284

  Fly   798 GQSQGSVFPSSTS-------SFQMPLSSP--GFPSMQGIE---------------LPTTSAGIVA 838
            .|:.|.|.|:...       ..|:|:.:|  ...::|.:|               .||.|:  ..
Zfish  1285 SQTCGIVSPAPAEENNERDMDLQVPMIAPLTTTQNLQSVEPTKHDLDRTVEDGCTPPTNSS--TP 1347

  Fly   839 ELTPVKRKKHKHSKSSGSDSRK------SARCSKKSKKK-----------------------RHH 874
            .|:|........::..||....      :|.|:.:..:.                       ...
Zfish  1348 PLSPCPVPSDLGNQYPGSCIWSLELLIAAALCATRDARMAMSVPVSGNAVAPNYGIELLSELAEL 1412

  Fly   875 SSSRQQFSAPAEEDLDLQDDQLQS----------------------ELRNALH---------AVD 908
            ..|:||.:...|.|.|:....|||                      .||..|:         ..:
Zfish  1413 EQSQQQRNNTGENDDDMLTFDLQSLATLAAARALELAPPIPADSTPPLRRILNLRKKCKWTPRSE 1477

  Fly   909 PSYAQRFGQEVFSIMDNSMRMRLAKITRQYRKKKRKLDEIS-KH-------------------KK 953
            |....:...|.....:.:||:|||::.|:|::|:|:|.::. ||                   :|
Zfish  1478 PVCPVKATMETLDQEELAMRVRLAELQRRYKEKQRELAKLQRKHDHQKEETARSPARRGPGRPRK 1542

  Fly   954 KKKCSKQQLELQQQQASQQAVQPSSALQQP-QMTLSSVLG-------------------TSSPLR 998
            :|..|...:...    :.:.|:.:.|...| .||...:.|                   ||:.::
Zfish  1543 RKSTSAPPIPTD----APKKVKSAGAGAGPGLMTAEDLAGGGDRKRKKKRMTGGPYHHLTSTQMK 1603

  Fly   999 DY------------KFPKFSSSNLQASS-----------FLRFPDKTHSFPPP------------ 1028
            .:            ||.:.:.|.|:..:           ......||.|..|.
Zfish  1604 AHCRPRGRPRLLSTKFKQKACSQLKQKAKAKRGSRLVNLLCHRESKTQSTVPEHQSAKEEHAHNN 1668

  Fly  1029 ------------PSLQQSQP----------------EPNPLPS-------SSSPSTSSFVRLEPS 1058
                        .::||...                ...|||:       :::.:.|.....|..
Zfish  1669 KTGEQGDTAGSGTAVQQDSDGKRSVMKRGARSKAILSSTPLPTRTQQLLCNTAMTDSKLEATEKG 1733

  Fly  1059 ALD-------------AAVAIAPTTSSTSTSGS--PSTKQVASARKQRKMKAST----VGAAGEQ 1104
            ..|             .|..|...:|....||:  ||...:......:|.|..|    .|:....
Zfish  1734 ISDTEEEDDGIYDSEEGAEGIKNLSSKEQLSGAGRPSQCSIVKLEANQKAKNKTERQGFGSMNVS 1798

  Fly  1105 TAATEAKRR--------------FSAIDRELQLTS--------EHLYRDETRVLTD--------- 1138
            ....|.|||              .|.:|.:.:||.        |:.: |.||||..
Zfish  1799 VTKEEMKRRKAPCRPAQVCADHNHSELDEDRRLTGPKWREGSRENTF-DHTRVLKTSPTPRERTT 1862

  Fly  1139 ----------------------------------------------------------------- 1138

Zfish  1863 RKSAVLLGKRKSCWLQALSSQYDDISWSRRIRNKQQAKGRAVSRLLESFAADEGFQIDDDSSFSE 1927

  Fly  1139 --------------MGG----------------------------LFYAGVMKPLRPPDVYSITL 1161
                          ||.                            |.||..:..|..||:||:.:
Zfish  1928 GEEEEEEEEEEPELMGSALPALPNCILTKEILRDGLKVLISKEDELLYAAYVHTLDLPDIYSVVV 1992

  Fly  1162 DGERGNKSHVMSREDILKDTILEVAPKSVESVPVGTRLCAYWSQQYRCLYPG---RAIDSEQVVD 1223
            :|||||:..:.|.|.:|::.:|:|.|::||::..|||:|||||::.||||||   |....|:..:
Zfish  1993 EGERGNRPRIYSLEQLLQEAVLDVQPETVETLMAGTRVCAYWSERSRCLYPGYVRRGGPGEEQKE 2057

  Fly  1224 GTASSATNAATTAPDFVSVEFDDGDSGRIRLQNIRMLLSDYPI--AEYNDNPLYSVGKQKRSALR 1286
            |:              |.|||||||.|.|.|.:||.|...|.:  ||.:...|.|...::|..
Zfish  2058 GS--------------VMVEFDDGDRGWISLSSIRCLPPGYQVHCAEPSPAHLISPSCRRRKT-- 2106

  Fly  1287 GGESGPGGVTQDHLT----------------------VPGCEDSHSHHSLGMSSDNTTSLAA--- 1326
                    .||:.:|                      .||...|.:..|...:|:|.|..|:
Zfish  2107 --------STQEKITQQADASNERSSNTEPRKSAVKAKPGRPKSVNASSKSGASENVTETASPLL 2163

  Fly  1327 ------------TMELFTQRS-EKKRLKKSLKKM-------------------------SKAQNG 1353
                        :|:||.... .||.||.....|                         |...||
Zfish  2164 SWPVATMSRRKPSMDLFQFNGLTKKALKGKESDMFPLLSSTMTTPAKGIFSTSFEVDSFSSIANG 2228

  Fly  1354 -------------------------------------------VSPATATNG------------- 1362
                                                       .||.| .||
Zfish  2229 CTSFGNQQLAPGLPPSHKVVPGSRCRKIGDRKEFLVKLDHEGVTSPKT-KNGKALLLLGNPELQR 2292

  Fly  1363 ------GADAAALGDGVS----------AEDAARKH-HKHKKRKKHKKHHRKNG----------- 1399
                  |..|..:|:..|          .:||.|.. |..|.....:||.:..|
Zfish  2293 SGRMEKGFGAKGIGELTSTMGYSQSVLLVKDAKRNSCHLLKGSSDMRKHPQGLGLSEYTDYGPNC 2357

  Fly  1400 --------SEEQEQQVVQQDYSAAGQEAT---------EAPSTEMSSATSSRVKVEVKV---KTE 1444
                    |:..|.:..::|...|....|         .:.|:..|||:||.......|   ..:
Zfish  2358 HSDCLSSYSDMDEDEDEEEDARRAAMRTTGRFLSRLSVSSSSSGSSSASSSGSLSSSSVCSSDND 2422

  Fly  1445 QLEMEEEESASNLMSE---------------------------------ISDE------------ 1464
            .....:||.||.|:.:                                 ||:.
Zfish  2423 SSYSSDEEEASRLLLQGCLSSHHTLLQQQQHSDPPTAPPRHTFGAKTMSISNSKAAVNSSTGKPP 2487

  Fly  1465 -----AKGDDLVEHNNSK------------GSSKIAAFLPERQLWGWYGTAYRKAGVKGRARKQF 1512
                 |....:|:..:||            |....:||:|.||||.|.|...::.|:||:|||.|
Zfish  2488 KRKEIANSSSVVQSKSSKDFPKKQKMQSSEGPPNSSAFMPGRQLWRWSGNPTQRRGLKGKARKLF 2552

  Fly  1513 YKTIKRGKETITVGDSAVFLSTGRPDRPYIGRIESMWETTTGNKVVRVAWFYHPEET-TGCPKLK 1576
            ||.|.|||:|:.|||.|||||.|||..|:||||||:||:.:.|.||:|.|||||||| .|.....
Zfish  2553 YKAIVRGKDTVRVGDCAVFLSAGRPHLPFIGRIESLWESWSSNMVVKVKWFYHPEETKLGKRHRD 2617

  Fly  1577 FPGALFESPHEDENDVQTISHRCEVLQFGSYFEKFGADSKQYQSIYDNNDTYYLAGHYNP 1636
            ...||::|.||||||||||||:|:|:....| |:.....|...   :..|.|||||.|:|
Zfish  2618 GKHALYQSSHEDENDVQTISHKCQVVSRAEY-ERLSRIRKPNS---NGQDLYYLAGTYDP 2673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wge	NP_732790.3	BAH_BAHCC1	1520..1642	CDD:240065	63/118 (53%)
bahcc1b	XP_009305095.1	BAH_BAHCC1	2560..2680	CDD:240065	63/118 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583624
Domainoid	1	1.000	226	1.000	Domainoid score	I2460
eggNOG	1	0.900	-	-		E1_KOG1886
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	337	1.000	Inparanoid score	I2360
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm25712
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR12505
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2140
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.890