Protein Alignment wge and tnrc18

DIOPT Version :10

• Sequence 1: NP_732790.3
• Gene: wge / 42687
• FlyBaseID: FBgn0051151
• Length: 1669
• Species: Drosophila melanogaster
• Sequence 2: XP_005164235.1
• Gene: tnrc18 / 559514
• ZFINID: ZDB-GENE-100326-1
• Length: 2936
• Species: Danio rerio
• Alignment Length: 2391
• Identity: 517/2391 - (21%)
• Similarity: 759/2391 - (31%)
• Gaps: 993/2391 - (41%)

  Fly     1 MATFNP---GASSSAADVLSATTATATFLVPTTAAVSH-----PGAHTAHLQLDQFG-------- 49
            |.|..|   ||....||             |.:...||     |||.:..|....:|
Zfish   797 MVTGGPTLAGAGRWPAD-------------PASHLASHPWLSRPGAPSMWLSGSPYGLGPPSLHQ 848

  Fly    50 ----GFSAATA----TPLQHHHHQQTNS---------SYTFVQIKREPCQVSEI------SSNNC 91
                |:..|..    .|.|.....||..         .:....::|.|...|.:      |..:.
Zfish   849 ALPPGYPPALTGSIPPPYQFARDPQTGQVVVIPTEHLPHYAEMLERGPPLWSAMYPPAGSSLQHA 913

  Fly    92 HQQQQQHH-----QHHQHQVQHQGLSSASMTASSKTMSSSTLTTLV-KIEAPSP----------K 140
            ||.|...|     ||..:.:|||         :::.|.......|| ::.|..|          :
Zfish   914 HQLQLLSHQQLLRQHELYMIQHQ---------TAQVMELQRNAQLVERLNASQPRTDLDEKLDKR 969

  Fly   141 VSELEKSTGNSVPIGIAVARKRPQEALVPAINTPATLPLQPPLNKDLNCFGIRVADLGATSCGNL 205
            .:|:.||:.:.:|.....:||.|     |...||:|
Zfish   970 AAEVHKSSLSCIPTTTLHSRKPP-----PCSPTPST----------------------------- 1000

  Fly   206 YFTGNGDLMTTGTATAEELALSAAGVNRAPSTFWQYPNALPIESVISMSPATVGLQYSREASRGQ 270
                                                                   .||:..:...
Zfish  1001 -------------------------------------------------------SYSKALTPLP 1010

  Fly   271 VVLLPAGPTALGISNFPLLTPTDPFQQAAAAAAFVWPSAYIPQAPAPGGHSAAAAAAAASLQPTP 335
            |..||:..|||.....|.:..:.|.|          |.:: |.:|||  ||.:.|:|:.|  ||.
Zfish  1011 VPPLPSPVTALKSEERPKVEKSLPQQ----------PYSH-PSSPAP--HSISPASASPS--PTS 1060

  Fly   336 -----------------NLSSLPNFIFPSM-----GGHQALSTTPSYASTLQLYLAAAATATGSS 378
                             :|...|:..|||:     .|:...|.|..:.|.....|..||.|.
Zfish  1061 SIRTKEESVEVSEKEPLSLQKQPSTTFPSIYREIPPGYPYQSITAPFGSHYPYLLQPAAAAD--- 1122

  Fly   379 TMCQHSNQQTSTTTTNSTINLSLAAGSGVTQSGNAASSLSSSSSLSASSSRFLSLATGQTGIPSL 443
                                               |..|:....|.|.:|..|::|.
Zfish  1123 -----------------------------------ADGLAPDVPLPAETSEHLAIAA-------- 1144

  Fly   444 LSLPPPTGLKEEYPMPLALPPLV-PLEAARD---------------------KEQALNLMRLPTP 486
                      :..|..|..|.|| ||:.:|:                     |:.::.|..:.|.
Zfish  1145 ----------DVKPQHLCSPVLVEPLQTSREPEPMEEEGSTVFKKEPNLEDLKDDSIRLAPIITQ 1199

  Fly   487 PTSATMEPSSLGH----ATP--------HH----------LFQSGAM------------------ 511
            .:|...:|.:  |    |||        .|          |:::..:
Zfish  1200 DSSTPTDPEA--HPRTIATPSPEEDPEQEHGEDIKIKRTSLYETSRLDVERSASTETTDASTGLV 1262

  Fly   512 -----------------ATPTPALLNLSMHGNGGELPAATPLPAVSDEAALNYKLHAPLT--PQT 557
                             ..||...|:||...|..:|..|.|..:...|:.|: .|..|.:  |..
Zfish  1263 DYKSSSSYSDTHLVVCDVQPTKQPLDLSDSLNPADLRDAVPDSSTHLESKLD-NLFLPNSGPPHL 1326

  Fly   558 PPRLADI------PVSGSTQL-----LPQMQDVNIQTDTPVCSEDESFPGSAKPQDPAAEAFPPP 611
            ||..|.:      |::|...|     |||...::|.||  .||.....                .
Zfish  1327 PPSSAAVAILPEDPMAGMFALVTASELPQAGAMSILTD--ACSSRSEL----------------C 1373

  Fly   612 THVQPLELTK-PSEASHTQPTECHTQTEPSDIPSA-------SQEESAEQTPPEPIE-------- 660
            |.|.|||.|. ...|..:|..|...|.:|.|...|       |..|:..|...|.||
Zfish  1374 TDVSPLESTALEGMALLSQMAELEMQRQPRDDTQAVIFCGLESLLEAGRQVLLEAIECEPQVIIR 1438

  Fly   661 -----------TMTQATQADQTSPEDLTGL------------ELLSNISTNSKPLVRV------- 695
                       :..|.......|...|.|:            ||........:.||::
Zfish  1439 LPRELNPNKKYSWRQKKDEPMFSKSSLEGMDAAEVDYRVRLAELQQRYKEKQRELVKLQRRRDKE 1503

  Fly   696 --KQEPVEHIEQPAPQPQPVNIMPSEPTLP----------MPPMLEM------------------ 730
              :|:..:||:|   |.:..::....|..|          .||..::
Zfish  1504 EKRQQQQQHIQQ---QERNRSLARRGPGRPRKRKHGLCALSPPSSKLDSRCAKLSRSVLYSEDSE 1565

  Fly   731 ---------------EPTSEREPLGGLKL-----------LC----------ALAEQRIQEE--- 756
                           |...|.:....|||           .|          |:.:.|:.|:
Zfish  1566 SGEVLRKRFRASNRDEEEEEEDGSSALKLKKKKKSWGEQEACSSFSHEVPKMAVKKSRVSEQEQL 1630

  Fly   757 ----------------------VVQGSSLFATPS--SRTPTPTSL-------------ALG---- 780
                                  .:.|||..:.||  ||.|..|.|             .||
Zfish  1631 ASKLDKALSLTKLNKFSKPSCKFIDGSSGKSRPSSGSRVPMLTDLDVRVKMGKSSLSKDLGIFQK 1695

  Fly   781 --------TTAATPPIFEA--------KSCYAFGQSQGSVFPSSTSSFQMPLSSPGFPSMQGI-- 827
                    |.|.|.| .||        |:.|:..:|:.|.:.::|.|.:......|:||...:
Zfish  1696 TSKGGKSKTAAKTKP-SEACLKGKGQRKAPYSPVRSEISSYSNNTDSEEEDSLKDGWPSSSMLGR 1759

  Fly   828 -----ELPTTSAGIVAELTPVKRKKHKHSKSSGSDSRKSARCSKKSKKKRHH--------SSSRQ 879
                 :||    |:.:..:..||...|.:.||.|.|.||.:.:|:.|.|...        |||..
Zfish  1760 TGSHPQLP----GLCSTPSKKKRSSSKRASSSSSSSLKSKQAAKERKHKHFALLLQEAGVSSSED 1820

  Fly   880 QF----------SAPAEEDLDLQDDQLQSELRNALHAVDPS---YAQRFGQEVF--SIMDNSMRM 929
            .|          |...:||.|..|.:|.........:|:.|   ...||.....  .|:.|.:.:
Zfish  1821 SFDQEYSTERDDSEDDDEDEDGYDYELDESDGLCSSSVEESGLGLLARFAASAIPSPIITNPLSL 1885

  Fly   930 RLAKITRQYRKKKRKLDEISKHKKKKKCSKQQL-----ELQQQQASQQAVQ--PS------SALQ 981
                           :...:|.|.|||..:|.|     |....::..:..:  ||      ||.:
Zfish  1886 ---------------VQLEAKQKAKKKEERQSLLGTEFEFTDSESDVKTRKKFPSLLHGKRSAPE 1935

  Fly   982 QPQMTLSSVL-GTSSPLRDYKFPKFSSS------NLQASS--------------FLRFPDKTHSF 1025
            .|.:..:||: ..|||.:..:.||...|      :|.|..              ||.  |...|.
Zfish  1936 LPLLPPASVMRDDSSPTKRGRKPKKPKSPREFSFDLTADGSEDEQWTRRRSERIFLH--DAAQST 1998

  Fly  1026 PPPPSLQQSQP-EPNPL--PSSSSPSTSSFVRL----EPS----ALDAAVAIAP---TTSSTSTS 1076
            |..||.:...| .|.|.  |.:|..|....|:.    :||    ..:..:.:.|   :::.:.||
Zfish  1999 PISPSSKTPLPLTPKPARGPKTSPQSPKELVKAKEVKDPSKKKRIKETPLCLPPPQLSSTPSETS 2063

  Fly  1077 G----SPSTK---QVASAR-----------KQRKMKASTVGAAGEQTAATE-------------- 1109
            |    ||..|   |...||           :|.:.|...|....|..||.|
Zfish  2064 GALPVSPGRKNKVQKPKAREELGQNVLEFPQQARGKGGAVSKLMESMAADEDFEPNQDSSFSEDE 2128

  Fly  1110 -------AKRRFSAIDRELQLTSEHLYRDETRVLTDMGG-LFYAGVMKPLRPPDVYSITLDGERG 1166
                   .:|..:...|...:..:.| :|..|||..|.. |.|||.:..:..||:||:.::||||
Zfish  2129 NPSVSAQPERPCTPAPRNCVINKDEL-QDGLRVLIPMDDKLLYAGHVSTVHSPDIYSVVVEGERG 2192

  Fly  1167 NKSHVMSREDILKDTILEVAPKSVESVPVGTRLCAYWSQQYRCLYPGRAI----DSEQVVDGTAS 1227
            |:.|:...|.:|::.|::|.|.||..:|.|||:.|||||||||||||..:    |.|.|
Zfish  2193 NRPHIYCLEQLLQEAIIDVKPPSVRYLPQGTRIAAYWSQQYRCLYPGTVVRGSPDMEDV------ 2251

  Fly  1228 SATNAATTAPDFVSVEFDDGDSGRIRLQNIRMLLSDYPIAEYNDNPLYSVGKQKRSALRG----- 1287
                     .|.::|||||||:|||.|.:||:|.:||.|.....:|...|...||   ||
Zfish  2252 ---------DDLITVEFDDGDTGRIPLSHIRLLPADYKIQCAEPSPALLVASTKR---RGRKCSK 2304

  Fly  1288 ----GESGPGGVTQD-------------------------------------------------- 1298
                |:..|..:|::
Zfish  2305 DVPDGKETPPKITEESAPKSKGRGRKPKPKPEPEAAPKEHEKPDTPTPTQVPERPLSSQKSSPRP 2369

  Fly  1299 ----------HLTVPGCEDSHSHH--------------------------SLGMSSDNTTSLAAT 1327
                      .:::|...::....                          |:.:.::.:||||:.
Zfish  2370 GRKIKQVGTASVSIPASNENQKKTTGIKPPAKVRSQPQSVYSQPLYGKVLSVDLYNEPSTSLASF 2434

  Fly  1328 ME----------------------------LFTQR-----------------SEKKRLKKSL--- 1344
            :.                            :.|||                 |.|.:..|:|
Zfish  2435 ISNNETSSPTGKGKTVKRLRKPEEEASGFGVKTQRKQPQTEILIKLDHEGVMSPKTKKTKALMMM 2499

  Fly  1345 --KKMSKAQN----GVS----------------PATATNGGADAAALGD----GVSAEDAARKHH 1383
              :.:||.:|    |||                |..|....|::.:...    |.|:|...:..:
Zfish  2500 EGQNLSKRENKSVMGVSYTTISTTEKTIKAKSKPVEAEPPTAESVSTYSVRKLGSSSEGLMKVSN 2564

  Fly  1384 KHKKRKK--------HKKHHRKNGSEE----QEQQVVQQDYSAAGQEATEAPSTEMSSATSSRVK 1436
            ..||.||        .......:|.||    ||::..|...|:....|:...|:..|:::||...
Zfish  2565 SGKKEKKDLECSSSSSSSSSESDGEEEQGATQEKKPKQDSASSISSRASSPTSSSSSTSSSSSGS 2629

  Fly  1437 VEVKVKTEQLEMEEEESASNLMSEISDEAKGDDLVEHNNS--------------------KGSS- 1480
            ......:......:|||:.:...|...:::.....||..|                    |.||
Zfish  2630 HSSSSSSSSSTTSDEESSCSSDEEPVADSQPSPAAEHVASPEEEDVKAKSGSAPNIHKLQKQSST 2694

  Fly  1481 --------------------------------------------------KIAAFLPERQLWGWY 1495
                                                              ||:||||.||||.|:
Zfish  2695 TQQRHQQKTPQRQQKVKQGVGRPKRREGIHLPTTKELAKRQRLPSVENRPKISAFLPARQLWKWF 2759

  Fly  1496 GTAYRKAGVKGRARKQFYKTIKRGKETITVGDSAVFLSTGRPDRPYIGRIESMWETTTGNKVVRV 1560
            |...::.|:||:|:|.|||.|.||||.|.:||.|||||.|||:.|:||.|:||||:...|.||||
Zfish  2760 GKPTQRRGMKGKAKKLFYKAIMRGKEMIRIGDCAVFLSAGRPNLPFIGHIQSMWESWGNNMVVRV 2824

  Fly  1561 AWFYHPEETTGCPKL------------KFPG--------------ALFESPHEDENDVQTISHRC 1599
            .||||||||....||            ..|.              ||::|.|.||||||||||:|
Zfish  2825 KWFYHPEETNPGKKLHDKKNWDQMSGQSLPAVLQASNQRKDFMERALYQSSHIDENDVQTISHKC 2889

  Fly  1600 EVLQFGSYFEKFGADSKQYQSIYDNNDTYYLAGHYNPRLQVLKLQDDIPTL 1650
            .|:....|.:..  .:|:||   |:.|.|||||.|.|...::...|.:|.:
Zfish  2890 LVVSLEQYEQMI--KTKKYQ---DSEDLYYLAGTYEPTTGMIFNTDGVPVI 2935

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wge	NP_732790.3	PHA03247	<484..811	CDD:223021	105/568 (18%)
		Tudor_BAHCC1-like	1189..1265	CDD:410468	38/79 (48%)
		BAH_BAHCC1	1520..1642	CDD:240065	66/147 (45%)
tnrc18	XP_005164235.1	Tudor_TNRC18	2215..2281	CDD:410540	39/80 (49%)
		BAH_BAHCC1	2784..2928	CDD:240065	66/148 (45%)