DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wge and Bahd1

DIOPT Version :9

Sequence 1:	NP_732790.3	Gene:	wge / 42687	FlyBaseID:	FBgn0051151	Length:	1669	Species:	Drosophila melanogaster
Sequence 2:	XP_006234856.1	Gene:	Bahd1 / 362194	RGDID:	1563127	Length:	781	Species:	Rattus norvegicus

Alignment Length:	964	Identity:	188/964 - (19%)
Similarity:	285/964 - (29%)	Gaps:	328/964 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   726 PMLEMEPTSEREPLGGLKLLCALAEQRIQEEVVQGS-----SLFATPSSRTPTPTSLALGTTAAT 785
            |||...||...|||           |.....|.||:     .:..:|...|....:..|...:..
  Rat    19 PMLSSGPTGRGEPL-----------QMEDSNVEQGAEDVEPGMPESPGHLTGRRKNYPLRKRSLV 72

  Fly   786 PPIFEAKSC-YAFGQSQGSVFP-SSTSSFQMPLSSPGFPSMQGIELPTTSAGIVAELTPVKRK-- 846
            |.  :.|:| ....:.:....| |:..:.::|...|..||      ||.|:.....:.|.||:
  Rat    73 PE--KPKACKVLLTRLENVAGPRSADEADELPPDLPKAPS------PTPSSEDAGLVQPRKRRLA 129

  Fly   847 -----------KHKHSKSSGSDSRKSARCSKKSKKKRHHSSSRQQFS--APAEEDLDLQDDQLQS 898
                       ..:...||.:.:|:|.  .....:.|..::....||  .|...||......|..
  Rat   130 SLNAEALNNLLLEREDTSSLAGARRSR--GGDPHRSRDRATGSWSFSKKRPRLGDLGEGSRDLSP 192

  Fly   899 EL---RNALHAVDPSYAQRFGQEVFSIMDNSMRMRL------AKITRQYRKKKRKLDEISKHK-K 953
            ||   ..|....||:..:.......:.:..|....|      |:.....|..:....::.:.| .
  Rat   193 ELAPDEGARRDGDPAPKRLASLNAAAFLKLSQERELPLRPSRAQAEADGRSTEPLAPKVLRPKVN 257

  Fly   954 KKKCSKQQLELQQQQASQQAVQPSSALQQPQMTLSSVLGTSSPLRDYKFPKFSSSNLQASSFLRF 1018
            .|.|.|    ::|...|.:|..|.:..:||:....|......|::    |...:......:.||
  Rat   258 GKNCPK----VRQGAGSGEATGPPNWQEQPEERWPSAPPRGPPIQ----PSHQAPGKALENPLR- 313

  Fly  1019 PDKTHSFPPPPSLQQSQ----PEPNPLPSSSSPSTSSFVRLEPSALDAAVAIAPTTSSTSTSGSP 1079
                   |..|.|...|    |||. .|...||:....:. :||      ..||..:.....|:|
  Rat   314 -------PNLPLLMGGQAALKPEPG-RPGEESPAPKQELH-QPS------FPAPQLAPLPMPGNP 363

  Fly  1080 STKQVASARKQRKMKASTVGAAGEQTAATEAKRRFSAIDRELQLTSEHLYRDETRVLTDMGGLF- 1143
                           |...|..|...                              ||.:||.:
  Rat   364 ---------------ADYSGPCGGPE------------------------------LTALGGFYL 383

  Fly  1144 YAG---------VMKPLRPPDVYSITLDGERGNKSHVMS-REDILKDTILEVAPKSVES-VPVGT 1197
            |.|         ...|:.|           .|..|.|.: .|.:|      :||.||.| ||...
  Rat   384 YCGQDGLQCGSYSPCPMLP-----------EGKLSPVAAPNEGLL------MAPSSVPSGVPFQH 431

  Fly  1198 RLCAYWSQQYRCLYPGRAIDSEQVVDGTASSATNAATTAPDFVSVEFDDGDSGRIRLQNIRMLLS 1262
               ..||....|       .||                         |.|.:|
  Rat   432 ---PPWSASRYC-------SSE-------------------------DTGANG------------ 449

  Fly  1263 DYPIAEYNDNPLYSV-GKQKRSALRGGESGPGGVTQDHLTVPGCED---------------SHSH 1311
                        ||: |....|....|.:..|...:...|..||..               |.:|
  Rat   450 ------------YSICGVLPLSLTHIGTTCGGCPYKMPFTAEGCRSLGQLEFPLPEAGHPASPAH 502

  Fly  1312 HSLGMSSDNTTSLAATM-ELFTQRSEKKRLKKSLKKMSKAQNGVSPATATNGGADAAALGDGVSA 1375
            ..||....:....|..: .|.|..||.:.:.::..:.:|..:|           ..:.|..|.|.
  Rat   503 PLLGCPVPSVPPAAEPIPHLQTPISEPQTVARACPQSAKPPSG-----------SKSGLRTGSSC 556

  Fly  1376 EDAARKHHKHKKRKKHKKHHRKNGSEEQEQQVVQQDYSAAGQEATEAPSTEMSSATSSRVKVEVK 1440
            ....|.  |..:|..|.|..|..                     ...|.......|:..|.|...
  Rat   557 RHTVRS--KAARRPSHPKQPRAQ---------------------RPRPRRRRRRRTNGWVPVGAA 598

  Fly  1441 VKTEQLEMEEEESASNLMSEISDEAKGDDLVEHNNSKGSSKIAAFLPERQLWGWYGTAYRKAGVK 1505
            .:.....::|.|                                            .|.||:
  Rat   599 CEKAVYVLDEPE--------------------------------------------PAIRKS--- 616

  Fly  1506 GRARKQFYKTIKRGKETITVGDSAVFLSTG--RPDRPYIGRIESMWET-TTGNKVVRVAWFYHPE 1567
                   |:.::|..|||.|.|: |.|.:|  :...||:.:|.::||. .:|..::.:.|:|.||
  Rat   617 -------YQAVERHGETIRVRDT-VLLKSGPRKTSTPYVAKISALWENPESGELMMSLLWYYRPE 673

  Fly  1568 ETTG--CPKLKFP--GALFESPHEDENDVQTISHRCEVLQFGSYFEKFGADSKQ 1617
            ...|  .|.:..|  ..:|.|.|:|:|.|..|..:|.||.|..|. :|.|.:|:
  Rat   674 HLQGGRSPSMHEPLQNEVFASRHQDQNSVACIEEKCYVLTFAEYC-RFCAMAKR 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wge	NP_732790.3	BAH_BAHCC1	1520..1642	CDD:240065	36/105 (34%)
Bahd1	XP_006234856.1	Patatin_and_cPLA2	<250..363	CDD:299702	30/136 (22%)
Bahd1	XP_006234856.1	BAH_BAHCC1	624..734	CDD:240065	36/105 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343365
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1886
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740