DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wge and Hers

DIOPT Version :9

Sequence 1:	NP_732790.3	Gene:	wge / 42687	FlyBaseID:	FBgn0051151	Length:	1669	Species:	Drosophila melanogaster
Sequence 2:	NP_001245771.1	Gene:	Hers / 33000	FlyBaseID:	FBgn0052529	Length:	2529	Species:	Drosophila melanogaster

Alignment Length:	1926	Identity:	366/1926 - (19%)
Similarity:	589/1926 - (30%)	Gaps:	634/1926 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ASSSAADVLSATTATATFLVPTTAAVSHPGAHTAHLQLDQFGGFSAATATPLQHHHHQQTNSSYT 72
            ||.:|:.:::||......|....|:           ....|..:......|       .|.|..|
  Fly   838 ASLNASAIVAATYEVERHLDKNLAS-----------DCSSFESYDELDTMP-------TTTSKVT 884

  Fly    73 --------FVQIKREPCQVSEISSNNCHQQQQQHHQHHQHQVQHQ---GLSSASMTASS------ 120
                    .:.||:||.:..|.......:::.:..:...::::..   .:||.|:...|
  Fly   885 SAAAIKTEVIHIKKEPKESKESLRERERERESERRRERDNELKDSTVGKMSSHSIIEESNDSKYS 949

  Fly   121 ----KTMSSSTLTTL-VKIEAPSPK-VSELEKSTGNSVPIGIAVARKRPQEALVPAINTPATLPL 179
                :|.:.:|:||. .:..|.|.| ..:..:.|.:||.|                        :
  Fly   950 KETKETNTDTTITTTGYRDSAASTKDAKDCSRPTSSSVVI------------------------V 990

  Fly   180 QPPLNKDLNCFGIRV-ADLGATS---CGNLYFTGNGDLMTTGTATAEELALSAAGVNRAPSTFWQ 240
            |   :.|:...|:.| |..||..   |...|        ...::..||..|....| ..|.::
  Fly   991 Q---DTDVTITGVYVNASNGAAQEAYCKMQY--------RVQSSVTEERVLRPGSV-EPPKSY-- 1041

  Fly   241 YPNALPIESVISMSP--ATVGLQYSRE--------ASRGQVVLLPAGPTALGISNFPLL------ 289
                .|:.::.||.|  |:.||..:..        |..|..||||....:.|:.:.|.|
  Fly  1042 ----TPLSALSSMLPPGASSGLSEAHSSPPLPVHAAPTGPHVLLPGEHLSAGMYHAPDLGLHTEH 1102

  Fly   290 ------TPTDPFQQAAAAAAFVWPSAYIPQAPAPGG---------HSAAAAAAAA---------- 329
                  .|..| ..||||||....:||.....||||         |..||.||.|
  Fly  1103 ALPDHHGPPPP-SYAAAAAAAAAAAAYHAHQLAPGGGGVLHMHHQHQYAAHAAHAHHYQQAAEYH 1166

  Fly   330 -SLQPTPNLSSLPNFIFPSMGGHQALSTTPSYASTLQLYLAAAATATGSSTMCQHSNQQTSTTTT 393
             ...|.|:     ::..|...||..    |...:.:.:.:|...|.|.....|.
  Fly  1167 GGPPPPPH-----HYGGPPPQGHYG----PPPGAPVPVPVAVPNTVTVPPERCD----------- 1211

  Fly   394 NSTINLSLAAGSGVTQSGNAASSLSSSSSLSASSSRFLSLATGQTGIPSLLSLPPPTGLKEEYPM 458
                     .||                                         |||:.....||.
  Fly  1212 ---------VGS-----------------------------------------PPPSYRASAYPP 1226

  Fly   459 P--LALPPLVPLEAARDKEQALNLMRLPT--PPTSATMEPSSLGH------------ATPHH--- 504
            |  :.:||                   ||  ..:||...||.|.|            ..|||
  Fly  1227 PSSVGMPP-------------------PTLGGGSSAFCAPSPLHHHQHQHQQPGPGVGPPHHDPS 1272

  Fly   505 -LFQ-SGAM-------ATPTPALLN--------LSMHGNGGEL----PAATPLPAVSDEAALNYK 548
             .:| :|.:       |.|.||.:.        :|..|:..:|    .||....|.:|:||...:
  Fly  1273 GYYQPAGPLISPHVIAAPPPPAQVKKLQEEDGPVSAAGSPTQLQQQQAAAEAAAAAADQAAAQSQ 1337

  Fly   549 --------------LHAPLTPQTPPRLADIP---------VSGSTQLLPQMQ-----DVNIQTDT 585
                          .|.|...|.||:....|         .:.:.|.:|..:     .::..|..
  Fly  1338 SQSQGQSHGHAHSHAHNPQQAQHPPQPQPYPAGAVAAAAAAAAAHQGVPYSRSMHAAQMHYSTGY 1402

  Fly   586 PVCSEDESFPGSAKPQDPAAEAFPPPTHVQPLELTKPSEASHTQPTECHTQTEPSD--------- 641
            |        |....|.......:.|||: .|...:|..:.||......|.|..|..
  Fly  1403 P--------PNYYAPYPGEVMCYSPPTY-PPYFSSKVYQPSHPAHPAAHPQGPPPPGAYRRYPYY 1458

  Fly   642 ---IPSASQEESAEQTPPEPIETMTQATQADQTSPEDLTGLELLSNISTNSKP----LV--RVKQ 697
               .|....|...:|.||.|:.:.:.:..|.|..|.........:...|...|    ||  ..:|
  Fly  1459 QHAGPPPPHELYEQQPPPPPVSSGSVSGPAQQQPPTSSPASVGAAGAGTAGAPSGSQLVPAHQQQ 1523

  Fly   698 EPVEHIEQ-PAPQPQPVNIMP--------------SEPTLPMPPMLEMEPTSEREPLGGLKLLCA 747
            ...:|:|. |.|........|              ..|.:..||...                |.
  Fly  1524 HQQQHLEHYPGPPSYYAGYSPGGGASAGQCYTRGLQGPYMEYPPQCP----------------CP 1572

  Fly   748 LAE---QRIQEEVVQGSSLFATPSSRTPTPTSLALGTTAATPPIFEAKSCYAFGQSQGSVFPSST 809
            :.:   :.:......||::.:.....:...:|:.|..|        :.|....|.|..|   ||:
  Fly  1573 MPQSCPKNVHTGPHIGSNIISNIDQSSSCSSSMLLSAT--------SNSNIGGGSSSSS---SSS 1626

  Fly   810 SSFQMPLSSPGFPSMQGIELPTTSAGIVAELTPVKRKKHKHSKSSGSDSRKSARCSKKSKKKRHH 874
            ||..:|..|....:.....| |||.|.|..:||      .:|.|||..|..|.|.|..|....:.
  Fly  1627 SSTTLPACSSATTTTTASAL-TTSRGPVKNVTP------NNSNSSGHTSTNSCRSSNNSNNSSNS 1684

  Fly   875 SS--------------------------------------------SRQQFSA-------PAE-- 886
            |.                                            ::.|:.|       |.|
  Fly  1685 SCQTIEMTSWATAATNTTSTTATTATTGTQCQMLVKTELKGENPQVTKMQYEAHVMPPPTPPESY 1749

  Fly   887 --EDLDLQDDQLQS---ELRNALH-AVDPSYAQRFGQEVFSIMDNSMRM-------RLAKITRQY 938
              .|..|.|||.|.   |||..|. .::.|:.   ||:.....|.:...       :.|.:.|:.
  Fly  1750 CASDEKLLDDQEQEAELELRLRLGLGLEKSHG---GQQHIEAYDLTCSTPPPVTVPQAAAVPRKA 1811

  Fly   939 RKKKRKLDEISKHKKKKKCSKQQLELQQQQASQQAVQPSSALQQPQMTLSSVLGTSSPLRDYKFP 1003
            |..|                  .:..:...|:||.:.|...|:||:...:.:  .:.|    :.|
  Fly  1812 RIGK------------------SMAREMVYAAQQQLLPEKQLKQPKEAAAKL--EAEP----EMP 1852

  Fly  1004 KFSSSNLQASSFLRFPDKTHSFPPPPSLQQSQ-PEPNPLPSSSSPSTSSFVRLEP-SALDAAVAI 1066
            ....:.::|.:.::.   .|......|...|| |:..|.           ::.|| ..|:...|.
  Fly  1853 FVLKAEIKAETKIKI---EHDGEAQASTHISQLPDLKPT-----------IKTEPEQELEQEAAS 1903

  Fly  1067 APTTSSTSTSGSPSTKQVASARKQRKMKASTVGAAGEQTAATEAKRRFSAIDRELQLTSEHLYRD 1131
            .|:.:.|...     .:|...|:|::....    ..:|.....:|:||:.    |.|:|.:   .
  Fly  1904 VPSVAKTEPQ-----PEVEVEREQQEPPVD----EEQQPTPGGSKQRFNL----LALSSGN---K 1952

  Fly  1132 ETRVLTDMGGLFYAGVMKPLRPPDVYSITLDGERGNKSHVMSREDILKDTILEVAPKSVESVPVG 1196
            :|:....     |..::|...|.   |....|.|..:.|..:....:|...:.:..:..:.:.:.
  Fly  1953 KTKTNNS-----YKSLIKQAEPK---SYLCPGRRFIRRHGRAPAKYVKRRQMILTQRQQQRMRLQ 2009

  Fly  1197 TRLCAYWSQQYRCLYPGRAIDSEQVVDG---TASSATNAATTAPDFVSVEFDDGDS--------- 1249
            .|     .||.:......|  :.:||.|   |.|.|.|....|...||:..|...:
  Fly  2010 RR-----EQQQQRRQQREA--AAEVVAGAVVTPSLAGNPIEQAGSEVSIVKDQAPNSSATPSASP 2067

  Fly  1250 --GRIRLQNIRMLLSDYPIAEYNDNPL-----------YSVGKQKRSALRG--GESGPGGVTQDH 1299
              .|.|.|.|..|    .:.|..|..|           :|..||..:|:.|  ..|.|.....||
  Fly  2068 KRARPRKQEIAAL----HLLEGLDTTLSRGYFSDPELNHSSRKQAPTAVGGLYAASSPLTTATDH 2128

  Fly  1300 ---------------LTVPGCEDSHS------------HHSLGMSSDNTTSLAATMELFTQRSEK 1337
                           ...|..|.|.|            ....|.....|...|||
  Fly  2129 RGKQTTAEKRSKSETKKPPSGESSESGLPCKKPRKEPAGKVKGKGKKTTAGAAAT---------- 2183

  Fly  1338 KRLKKSLKKMSKAQNGVSPAT-ATNGG------------------ADAAALGDGVSAEDAARKHH 1383
             .:..:.:..::|.|.::.:. .||..                  .||...|...|...|:
  Fly  2184 -TIASTAETQTEAVNAITASNQETNNNEYQTADLQAQKFRECPAVTDAKVAGTATSTSTAS---- 2243

  Fly  1384 KHKKRKKHKKHHRKNGSEEQEQQVVQQD----YSAAGQEATEAPSTEMSSATSSRVKVEVKVKTE 1444
                ::::::|     |:||.|.:|...    .:.|...||..||.:..:..:.|.:...|....
  Fly  2244 ----QQQNQQH-----SDEQHQFLVPSQPATASATAALAATPPPSRQGQATHTKRTRSRCKFGNR 2299

  Fly  1445 QLEMEEEESASNLMSEISDEA-KGDDLVEHNNSKGSSKIAAFLPERQLWGWYGTAYRKAGVKGR- 1507
            :.:.......|..:......| |.:.:.:.||.               |.|.|.|::.|.....
  Fly  2300 KRQRHRPGGVSYELDVTQPPATKANVVPKWNNG---------------WMWAGKAFQGAVFLNSD 2349

  Fly  1508 ---ARKQFYKTIKRGK-ETITVGDSAVFLSTGRPDRPYIGRIESMWET-TTGNKVVRVAWFYHPE 1567
               ..:..|..::..: :.|.:.|..:..:....:.||:.::..:|:. ..|..::.:.|:|.||
  Fly  2350 DPLVLRTCYPAMRHVEGDIIRIRDCVLLKANEDNELPYVAKVAHLWQNPEDGEMMMSLLWYYRPE 2414

  Fly  1568 ET-TGCPKLKFPGALFESPHEDENDVQTISHRCEVLQFGSY 1607
            .| .|..:...|..::.|.|.|.|.|..:..:|.||.|..|
  Fly  2415 HTDQGRQRNDCPDEVYASRHRDHNSVACVEDKCYVLTFSEY 2455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wge	NP_732790.3	BAH_BAHCC1	1520..1642	CDD:240065	23/91 (25%)
Hers	NP_001245771.1	BAH_BAHCC1	2366..2519	CDD:240065	23/90 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1886
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810