Protein Alignment wge and Tnrc18

DIOPT Version :10

• Sequence 1: NP_732790.3
• Gene: wge / 42687
• FlyBaseID: FBgn0051151
• Length: 1669
• Species: Drosophila melanogaster
• Sequence 2: XP_038945299.1
• Gene: Tnrc18 / 304302
• RGDID: 1307540
• Length: 2952
• Species: Rattus norvegicus
• Alignment Length: 2523
• Identity: 529/2523 - (20%)
• Similarity: 766/2523 - (30%)
• Gaps: 1077/2523 - (42%)

  Fly    27 VPTTAA-------VSHPGAHTAHLQLDQFGGFSAATATPLQHHHHQQTNSSYTFVQIKREPCQVS 84
            :||:|.       ::|||..||       ||..                      |:||:|.:..
  Rat   607 IPTSAGPPRAQARLTHPGVPTA-------GGGR----------------------QLKRDPERPE 642

  Fly    85 EISSNNCHQQQQQHHQHHQHQVQHQGLSSASMTASSKTMSSSTLTTLVKIEAPSPKVSELEKSTG 149
            ...:..    ::......:.:|:|..:..|...|..|...||:..        .|.:.:.|:|..
  Rat   643 SAKTFG----REGSGAQGEAEVRHPPVGIAVAVARQKDSGSSSRL--------GPGLIDQERSLS 695

  Fly   150 -NSVP-------------------IGIAVARKRPQEALVPAINTPATLPLQPPLNKDLNCFGIRV 194
             |:|.                   :|..:  .|.||.|:......|.|
  Rat   696 LNNVKGHGRTEDDCDRARHREDRLLGTRL--DRDQEKLLRESKELADL----------------- 741

  Fly   195 ADLGATSCG------NLYFTGNGDLMTTGTATAEELALSAA--GVNRAPST-FW--QYPNAL-PI 247
            |.|..|||.      ||..||...|..:|..:|:..|..|.  .:.|:.|| .|  .:|..| |.
  Rat   742 ARLHPTSCAPNGLNPNLMVTGGPTLAGSGRWSADPAAHLATHPWLPRSGSTSMWLAGHPYGLGPP 806

  Fly   248 ESVISMSPA-TVGL--------QYSREASRGQVVLLPAGPTALGISNFPLLTPTDPFQQAAAAAA 303
            .....|:|| ..||        |:.|:...||:|::|:.    .:.:|..|       ...|...
  Rat   807 SLHQGMAPAFPPGLGGSLPSAYQFVRDPQSGQLVVIPSD----HLPHFAEL-------MERATVP 860

  Fly   304 FVWPSAYIPQAPAPGGHSAAAAAAAASLQPTPNLSSLPNFIFPSMGGHQALSTTPSYASTLQLYL 368
            .:||:.|      |.|.|....|....|....:.......::......|||....| |..:|..|
  Rat   861 PLWPALY------PPGRSPLHHAQQLQLFSQQHFLRQQELLYLQQQAAQALELQRS-AQLVQERL 918

  Fly   369 AAAATATGSSTMCQHSNQQTSTTTTNSTINLSLAAGSGVTQSGNAASSLSSSSSLSASSSRFLSL 433
            .|.          :|..:.....|..           |:..:|.|..|.:....|...|:   .|
  Rat   919 KAQ----------EHRTEMEEKITKR-----------GLETTGKAGLSATGPGLLPQKSA---GL 959

  Fly   434 ATGQTGIPSLLSLPPP-------TGLKEE---------------YPM---------PLALPPLVP 467
            |||.||.......|||       |.||.:               ||.         |.|.||  |
  Rat   960 ATGPTGTHGKAMSPPPSPRASPVTSLKAKVIQKVEDVSKPPAYTYPATPSSHPSSPPPASPP--P 1022

  Fly   468 LEAARDKEQA---------LNLMRLPTPPTSA---TMEPSSLGHATPHHLFQSGAMATPTPALLN 520
            ......||:|         |.|.:....|..|   .:.|.....|.|.|      ...|.|.||.
  Rat  1023 TPGLTRKEEAPENVVEKKDLELEKEAPSPFQALFTDIPPRYPFQALPPH------YGRPYPFLLQ 1081

  Fly   521 LSMHGNGGELPAATPLPAVSDEAALNYKLHAPLTPQTPP-------------------RLADIPV 566
            .:...:...|....||||...|       ...|:|:..|                   ||||..|
  Rat  1082 PTAAADADGLAPDVPLPADGPE-------RLALSPEDKPICLSPSKIPEPPRDSQEEERLADREV 1139

  Fly   567 --------SGSTQL--------LP-----------------QMQDVNIQTDTPVC---SEDESFP 595
                    .|.|:|        ||                 .::...:.|..|.|   ||...|.
  Rat  1140 KAEIEDIEEGPTELPRLESPLALPVPETMVAVSPAGGCGGSPLEAQALSTAGPGCREPSEVSDFA 1204

  Fly   596 GSAKPQ----------------------DPAAEAFPPPTHVQPLELTKPSEASHTQPTECHTQ-- 636
            ..|:||                      :|..||...|..| ||::......:.|.|.:...|
  Rat  1205 QVAEPQIELPSRTEPHMAALELGTQLTPEPLVEAKEEPVEV-PLDVPMEEPVAETGPEDSLPQPP 1268

  Fly   637 -TEP--------SDIPSASQE---ESAEQTPPEPIETMTQATQADQTSP---EDLTGLELLSNIS 686
             |||        .|:|....:   ..|::..|.|..|..:.|..:...|   :.|.|:..|:..:
  Rat  1269 LTEPPPSLELSDCDLPVPEGQCLNLEAQEAAPAPASTYLEETHPESLLPGLDDPLAGMNALAAAA 1333

  Fly   687 --TNSKPL----------VRVKQEP---VEHI---------------------EQPAPQPQPVNI 715
              ..::||          .::...|   :||.                     |.|.|:|..| :
  Rat  1334 ELPQARPLPSLGTGVPGGEKLDTAPSLVLEHSFLQGITLLSEIAELELDRRGQEVPGPEPNLV-V 1397

  Fly   716 MPSEPTL--------------PMPPMLE----------------MEPTSER--------EPLGGL 742
            .||..:|              |:...|:                |:...||        |.:..|
  Rat  1398 RPSLESLLAASSHMLKEVLESPLSDSLKNLRLPRELNSNKKYSWMQKKEERMFAMKSSLEDMDAL 1462

  Fly   743 KL--LCALAE-----QRIQEEVVQ--------------GSSLF----ATPSSRTPTPTSLALGTT 782
            :|  ...|||     :..|.|:|:              ..||.    ..|..||.||::|
  Rat  1463 ELDFRMRLAEVQRRYKEKQRELVKLQRRRDSGDRHEDAHRSLTRRGPGRPRKRTHTPSAL----- 1522

  Fly   783 AATPPIFEAKSCYAFGQ-SQGSVFPS--------------------------------------- 807
              :||....||....|: |..|:..|
  Rat  1523 --SPPCKRGKSHSGSGKLSSKSLLTSDDYDLGAGIRKRHKGPEEEQEALVSMGKARSRNQSWDDH 1585

  Fly   808 -STSSFQMPL-------------------------------------SSPG-------------- 820
             |:|.|...|                                     .|||
  Rat  1586 ESSSDFMSQLKIKKKKMSSDQEQLASKLDRALSLTKQDKLKSPFKFSDSPGGKWKTSGGCGRFLT 1650

  Fly   821 -FPSMQGIELPTTSAGIVAELTPVKRKKHKH-SKSSGSDSRKSARCSKKSKKKRHHSS-SRQQFS 882
             ..|:.|.:....:.|:...|.|.:..|||. ||:...:....||...||......|. |...::
  Rat  1651 QCDSLLGKDRKALAKGLGLSLKPSREGKHKRASKARKMEGGFKARGQPKSVHSPFASEVSSHSYN 1715

  Fly   883 APAEEDLDLQDDQLQSELRNALHAVDPSYAQRFGQEVFSIMDNSMRMRLAKITRQYRKKKRKL-D 946
            ..::||.||        |:|:..|..||.::.....:..:..||......|:|::.....|.| .
  Rat  1716 TDSDEDEDL--------LKNSWSAQGPSSSKLTSSLLGMVAKNSKPATGPKLTKRGPSGPRTLKP 1772

  Fly   947 EISKHKKKKKC---------------------------SKQQLELQQQQ--------------AS 970
            :.:..:|:..|                           .:::.||::::              |.
  Rat  1773 KEATSRKQSFCLLLREAEAHSSFSDSSAEDSFDQDDSSEEEEEELEEEEEDEEEEGIGSYRLGAG 1837

  Fly   971 QQAVQPS--------------SALQQPQM--TLS-----------------SVLGTSSPLRD--- 999
            :||:.||              |||..|.:  .||                 |::||.....|
  Rat  1838 EQALSPSLEESGLGLLARFAASALPSPVVGPPLSVVQLEAEQKARKKEERQSLMGTEFEYTDSES 1902

  Fly  1000 -YKFPKFSSSNLQASSFLRFPDKTHSFPPPPSLQQSQPEPNPLPSSSSPSTSSFVRL-------- 1055
             .|.||.|.:.|     || |.|....|     .||...|.|...:|.|::....:|
  Rat  1903 EVKVPKQSPAGL-----LR-PKKGAGEP-----GQSLAAPVPGTRASGPTSPDKAKLASEKGRKA 1956

  Fly  1056 -------EPS----------------------ALDAAVAI-APTTSSTST-------SGSPSTKQ 1083
                   ||.                      ..||:.|: ||:.::.:|       .|:||.::
  Rat  1957 RKIRGSKEPGFEAGPEASDDDLWTRRRSERIFLHDASAAVQAPSNAAPATKPSRCGRGGAPSPRK 2021

  Fly  1084 VASARKQRK--------------------------------------MKASTVGAAGEQTAATEA 1110
            .....|.||                                      .|.|...|.|:: |..|.
  Rat  2022 DTGRAKDRKDPRKKKRGKEAGSAATLPSPRVSTLPDSRAPHPGALATAKRSKAKARGKE-AKKEN 2085

  Fly  1111 KRRFSAIDRELQLTS----------------EHLYR-----------------------DETRVL 1136
            :.:..|:.:.::..:                |||.|                       |..|||
  Rat  2086 RGKGGAVSKLMECMAAEEDFEPNQDSSFSEDEHLPRGGATERPLTPAPRSCIIDKEELKDGLRVL 2150

  Fly  1137 TDMGG-LFYAGVMKPLRPPDVYSITLDGERGNKSHVMSREDILKDTILEVAPKSVESVPVGTRLC 1200
            ..|.. |.|||.::.:..||:|.:.::|||||:.|:...|.:|::.|::|.|.|...:|.|||:.
  Rat  2151 IPMDDKLLYAGHVQTVHSPDIYRVVVEGERGNRPHIYCLEQLLQEAIIDVRPASTRFLPQGTRIA 2215

  Fly  1201 AYWSQQYRCLYPGRAI----DSEQVVDGTASSATNAATTAPDFVSVEFDDGDSGRIRLQNIRMLL 1261
            |||||||||||||..:    |.|.  ||             |.::|||||||:|||.|.:||:|.
  Rat  2216 AYWSQQYRCLYPGTVVRGLLDLED--DG-------------DLITVEFDDGDTGRIPLSHIRLLP 2265

  Fly  1262 SDYPIAEYNDNPLYSV--------------GKQKRSALRGGESGPGGVTQDHLTVPGCEDSHSHH 1312
            .||.|.....:|...|              |:.|..|..|.:...||..:.....|..:......
  Rat  2266 PDYKIQCAEPSPALLVPSAKRRSRKTSKDTGEGKEGAATGPQEATGGKARGRGRKPSTKAKADRA 2330

  Fly  1313 SL---GMSSDNTTSLAATMELFTQRSEKKRLKKSLKKMSKAQNGVS------------------- 1355
            .:   |.:::...|....:|..:..:.||...:.:.|.::|....|
  Rat  2331 VVLEEGAATNELPSAPLALEPVSTPNSKKSTPEPVDKRARAPKARSVSVQPSPGPPTFSSCPAPE 2395

  Fly  1356 --------------------PAT--------ATNGGADAAALGDGVSAEDAARKHH------KHK 1386
                                |||        ||.|.........|...|...:..|      |.|
  Rat  2396 PFGELPTPATAPLVTMPVTMPATRPKPKKARATEGSGAKGPRRPGEDDELLVKLDHEGVMSPKSK 2460

  Fly  1387 KRKK------------------------------------------------------------- 1390
            |.|:
  Rat  2461 KAKEALLLREDPGPGAWPESTGLLSLGSYSPTVGSSEPKATWPKGLDGDLTQEPGPGLPLEDPGN 2525

  Fly  1391 ----HKKHHRKNGSEEQEQQVVQQDYSAAGQEATEAPSTEMSSATSSRVKVEVKVKTEQLEMEEE 1451
                .|....::|:||.|........|::...::.:.|:..||::.|..:.|     |..|...|
  Rat  2526 SKSPDKAQAEQDGAEESETTSSSSSSSSSSSSSSSSSSSSSSSSSGSETEGE-----EDAEKNRE 2585

  Fly  1452 E---------------------------------------------------------SASNLMS 1459
            :                                                         |:|:..|
  Rat  2586 DGRGAGGRTCSAASSRASSPASSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2650

  Fly  1460 EISDE---AKGDDLVEHNNSKGSS----------------------------------------- 1480
            ..:||   ...||......:.|.|
  Rat  2651 STTDEDSSCSSDDEAAPAPAAGPSTQPALPTKVSKPPSKARASAHSPGKKAPPTTQPPPQPPPQP 2715

  Fly  1481 ---------------------------------------------KIAAFLPERQLWGWYGTAYR 1500
                                                         |||||||.||||.|:|...:
  Rat  2716 QQTLQPKTQTGAGAKSRPKKREGVHLPTTKELAKRQRLPSVENRPKIAAFLPARQLWKWFGKPTQ 2780

  Fly  1501 KAGVKGRARKQFYKTIKRGKETITVGDSAVFLSTGRPDRPYIGRIESMWETTTGNKVVRVAWFYH 1565
            :.|:||:|||.|||.|.||||.|.:||.|||||.|||:.||||||:||||:...|.||||.||||
  Rat  2781 RRGMKGKARKLFYKAIVRGKEMIRIGDCAVFLSAGRPNLPYIGRIQSMWESWGNNMVVRVKWFYH 2845

  Fly  1566 PEETTGCPKLKFPG---------------------------------ALFESPHEDENDVQTISH 1597
            ||||:       ||                                 ||::|.|.|||||||:||
  Rat  2846 PEETS-------PGKQFHEGQHWDQKSGHNLPAALRASSQRKDFMERALYQSSHVDENDVQTVSH 2903

  Fly  1598 RCEVLQFGSYFEKFGADSKQYQSIYDNNDTYYLAGHYNPRLQVLKLQDDIPTL 1650
            :|.|:....|.:..  .:|:||   |:...|||||.|.|...::...|.:|.|
  Rat  2904 KCLVVGLEQYEQML--KTKKYQ---DSEGLYYLAGTYEPTTGMIFSTDGVPVL 2951

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wge	NP_732790.3	PHA03247	<484..811	CDD:223021	106/563 (19%)
		Tudor_BAHCC1-like	1189..1265	CDD:410468	38/79 (48%)
		BAH_BAHCC1	1520..1642	CDD:240065	65/154 (42%)
Tnrc18	XP_038945299.1	PHA03247	<383..641	CDD:223021	14/62 (23%)
		Tudor_SF	2204..2270	CDD:470623	39/80 (49%)
		PHA03307	2274..>2524	CDD:223039	30/249 (12%)
		BAH_BAHCC1	2800..2944	CDD:240065	65/155 (42%)