DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wge and Tnrc18

DIOPT Version :9

Sequence 1:	NP_732790.3	Gene:	wge / 42687	FlyBaseID:	FBgn0051151	Length:	1669	Species:	Drosophila melanogaster
Sequence 2:	XP_006504750.1	Gene:	Tnrc18 / 231861	MGIID:	3648294	Length:	2951	Species:	Mus musculus

Alignment Length:	2602	Identity:	521/2602 - (20%)
Similarity:	756/2602 - (29%)	Gaps:	1125/2602 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 ASSSAADVLSATTATATFLVPTTA-----------------AVSHPGAHTAHLQLDQFGGFSAAT 55
            ||.:..:...||.:...:|.|..|                 |...||..:|...|.::.|..|..
Mouse   515 ASRAEEEAAVATASKKAYLDPGGAMPRASATCGRPGADLHSAAHGPGEASAMQSLIKYSGSFARE 579

  Fly    56 ATPLQHHHHQQTNSSYTFVQIKREPCQVSEISSNNCHQQQQQHHQHHQHQVQHQGLSSASMTASS 120
            |..::.....:.:.......:|.||...|            ......|.::.|.|:.:|......
Mouse   580 AVAVRPGGCGKKSPFGGLGTMKPEPTPTS------------AGPPRAQARLTHPGVPTAGGGRQL 632

  Fly   121 KTMSSSTLTTLVKIEAPSPKVSELEKSTGNS------------VPIGIAVARKRPQEA-----LV 168
            |.               .|:..|..|:.|..            .|:|||||..|.:::     |.
Mouse   633 KR---------------DPERPESAKAFGREGSGAQGEAEVRHPPVGIAVAVARQKDSGSSSRLG 682

  Fly   169 PAI-NTPATLPL-------------QPPLNKDLNCFGIR--------------VADLG---ATSC 202
            |.: :...||.|             ....:::....|.|              :|||.   .|||
Mouse   683 PGLGDQERTLSLNNVKGHGRTDDECDRARHREDRLLGTRLDRDQEKLLRESKELADLARLHPTSC 747

  Fly   203 G------NLYFTGNGDLMTTGTATAEELALSAAG--VNRAPST-FW--QYPNAL-PIESVISMSP 255
            .      ||..||...|..:|..:|:..|..|..  :.|:.|| .|  .:|..| |......|:|
Mouse   748 APNGLNPNLMVTGGPTLAGSGRWSADPAAHLATNPWLPRSGSTSMWLAGHPYGLGPPSLHQGMAP 812

  Fly   256 A-TVGL--------QYSREASRGQVVLLPAGPTALGISNFPLLTPTDPFQQAAAAAAFVWPSAYI 311
            | ..||        |:.|:...||:|::|:.    .:.:|..|       ...||...:||:.|
Mouse   813 AFPPGLGGSLPSAYQFVRDPQSGQLVVIPSD----HLPHFAEL-------MERAAVPPLWPALY- 865

  Fly   312 PQAPAPGGHSAAAAAAAASLQPTPNLSSLPNFIFPSMGGHQALSTTPSYASTLQLYLAAAATATG 376
                 |.|.|....|....|....:.......::......|||....| |..:|..|.|....|
Mouse   866 -----PPGRSPLHHAQQLQLFSQQHFLRQQELLYLQQQAAQALELQRS-AQLVQERLKAQEHRT- 923

  Fly   377 SSTMCQHSNQQTSTTTTNSTINLSLAAGSGVTQSGNAASSLSSSSSLSASSSRFLSLATGQTGIP 441
              .|.:..::::..||..:.::   |||.|:....:|                  .||.|..|..
Mouse   924 --EMEEKISKRSLETTGKAGLS---AAGPGLLPRKSA------------------GLANGPAGSH 965

  Fly   442 SLLSLPPP-------TGLKEE---------------YPM---------PLALPPLVPLEAARDKE 475
            .....|||       |.||.:               ||.         |.|.||  |......||
Mouse   966 GKAVSPPPSPRASPVTSLKAKVIQKVEDVSKPPAYTYPATPSSHPSSPPPASPP--PTPGLTRKE 1028

  Fly   476 QA---------LNLMRLPTPPTSA---TMEPSSLGHATPHHLFQSGAMATPTPALLNLSMHGNGG 528
            :|         |.|.:....|..|   .:.|.....|.|.|      ...|.|.||..:...:..
Mouse  1029 EAPENVVEKKDLELEKETPSPFQALFTDIPPRYPFQALPPH------YGRPYPFLLQPAAASDAD 1087

  Fly   529 ELPAATPLPAVSDEAALNYKLHAPLTPQTPPRLADIPVSGSTQLLPQMQDVNIQTDTPVCSEDES 593
            .|....||||                 ..|.|||         |.|:        |.|:|.....
Mouse  1088 GLAPDVPLPA-----------------DGPERLA---------LSPE--------DKPICLSPSK 1118

  Fly   594 FPGSAKPQD-PAAEAFPP-------------PTHVQPLE------------LTKPSEASHTQPTE 632
            .|  ..|:| |..|....             ||.:.|||            ...|:......|.|
Mouse  1119 IP--EPPRDSPEEEQLADREVKAEVEDIEEGPTELPPLESPLALPVPETMVAVSPAGGCGGSPLE 1181

  Fly   633 CHTQT-------EPSDIPSASQ-EESAEQTPPEPIETMTQATQADQTSPEDLTGLELLSNISTNS 689
            ....:       |||::...:| .|...:.|.:....||......|.:||
Mouse  1182 AQALSTAGPGCREPSEVSDFAQVAEPQIELPSKTEHRMTALELGTQLTPE--------------- 1231

  Fly   690 KPLVRVKQEPVEHIEQPAPQPQPVNIMPSEPTLPMPPMLEMEPTSE------------------- 735
             |||..|:|||| :....|..:|......|.:||.|.:.|.:|:.|
Mouse  1232 -PLVETKEEPVE-VPLDVPMEEPTTEAGPEDSLPQPSLTEPQPSLELSDCDLPVPEGQCLNLEAQ 1294

  Fly   736 ------------------------REPLGGLKLLCALAE-------------------------- 750
                                    .:||.|:..|.|.||
Mouse  1295 EAVPAPASTCYLEETHSESLLPGLDDPLAGMNALAAAAELPQARPLPSLGPGVPAGEKLDTAPSL 1359

  Fly   751 ----------------------QRIQE--------------------------EVVQG------- 760
                                  :|.||                          ||::.
Mouse  1360 VLEHSFLQGITLLSEIAELELDRRGQEAADPEPNLVVRPSLESLLAASSHMLKEVLESPFSDPLK 1424

  Fly   761 ---------------------SSLFATPSS----------------------------------- 769
                                 ..:||..||
Mouse  1425 NLRLPRELNSNKKYSWMQKKEERMFAMKSSLEDMDALELDFRMRLAEVQRRYKEKQRELVKLQRR 1489

  Fly   770 ----------------RTP-TPTSLALGTTAATPPIFEAKSCYAFGQ-SQGSVFPS--------- 807
                            |.| .|.......:|.:||....||..:.|: |..|:..|
Mouse  1490 RDSGDRHEDAHRSLARRGPGRPRKRTHTLSALSPPCKRGKSHSSSGKLSSKSLLTSDDYDLGAGI 1554

  Fly   808 -------------------------------STSSFQMPL------------------------- 816
                                           |:|.|...|
Mouse  1555 RKRHKGPEEEQEALMGMGKARSRNQSWDDHDSSSDFMSQLKIKKKKMASDQEQLASKLDRALSLT 1619

  Fly   817 ------------SSPG---------------FPSMQGIELPTTSAGIVAELTPVKRKKHKH-SKS 853
                        ..||               :.|:.|.:....:.|:...|.|.:..|||. ||:
Mouse  1620 KQDKLKSPFKFSDGPGGKPKTGGGCGRFLTQYDSLLGKDRKALAKGLGLSLKPSREGKHKRASKA 1684

  Fly   854 SGSDSRKSARCSKKSKKKRHHSS-SRQQFSAPAEEDLDLQDDQLQSELRNALHAVDPSYAQRFGQ 917
            ...:....||...||......|. |.|.::..::||.|.        |:|...|..||.::....
Mouse  1685 RKMEGGFQARGQPKSVHSPFASEVSSQSYNTDSDEDEDF--------LKNEWSAQGPSSSKLTSS 1741

  Fly   918 EVFSIM-DNSMRMRLAKITRQYRKKKRKL-DEISKHKKKKKC----------------------- 957
            .:..:: .||......|:|::.....|.| .::...:|:..|
Mouse  1742 LLCGMVPKNSKPATGPKLTKRGLAGPRTLKPKVVTSRKQSFCLLLREAEARSSFSDSSEEDSFDQ 1806

  Fly   958 ----SKQQLELQQQQ--------------ASQQAVQPS--------------SALQQPQM--TLS 988
                .:::.||::::              |.:||:.||              |||..|.:  .||
Mouse  1807 DDSSEEEEEELEEEEEDEEEEGIGSYRLGAGEQALSPSLEESGLGLLARFAASALPSPVVGPPLS 1871

  Fly   989 -----------------SVLGTSSPLRD----YKFPKFSSSN-LQASSFLRFPDKTHSFPPPPSL 1031
                             |:|||.....|    .|.||.|::. |:....:..|.::.:.|.|.|.
Mouse  1872 VVQLEAEQKARKKEERQSLLGTEFEYTDSESEVKVPKQSAAGLLRTKKGVGEPGQSLAAPGPGSR 1936

  Fly  1032 QQ--SQPEPNPLPS-----------------SSSPSTSS------------FVRLEPSALDAAVA 1065
            ..  |.|:...|.|                 .:.|..|.            |:....:|:.|...
Mouse  1937 ASGPSSPDKAKLVSEKGRKARKIRGPKEPGFEAGPEASDDDLWTRRRSERIFLHDASAAVQATSN 2001

  Fly  1066 IAPTT--SSTSTSGSPSTKQVASARKQRK------------------------------------ 1092
            .||.|  |.....|:||.::.....|.||
Mouse  2002 TAPATKPSRCGRGGAPSPRKDTGRAKDRKDPRKKKRGKEAGSAATLPPPRVSTLPDSRAPHPGAL 2066

  Fly  1093 --MKASTVGAAGEQTAATEAKRRFSAIDRELQLTS----------------EHLYR--------- 1130
              .|.|...|.|:: |..|.:.:..|:.:.::..:                |||.|
Mouse  2067 ATAKRSKAKARGKE-AKKENRGKGGAVSKLMECMAAEEDFEANQDSSFSEDEHLPRGGATERPLT 2130

  Fly  1131 --------------DETRVLTDMGG-LFYAGVMKPLRPPDVYSITLDGERGNKSHVMSREDILKD 1180
                          |..|||..:.. |.|||.::.:..||:|.:.::|||||:.|:...|.:|::
Mouse  2131 PAPRSCIIDKEELKDGLRVLIPLDDKLLYAGHVQTVHSPDIYRVVVEGERGNRPHIYCLEQLLQE 2195

  Fly  1181 TILEVAPKSVESVPVGTRLCAYWSQQYRCLYPGRAI----DSEQVVDGTASSATNAATTAPDFVS 1241
            .|::|.|.|...:|.|||:.|||||||||||||..:    |.|.  ||             |.::
Mouse  2196 AIIDVRPASTRFLPQGTRIAAYWSQQYRCLYPGTVVRGLLDLED--DG-------------DLIT 2245

  Fly  1242 VEFDDGDSGRIRLQNIRMLLSDYPIAEYNDNPLYSV--------------GKQKRSALRGGESGP 1292
            |||||||:|||.|.:||:|..||.|.....:|...|              |:.|..|..|.:...
Mouse  2246 VEFDDGDTGRIPLSHIRLLPPDYKIQCAEPSPALLVPSAKRRSRKTSKDTGEVKEGAATGPQEAT 2310

  Fly  1293 GGVTQDHLTVPGCEDSHSHHSL---GMSSDNTTSLAATMELFTQRSEKKRLKKSLKKMSKAQNGV 1354
            ||..:.....|..:.......:   |.:::...|....:|..:..:.||...:.:.|.::|....
Mouse  2311 GGKARGRGRKPSTKAKADRAVVLEEGAATNEVPSAPLALEPISTPNSKKSTPEPVDKRARAPKAR 2375

  Fly  1355 S--------------------------PAT-----------ATNGGADAAALGDGVSAEDAAR-- 1380
            |                          |||           ||......|...:|..|:...|
Mouse  2376 SISAQPSPVPPTFSSCPAPEPFGELPTPATAPLVTMPVTMPATRPKPKKARAAEGSGAKGPRRPG 2440

  Fly  1381 ---------KHH-----KHKKRKK----------------------------------------- 1390
                     .|.     |.||.|:
Mouse  2441 EDDELLVKLDHEGVMSPKSKKAKEALLLREDPGPGGWPESTGLLSLGSYSPAVGSSEPKATWPKG 2505

  Fly  1391 ------------------------HKKHHRKNGSEEQEQQVVQQDYSAAGQEATEAPSTEMS--- 1428
                                    .|....::|:||.|........|::...::.:.|:..|
Mouse  2506 LDGDLTQEPGPGLPLEDPGNSKNPDKAQAEQDGAEESETTSSSSSSSSSSSSSSSSSSSSSSSSS 2570

  Fly  1429 -------------------------SATSSRVKVEVKVKTEQLEMEEEESASNLMSEISDEAKGD 1468
                                     ||.|||........:.........|:|:..|..|..:...
Mouse  2571 GSETEGEEDAEKNREDGRGAGGRTCSAASSRASSPASSSSSSSSSSSSSSSSSSSSSSSSSSSSS 2635

  Fly  1469 DLVEHNNSKGSS----------------------------------------------------- 1480
            .....::|..||
Mouse  2636 SSSSSSSSSSSSSSSTTDEDSSCSSDEEAAPAPAAGPSTQPALPTKVSKPPSKARSSAHSPGKKA 2700

  Fly  1481 -----------------------------------------------------------KIAAFL 1486
                                                                       ||||||
Mouse  2701 PTTTQPPPQPPPQPQQTLQPKTQAGAGAKSRPKKREGVHLPTTKELAKRQRLPSVENRPKIAAFL 2765

  Fly  1487 PERQLWGWYGTAYRKAGVKGRARKQFYKTIKRGKETITVGDSAVFLSTGRPDRPYIGRIESMWET 1551
            |.||||.|:|...::.|:||:|||.|||.|.||||.|.:||.|||||.|||:.||||||:||||:
Mouse  2766 PARQLWKWFGKPTQRRGMKGKARKLFYKAIVRGKEMIRIGDCAVFLSAGRPNLPYIGRIQSMWES 2830

  Fly  1552 TTGNKVVRVAWFYHPEETTGCPKLKFPG---------------------------------ALFE 1583
            ...|.||||.||||||||:       ||                                 ||::
Mouse  2831 WGNNMVVRVKWFYHPEETS-------PGKQFHEGQHWDQKSGHSLPAALRASSQRKDFMERALYQ 2888

  Fly  1584 SPHEDENDVQTISHRCEVLQFGSYFEKFGADSKQYQSIYDNNDTYYLAGHYNPRLQVLKLQDDIP 1648
            |.|.|||||||:||:|.|:....|.:..  .:|:||   |:...|||||.|.|...::...|.:|
Mouse  2889 SSHVDENDVQTVSHKCLVVGLEQYEQML--KTKKYQ---DSEGLYYLAGTYEPTTGMIFSTDGVP 2948

  Fly  1649 TL 1650
            .|
Mouse  2949 VL 2950

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wge	NP_732790.3	BAH_BAHCC1	1520..1642	CDD:240065	65/154 (42%)
Tnrc18	XP_006504750.1	PHA03247	<1049..1358	CDD:223021	72/367 (20%)
		Tudor_3	2212..2264	CDD:384925	33/66 (50%)
		PRK12323	<2265..2479	CDD:237057	34/213 (16%)
		BAH_BAHCC1	2799..2943	CDD:240065	65/155 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839548
Domainoid	1	1.000	176	1.000	Domainoid score	I3613
eggNOG	1	0.900	-	-		E1_KOG1886
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	226	1.000	Inparanoid score	I3480
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44173
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12505
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4824
SonicParanoid	1	1.000	-	-		X2140
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.880