DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wge and LOC100331694

DIOPT Version :9

Sequence 1:	NP_732790.3	Gene:	wge / 42687	FlyBaseID:	FBgn0051151	Length:	1669	Species:	Drosophila melanogaster
Sequence 2:	XP_005173894.1	Gene:	LOC100331694 / 100331694	-ID:	-	Length:	841	Species:	Danio rerio

Alignment Length:	873	Identity:	172/873 - (19%)
Similarity:	300/873 - (34%)	Gaps:	174/873 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   795 YAFGQSQ----GSVFPS-STSSFQMPLSSPGFPSMQGIELPTTSAGIVAELTPVKRKKHKHSKSS 854
            ||.|.|.    |..:|: |..:.:|..........:...|||.....|.|    :::|....:..
Zfish    20 YAEGWSHDETVGGAWPADSVPNSKMNTHMQSCAQYKSQRLPTPPMNSVNE----RKRKLYPLRGR 80

  Fly   855 GSDSRKSARC----SKKSKKKRHHSSSRQQFSAPAEEDLDLQDDQLQSELRNALHAVDPSYAQRF 915
            |.....|..|    ::..:::...:.:|:...:..:|....:...|.:|..|:|....|:.|.|.
Zfish    81 GGTPEDSLCCHVLLTRLDEQQDSTNKTREPLQSSGQEPRTRRLASLNAEALNSLLLEKPAGAMRT 145

  Fly   916 GQEVFSIMDNSMRMRLAKITRQYRK-----KK--RKLDEISK------HKKKKKCSKQQLELQQQ 967
            ..| .:.|..|.|.......:.:|:     ||  |:.:|..|      .:.:||..::..|.|::
Zfish   146 RAE-GACMKKSWRRPEESQKKSWRRPEESQKKTWRRPEESQKKTWRRPEESQKKTWRRPEESQKK 209

  Fly   968 QASQQAVQPSSALQQPQMTLSSVLGTSSPLRDYKFPKFSSSNLQASSFLRFPDKTH--SFPPPPS 1030
            ...:.........::|:         .|..:.::.|:.|    |..::.| |:::.  |:..|..
Zfish   210 SWKRPEESQKKTWRRPE---------ESQKKTWRRPEES----QKKTWRR-PEESQKKSWRRPEE 260

  Fly  1031 LQQS---QPEPNPLPSSSSPSTS---SFVRLEPSALDAAVAIAPTTSSTSTSGSPSTKQVASARK 1089
            .|:.   :||.:...:...|..|   |:.|.|.|  .......|..|...:...|...|..|.|:
Zfish   261 SQKKTWRRPEESQKKTWRRPEESQKKSWKRPEES--QKKTWRRPEESQKKSWRKPEESQRKSWRR 323

  Fly  1090 ----QRKMKASTVGAAGEQTAATEAKRRFSAIDRE--LQLTSEHLYRDETRVLTDMGGLFYAGVM 1148
                |::||         ....:.|.||.:.::..  |.::|...:......:.:.|
Zfish   324 PEASQKRMK---------MDLCSPAPRRLAGLNTAALLNISSPSAHHRSVCAVGNDG-------- 371

  Fly  1149 KPLRPPDVYSITLDGERGNKSHVMSREDILKDTILEVAP-KSVESVPVGTRLCAYWSQQYRCL-Y 1211
            ||....|..:|..      ::..:.|....:::|..|.. ||:||.|.......|  |.:..| |
Zfish   372 KPTAGNDGKAIAW------RAIKLCRHPSHQESICVVCKGKSLESSPTFQEDPGY--QPHGILGY 428

  Fly  1212 PGRAIDSEQVVDGTASSATNAATTAPDFVSVEFDDGDSGRIRLQNIRMLLSDYPIAEYNDNPLYS 1276
            |.:..|...|......:........|...:|||         ..::.|.|......|..:.|:.|
Zfish   429 PIKTADMRTVSVKEEHAEPVQCCCCPAVGAVEF---------CHHLPMFLHQQAYRESEEQPVAS 484

  Fly  1277 VGKQKRSALRGGESGPGGVTQDHLTVPGCEDSHSHHSLGMSSDNTTSLAATMELFTQRSEKKRLK 1341
            :  :....|   .:.|..::...|....|...|..|      ...|:.|..:..    :......
Zfish   485 I--RHECVL---PAPPLALSHPCLCAEPCYYIHISH------PGPTAAARPLPC----THTHCCP 534

  Fly  1342 KSLKKMSKAQNGVSPATATNGGADAAAL----------GDGVSAEDAARKHHKHKKRKKHKKHHR 1396
            :.:.|:..|.....|..|......||.|          ....|...:..:|
Zfish   535 RGVSKLLPATGLPHPHPAYCCLCPAARLPYTYLTLPETACSCSFSCSTSRH-------------- 585

  Fly  1397 KNGSEEQEQQVVQQDYSAAGQEATEAPSTEMSSATSSRVKVEVKVKTEQLEMEEEESASN---LM 1458
                            |:..:...:||:..:|....|...|....:    |..:....|.   |.
Zfish   586 ----------------SSRTEAPPDAPALLLSPGCPSMPLVNRSAR----ECPQNPKPSGHRPLR 630

  Fly  1459 SEISDEAKGDDLVEHNNSKGSSKIAAFLPERQLWGWYGTAYRK----AGVKGRARKQFYKTIKRG 1519
            :.......|..|...:..:         |:...|...|.:.::    ||.:....:|.|.:::|.
Zfish   631 TTRRLRPAGGVLRRRSTRR---------PDTNGWRPVGASTQRELLMAGDEQTVLRQCYDSVQRD 686

  Fly  1520 KETITVGDSAVFLSTG--RPDRPYIGRIESMW-ETTTGNKVVRVAWFYHPEETTG--CPKLKFPG 1579
            .|.|.|.|: |.|.:|  |...||:.:|.::| |..||..::.:.|:|.||.|.|  .|.:....
Zfish   687 GELIRVRDT-VLLKSGPRRKTLPYVAKISALWEEPRTGELMMSLFWYYRPEHTQGGRDPSMHCEK 750

  Fly  1580 ALFESPHEDENDVQTISHRCEVLQFGSY 1607
            .:|.|.|:|||.|..|..||.||....|
Zfish   751 EIFASRHQDENSVACIEERCYVLPLAQY 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wge	NP_732790.3	BAH_BAHCC1	1520..1642	CDD:240065	35/93 (38%)
LOC100331694	XP_005173894.1	DUF4887	161..325	CDD:292845	34/179 (19%)
LOC100331694	XP_005173894.1	BAH	687..792	CDD:295389	35/93 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583622
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840