DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4907 and PIGO

DIOPT Version :9

Sequence 1:	NP_651086.1	Gene:	CG4907 / 42686	FlyBaseID:	FBgn0039010	Length:	919	Species:	Drosophila melanogaster
Sequence 2:	NP_116023.2	Gene:	PIGO / 84720	HGNCID:	23215	Length:	1089	Species:	Homo sapiens

Alignment Length:	1005	Identity:	198/1005 - (19%)
Similarity:	339/1005 - (33%)	Gaps:	329/1005 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LLLLGSILSIYFQSTILSDLEPLSTLRELG-----LEPPA---------------------DRLV 49
            ||.|..:..:::....|.....|.|..||.     .|||.                     .|:|
Human     7 LLFLAWVCFLFYAGIALFTSGFLLTRLELTNHSSCQEPPGPGSLPWGSQGKPGACWMASRFSRVV 71

  Fly    50 VFVVDGLRAQSVLADHCS-------AVPDLRELFVEQALVGISRACPPTVTRPGHIAIFGGFNED 107
            :.::|.||.......|..       ::|.|.:|...|.::.|         :|.|..::....:.
Human    72 LVLIDALRFDFAQPQHSHVPREPPVSLPFLGKLSSLQRILEI---------QPHHARLYRSQVDP 127

  Fly   108 PAAT------LTWN--PSTFDSVFNRSRNAIGWMQAEVAKVFTHLPTGGAPLRFETFARSDISDR 164
            |..|      ||..  |:..|:..|.:.:||  ::..:.|   .|.:.|..:.|       :.|
Human   128 PTTTMQRLKALTTGSLPTFIDAGSNFASHAI--VEDNLIK---QLTSAGRRVVF-------MGD- 179

  Fly   165 LRLDQW------TFDK--------VRNFMTNE----QNVQPLRDATS-VIFFVYLADIDLAEHVH 210
               |.|      .|.|        ||:..|.:    :::.|..|:.. .:...:...:|...|.|
Human   180 ---DTWKDLFPGAFSKAFFFPSFNVRDLDTVDNGILEHLYPTMDSGEWDVLIAHFLGVDHCGHKH 241

  Fly   211 MPNSLNFREKLNYTQRGIRQTYELFESVFNDSRTAYLMTADYGISL---HGGGGERGVETPFILW 272
            .|:.....:||:...:.|:...|..|   ||  |..::..|:|::.   |||..|..|.....|:
Human   242 GPHHPEMAKKLSQMDQVIQGLVERLE---ND--TLLVVAGDHGMTTNGDHGGDSELEVSAALFLY 301

  Fly   273 GAGVKRSAPNPGQNFTAGENGPILPLYQLEQIQLAPLMSALIGLPPPMNNMALMPLGFL------ 331
                   :|......|..|...::|     |:.|.|.::.|:|||.|..|:..:.....
Human   302 -------SPTAVFPSTPPEEPEVIP-----QVSLVPTLALLLGLPIPFGNIGEVMAELFSGGEDS 354

  Fly   332 --NTSVQYELQVLHLNAMQL------------------LAQARILIKRHEDGILYLLLPKFESLG 376
              ::|...:...|||||.|:                  |.|.:.|..:......:||    :|..
Human   355 QPHSSALAQASALHLNAQQVSRFLHTYSAATQDLQAKELHQLQNLFSKASADYQWLL----QSPK 415

  Fly   377 SAEIENYPQIIKYLV-----AKEQYEEA------LKVSHKIAKLAQECM--------EYYHGYYH 422
            .|| ...|.:|..|.     |:....|:      ::::...|.||..|.        ....|:..
Human   416 GAE-ATLPTVIAELQQFLRGARAMCIESWARFSLVRMAGGTALLAASCFICLLASQWAISPGFPF 479

  Fly   423 LPLLVATTASYLVWFYLLLVRLARESNHPKSERKGYLTWTTLMMCLGGLVL-LELMILQRVPHLT 486
            .|||:...|..||                     |.:.:..|   ||.:.| |:|::|..|..::
Human   480 CPLLLTPVAWGLV---------------------GAIAYAGL---LGTIELKLDLVLLGAVAAVS 520

  Fly   487 AFYLLLPFGILILALA----ERPCQDRDLMCQFPVLHLVGIVMPGVLLILMAFHNSHIGLLYLPI 547
            :|   |||  |..|.|    :||     |...||:        ||.:|:|:.|..:
Human   521 SF---LPF--LWKAWAGWGSKRP-----LATLFPI--------PGPVLLLLLFRLA--------- 558

  Fly   548 VCLNNRRAFFRPSLKLIFWLALVFLLSG--ILLVKQSASLHFITDTI------------------ 592
                   .||..|..:....|..|||..  :|||.|   ||:....:
Human   559 -------VFFSDSFVVAEARATPFLLGSFILLLVVQ---LHWEGQLLPPKLLTMPRLGTSATTNP 613

  Fly   593 ----GVY-----IG----------------NSHVVYFSMILSIIRPLILGHQHSTRVWI-VNMAA 631
                |.|     ||                .:.|.:.|..||.:..::.|  .:..:|. ..:||
Human   614 PRHNGAYALRLGIGLLLCTRLAGLFHRCPEETPVCHSSPWLSPLASMVGG--RAKNLWYGACVAA 676

  Fly   632 LLVTAYGIYQW-------DADQPVCTYVYAACWSYLLFAFLSIPY----SGTKDLRRRLELII-- 683
            |:.....:..|       .:.:|...:|.   |...|.|..:..|    ||..:...||.:::
Human   677 LVALLAAVRLWLRRYGNLKSPEPPMLFVR---WGLPLMALGTAAYWALASGADEAPPRLRVLVSG 738

  Fly   684 FNML-------------------TVHIMLTTSIGSLFVQIMVTEFVLGLELYEESFSYANLKDAI 729
            .:|:                   .|.:::....|:...:.::|.| .|....:....|. :....
Human   739 ASMVLPRAVAGLAASGLALLLWKPVTVLVKAGAGAPRTRTVLTPF-SGPPTSQADLDYV-VPQIY 801

  Fly   730 ANQQQNNQG-LEESRNESPNNPLEHVRQSYRYAALILLYLYISFFGTGHWFFNFTFKPMTSRLFF 793
            .:.|:..:| ||.::::.|.....:...|...||::                     ...:.|.|
Human   802 RHMQEEFRGRLERTKSQGPLTVAAYQLGSVYSAAMV---------------------TALTLLAF 845

  Fly   794 PQFHLHM-LVAFILLKIFIPSIIVMSSIYA 822
            |...||. .::.:.|.:|:.|.:::..:.|
Human   846 PLLLLHAERISLVFLLLFLQSFLLLHLLAA 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4907	NP_651086.1	GPI_EPT_1	42..327	CDD:293744	72/342 (21%)
CG4907	NP_651086.1	PigN	413..858	CDD:282796	95/503 (19%)
PIGO	NP_116023.2	Npp1	42..>299	CDD:224441	58/286 (20%)
PIGO	NP_116023.2	GPI_EPT_3	65..344	CDD:293747	69/320 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1524
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810