DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4907 and Pigo

DIOPT Version :9

Sequence 1:	NP_651086.1	Gene:	CG4907 / 42686	FlyBaseID:	FBgn0039010	Length:	919	Species:	Drosophila melanogaster
Sequence 2:	NP_064419.2	Gene:	Pigo / 56703	MGIID:	1861452	Length:	1101	Species:	Mus musculus

Alignment Length:	939	Identity:	190/939 - (20%)
Similarity:	337/939 - (35%)	Gaps:	294/939 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 RLVVFVVDGLR---AQ----SVLADHCSAVPDLRELFVEQALVGISRACPPTVTRPGHIAIFGGF 104
            |:|:.::|.||   ||    .|..:...:||.|.:|...|.::         .::|.|..::...
Mouse    77 RVVLVLIDALRFDFAQPQRSHVPGEPPVSVPFLGKLGSLQRIL---------ESQPHHGRLYRSQ 132

  Fly   105 NEDPAAT------LTWN--PSTFDSVFNRSRNAIGWMQAEVAKVFTHLPTGGAPLRFETFARSDI 161
            .:.|..|      ||..  |:..|:..|.:.:||     ....|...|.:.|..:.|       :
Mouse   133 VDPPTTTMQRLKALTTGSLPTFIDAGSNFASHAI-----VEDNVIQQLNSAGRRVVF-------M 185

  Fly   162 SDRLRLDQW---------------TFDKVRNFMTNE----QNVQPLRDATS-VIFFVYLADIDLA 206
            .|    |.|               :|: ||:..|.:    :::.|..|..| .:...:...:|..
Mouse   186 GD----DTWRDLFPGAFSQAFFFSSFN-VRDLHTVDNGILEHLYPTLDGGSWDVLIAHFLGVDHC 245

  Fly   207 EHVHMPNSLNFREKLNYTQRGIRQTYELFESVFNDSRTAYLMTADYGISL---HGGGGERGVETP 268
            .|.|.|:.....:||:...:.|:   .|.|.:.||  |..::..|:|:::   |||..|..|...
Mouse   246 GHKHGPHHPEMAKKLSQMDQVIQ---GLIERLEND--TLLVVAGDHGMTMNGDHGGDSELEVSAA 305

  Fly   269 FILWGAGVKRSAPNPGQNFTAGENGPILPLYQLEQIQLAPLMSALIGLPPPMNN----MALMPLG 329
            ..|:.......:..|       |...::|     |:.|.|.::.|:|||.|..|    ||.:..|
Mouse   306 LFLYSPTALFPSVPP-------EEPEVIP-----QVSLVPTLALLLGLPIPFGNTGEVMAELFSG 358

  Fly   330 FLNTSVQY-----ELQVLHLNAMQL--------LAQARILIKRHEDGILYLLLPKFESLGSAEIE 381
            ..::|..:     ::..||:||.|:        .|...:.:|.     |:.|...| |..||..:
Mouse   359 GSDSSHPHSSALAQVSALHINAQQVSRFLHTYSAATQDLQVKE-----LHRLQTLF-SKASARYQ 417

  Fly   382 NY---PQ----IIKYLVAKEQYEEALKVSHKI-----------------AKLAQECMEYYHGYYH 422
            ::   ||    .:..|.|  ::::.|:.:..:                 |.||..|:
Mouse   418 HFLRDPQEAEAALSTLTA--EFQQFLRGARALCIESWARFSLVRMAGGAALLAAACL-------- 472

  Fly   423 LPLLVA--TTASYLVWFYLLLVRLARESNHPKSERKGYLTWTTLMMCLGGLVL-----LELMILQ 480
            |.||.:  ..|...::..|||:.:|           ..||||.|   ..|:.:     ::|::|.
Mouse   473 LCLLASQLAVAPGFLFRPLLLIPVA-----------WGLTWTIL---YAGVSVTTGSKIDLVVLG 523

  Fly   481 RVPHLTAFYLLLPFGILILALAERPCQDRDLMCQFPVLHLVGIVMPGVLLILMA----FHNSHIG 541
            .|   .|...||||  |..|...|..:.       |:..|:.:..|.::|:|:.    |.:|.:
Mouse   524 AV---AAAGSLLPF--LWKAWVSRGSKR-------PLAPLLPVPRPVLILLLIRLATFFSDSFV- 575

  Fly   542 LLYLPIVCLNNRRAFFRPSL--KLIFWLALVFLLSGILLVKQSASL-----------------HF 587
                    :...||  .|.|  .|:|:|.......|.||..:..::                 |.
Mouse   576 --------VAEARA--TPFLLGSLVFFLVAQLHWEGQLLPPKPLTMSRLGSSAPTAPPRHSGAHA 630

  Fly   588 ITDTIGVYIGNSHVVYF------------SMILSIIRPLILGHQHSTRVW----IVNMAALLVTA 636
            :...||:.:.......|            |..||.:..::.|  .:..:|    :..:.||||..
Mouse   631 LWLGIGLLLFTRLAGLFHRCPEETPACRSSPWLSPLASMVGG--RAKNLWYGACVGALVALLVVV 693

  Fly   637 ------YG----------IYQWDADQPVCTYVYAACWSYLLFAFLSIPYSGTKDLRRRLELIIFN 685
                  ||          ..:|  ..|:.....||.|:..         ||.::...||..::..
Mouse   694 RLWLRRYGNLKSPEPPVLFVRW--GMPLMVLGTAAYWALA---------SGAEEAPPRLRALVAG 747

  Fly   686 ---MLTVHIMLTTSIGSLF-----VQIMV--------TEFVL----GLELYEESFSYANLKDAIA 730
               :|...:|...::|.:.     |.::|        |..:|    |....:....|. :.....
Mouse   748 ASAVLPRAVMGLAALGLVLLLWRPVTVLVKAGAATSRTRTILTPFSGPPTSQADLDYV-VPQIYR 811

  Fly   731 NQQQNNQG-LEESRNESPNNPLEHVRQSYRYAALILLYLYISFFGTGHWFFNFTFKPMTSRLFFP 794
            :.|:..|| ||.::.:.|.....:...|...||::...|.::                     ||
Mouse   812 HMQEEFQGRLERTKAQGPITVAAYQLGSVYSAAMVTALLLLA---------------------FP 855

  Fly   795 QFHLHM-LVAFILLKIFIPSIIVMSSIYA 822
            ...||: .|:.:.|.:|:.|.:::..:.|
Mouse   856 LMLLHVERVSLVFLLLFLQSFLLLHLLAA 884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4907	NP_651086.1	GPI_EPT_1	42..327	CDD:293744	72/321 (22%)
CG4907	NP_651086.1	PigN	413..858	CDD:282796	95/494 (19%)
Pigo	NP_064419.2	Npp1	50..441	CDD:224441	91/414 (22%)
Pigo	NP_064419.2	GPI_EPT_3	72..352	CDD:293747	70/317 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1524
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810