DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4907 and pign

DIOPT Version :9

Sequence 1:	NP_651086.1	Gene:	CG4907 / 42686	FlyBaseID:	FBgn0039010	Length:	919	Species:	Drosophila melanogaster
Sequence 2:	NP_001297009.1	Gene:	pign / 556797	ZFINID:	ZDB-GENE-080204-114	Length:	932	Species:	Danio rerio

Alignment Length:	984	Identity:	272/984 - (27%)
Similarity:	472/984 - (47%)	Gaps:	155/984 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IQALVVHLLLLGSILSIYFQSTILSDLEPLSTLRELGLEPPADRLVVFVVDGLRAQSVLA---DH 65
            :..|:||::....|..|||.|.::..:.|    :.:.|.|||.|||:||.|||||.|:..   ..
Zfish     8 VVGLIVHVVFFLCIFDIYFTSPLVHGMTP----QRVSLPPPAKRLVLFVADGLRADSLFKPDDSG 68

  Fly    66 CSAVPDLRELFVEQALVGISRACPPTVTRPGHIAIFGGFNEDPAATLT-W--NPSTFDSVFNRSR 127
            .|..|.||.:..|....|:|....||.:||||:|:..||.||.:|... |  ||..||||||.||
Zfish    69 TSRAPYLRSVIEEGGTWGVSHTRVPTESRPGHVALIAGFYEDVSAVAKGWKENPVEFDSVFNESR 133

  Fly   128 NAIGWMQAEVAKVFT------HLPTGGAPLRFETFARSDISDRLRLDQWTFDKVRNFMT----NE 182
            ....|...::..:|.      |:.|...|...|.||.:|.|   |||.|.||:|::|:|    ||
Zfish   134 YTWCWGSPDILPMFAKGATGDHVYTHTYPPEREDFASTDAS---RLDTWVFDEVKDFLTAAKSNE 195

  Fly   183 QNVQPLRDATSVIFFVYLADIDLAEHVHMPNSLNFREKLNYTQRGIRQTYELFESVF-NDSRTAY 246
            ..::.|.:..:| ||::|..||...|.|.|.|....|.:.....|:.....:.:..: :|.:|||
Zfish   196 TLLKKLHEEQNV-FFLHLLGIDTNGHAHRPMSKECLENIGLVDAGVADIVTVMDDFYGHDGKTAY 259

  Fly   247 LMTADYGIS---LHGGGGERGVETPFILWGAGVKRSAPNPGQNFTAGENGPI----LPLYQ---L 301
            :.|:|:|::   .||.|......||.::|||||:::.....|.:   |:..:    |..|:   :
Zfish   260 VFTSDHGMTNWGSHGAGHPSETLTPLVVWGAGVQKAQWETSQKY---EDNYLKEWGLESYRRVDV 321

  Fly   302 EQIQLAPLMSALIGLPPPMNNMALMPLGFLNTSVQYELQVLHLNAMQLLAQARI-LIKRHEDGIL 365
            .|..:|||||:|||:|.|:|::.::||.:||.|..::.:.::.||:|:|.|.|: |.::.|..|.
Zfish   322 NQADIAPLMSSLIGIPFPLNSVGVLPLSYLNNSQHFKAESMYANAIQILEQFRVKLAQKKETTIS 386

  Fly   366 YLLLPKFESLGSAEIENYPQIIKYLVAKEQYEEALKVSHKIAKLAQECMEYYHGYYHLPLLVATT 430
            :|..| ::.|..::..::.:..:.|:.|.:::||:.....:...|.|.:.|||.|..|.|..:..
Zfish   387 FLFTP-YQPLTDSKQVDFIRQARDLIQKGRFDEAIVYCKDLIAQAMEGLSYYHTYDRLFLGSSVV 450

  Fly   431 ASYLVW-FYLLLVRLARESNHPK--------SERKGYLTWTTLMMCLGGLVLLELMILQRVPHLT 486
            ..::.| .|::|..|...::..|        :||  .|.|.  .:|:|.|:.|.|:: |..|...
Zfish   451 LGFIGWTSYVVLYILKTHASLRKPPTNTSMVTER--LLGWG--FLCVGLLMALFLLV-QSSPWSY 510

  Fly   487 AFYLLLPFGILILALAERPCQDRDLMCQFPVLHLVGIV-----MP-------------GVLLILM 533
            ..|.|:|..:....|.|           |..  |||:|     :|             |:.|::|
Zfish   511 YIYSLMPVAVWYAVLKE-----------FKT--LVGLVRSIPSLPLTKCFGYFVLVAFGIELLVM 562

  Fly   534 AFHNS---HIGLLYL---PIVCLNNRRAFF-RPSLKLIFW------LALVFLLSGILLVKQSASL 585
            :|...   .:||:.|   |:|     ..|: :...|.:.|      ||:..||.   :|.:..::
Zfish   563 SFFYRAMLSLGLVVLALWPVV-----SGFYTKAKFKSLSWTLSCLSLAVFPLLP---VVGREPNI 619

  Fly   586 HFITDTIGVYIGNSHVVYFSMILSIIR--PLILGHQHSTRVWIVNMAALLVTAYGI------YQW 642
            :::....|:.:.||.    |.:.|..|  ||:   :...:::|..|..:.:.||.:      .|.
Zfish   620 NYVISAGGLILFNSS----SFLWSSWRDSPLM---RRDRQLFIFQMVQVALCAYTLTSTHSSLQL 677

  Fly   643 DADQPVCTYVYAACWSYLLFAFLSIPYSGTKDLRRRLELIIFNMLTVHIMLTTSIGSLFVQIMVT 707
            ....|:...:.:  ||.|:.:|| ||...:..|..||..|:.::..|:::|:|...:|| .:|::
Zfish   678 KQGLPIFNQLVS--WSTLVSSFL-IPLLSSTRLFHRLLSILMSLTCVYLLLSTGHEALF-PLMLS 738

  Fly   708 EFVLGLELYEESFSYANLKDAIANQQQNNQGLEESRNE------SPNNPLEHVRQ----SYRYAA 762
            ..:|.....|:        :|::.|..:|      |||      :.|..:..|||    ..|.:.
Zfish   739 WLMLAWIHIEQ--------EAMSRQGSSN------RNELSCIDFAENIDITKVRQLRLDDIRKSY 789

  Fly   763 LILLYLYISFFGTGHWFFNFTFKPMTSRLFFPQFHLHMLVAFILLKIFIPSIIVMSSIYALVSFG 827
            ..:.::.|:|||.|:.....:|.|.:...|...|:..::...::.|:.||.:|||.:..::....
Zfish   790 FFVFFIIIAFFGCGNIASINSFDPASVYCFLTVFNPFIMGGLLMWKVLIPFVIVMCTFESIQVST 854

  Fly   828 RKNVRSIFICLFLMNDAMSLYFCYFVINRGSLEKVRESLDRLLV---SHVFIILLLVCSWI---A 886
            :.:.||:|:.:.:::|.|:|:|.:.|.:.||...:..|:...::   ..:|::||.|.:.|   .
Zfish   855 QLSSRSLFLIVLVISDLMALHFFFLVKDYGSWLDIGTSISHYVIVMSMTIFLMLLSVMTHILTSK 919

  Fly   887 KGFLANTKK 895
            |..|..::|
Zfish   920 KILLGRSRK 928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4907	NP_651086.1	GPI_EPT_1	42..327	CDD:293744	111/311 (36%)
CG4907	NP_651086.1	PigN	413..858	CDD:282796	117/502 (23%)
pign	NP_001297009.1	Npp1	11..>282	CDD:224441	98/278 (35%)
		GPI_EPT_1	42..347	CDD:293744	111/311 (36%)
		PigN	433..885	CDD:282796	117/502 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596001
Domainoid	1	1.000	122	1.000	Domainoid score	I5581
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55072
OrthoDB	1	1.010	-	-		D141925at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm25781
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12250
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2480
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.960