Protein Alignment CG4907 and PIGG

DIOPT Version :10

• Sequence 1: NP_651086.1
• Gene: CG4907 / 42686
• FlyBaseID: FBgn0039010
• Length: 919
• Species: Drosophila melanogaster
• Sequence 2: NP_001120650.1
• Gene: PIGG / 54872
• HGNCID: 25985
• Length: 983
• Species: Homo sapiens
• Alignment Length: 725
• Identity: 153/725 - (21%)
• Similarity: 258/725 - (35%)
• Gaps: 209/725 - (28%)

  Fly     3 SIQALVVHLLLLGSILSIYFQSTILSDLEPLSTLRELGLEPPA-------------------DRL 48
            :|:.|.:.:.|.|     :|.:.:.|     |...|.|.||||                   .::
Human    14 AIEVLGIAVFLRG-----FFPAPVRS-----SARAEHGAEPPAPEPSAGASSNWTTLPPPLFSKV 68

  Fly    49 VVFVVDGLRAQSVLADHCSAVPDLRELFVEQALVG--ISRACPPTVTR-----------PGHIAI 100
            |:.::|.||...|...............||:....  ::.|.|||||.           ||.:.:
Human    69 VIVLIDALRDDFVFGSKGVKFMPYTTYLVEKGASHSFVAEAKPPTVTMPRIKALMTGSLPGFVDV 133

  Fly   101 FGGFNEDPAATLTWNPSTFDSVFNRSRNAIG----------WMQAEVAKVFTHLPTGGAPLRFET 155
            ....|         :|:..:....|...|.|          |:     |:|        |..|..
Human   134 IRNLN---------SPALLEDSVIRQAKAAGKRIVFYGDETWV-----KLF--------PKHFVE 176

  Fly   156 FARSD---ISDRLRLDQWTFDKVRNFMTNEQNVQPLRDATSVIFFVYLADIDLAEHVHMPNSLNF 217
            :..:.   :||        :.:|.|.:|...:....|....::...||. :|...|:..|||...
Human   177 YDGTTSFFVSD--------YTEVDNNVTRHLDKVLKRGDWDILILHYLG-LDHIGHISGPNSPLI 232

  Fly   218 REKLNYTQRGIRQTYELFESVFNDSRTAYLMT--ADYGIS---LHGGGGERGVETPFILWGAGVK 277
            .:||:.....:.:.:...:|...::....|:.  .|:|:|   .||......|.||.||..:..:
Human   233 GQKLSEMDSVLMKIHTSLQSKERETPLPNLLVLCGDHGMSETGSHGASSTEEVNTPLILISSAFE 297

  Fly   278 RSAPNPGQNFTAGENGPILPLYQLEQIQLAPLMSALIGLPPPMNNMA--LMPLGFLNTSVQYELQ 340
            |            :.|.|.....::|..:|..::..:|||.|.:::.  |.|: .....::.:|:
Human   298 R------------KPGDIRHPKHVQQTDVAATLAIALGLPIPKDSVGSLLFPV-VEGRPMREQLR 349

  Fly   341 VLHLNAMQLLAQARILIKRHEDGILYLLLPKFESLGSAEIENYPQIIKYLVAKEQYEEAL-KVSH 404
            .||||.:||   :::|   .|:...|...|.||....:|..:...|..||  :|::.|.| .:..
Human   350 FLHLNTVQL---SKLL---QENVPSYEKDPGFEQFKMSERLHGNWIRLYL--EEKHSEVLFNLGS 406

  Fly   405 KIAKLAQECMEYYHGYYHLPL-LVATTASYLVWFYLLLVRLARESNHPKSERKGYLTWTTLMMCL 468
            |:.:      :|......|.| |.|..|.|.::                            .|.:
Human   407 KVLR------QYLDALKTLSLSLSAQVAQYDIY----------------------------SMMV 437

  Fly   469 GGLVLLELMILQRVPHLTAFYLLLPFGILILALAERPCQDRDLMCQFPVLHLVGIVMPGVLLILM 533
            |.:|:||:        ||...|.:|..:...|..|.|.........|.:          |:|:|.
Human   438 GTVVVLEV--------LTLLLLSVPQALRRKAELEVPLSSPGFSLLFYL----------VILVLS 484

  Fly   534 AFHNSHIGLLYLPIVCLNNRRAFFRPSLKLIFWLALVFLLSGILLVKQSASLHFITDTI-GVYIG 597
            |.|         .|||.:...:.:...|.   |||     :|.::|..||.|..|...: .|.:|
Human   485 AVH---------VIVCTSAESSCYFCGLS---WLA-----AGGVMVLASALLCVIVSVLTNVLVG 532

  Fly   598 NS----HVVYFSMILSIIRPLIL----GH------------QHSTRVWIVNMAALLV---TAYGI 639
            .:    :.::.|...|.:..|||    ||            :|.|..::||...|.:   |....
Human   533 GNTPRKNPMHPSSRWSELDLLILLGTAGHVLSLGASSFVEEEHQTWYFLVNTLCLALSQETYRNY 597

  Fly   640 YQWDADQPVC 649
            :..|..:|.|
Human   598 FLGDDGEPPC 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4907	NP_651086.1	GPI_EPT_1	42..327	CDD:293744	66/336 (20%)
		PigN	412..858	CDD:461508	56/263 (21%)
PIGG	NP_001120650.1	GPI_EPT_2	62..335	CDD:293748	61/315 (19%)
		PIGO_PIGG	<803..965	CDD:437148