DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4907 and Pigg

DIOPT Version :9

Sequence 1:	NP_651086.1	Gene:	CG4907 / 42686	FlyBaseID:	FBgn0039010	Length:	919	Species:	Drosophila melanogaster
Sequence 2:	NP_001297618.1	Gene:	Pigg / 433931	MGIID:	3576484	Length:	983	Species:	Mus musculus

Alignment Length:	1022	Identity:	199/1022 - (19%)
Similarity:	341/1022 - (33%)	Gaps:	330/1022 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SIQALVVHLLLLGSILSIYFQSTILSDL-----------EPLSTLRE--LGLEPPA-DRLVVFVV 53
            :|:.:.|.:.:.|     :|.:.:.|..           ||::.:|.  ..|.||. .::|:.::
Mouse    14 AIEVIGVAIFIRG-----FFPAPVRSSARPEHDAETPAPEPVAGVRSNWTKLPPPLFSKVVIVLI 73

  Fly    54 DGLRAQSVLADHCSAVPDLRELFVEQALVG--ISRACPPTVTR-----------PGHIAIFGGFN 105
            |.||...|...............||:....  ::.|.|||||.           ||.:.:....|
Mouse    74 DALRDDFVFGSKGVKYMPYTTYLVEKGASHSFVAEAKPPTVTMPRIKALMTGSLPGFVDVIRNLN 138

  Fly   106 EDPAATLTWNPSTFDSVFNRSRNAIG----------WMQAEVAKVFTHLPTGGAPLRFETFARSD 160
                     :|...:....|...|.|          |:     |:|        |..|..:..:.
Mouse   139 ---------SPVLLEDNVLRQAKAAGKRIIFYGDETWV-----KLF--------PKHFVEYDGTT 181

  Fly   161 ---ISDRLRLDQWT---FDKVRNFMTNEQNVQPLRDATSVIFFVYLADIDLAEHVHMPNSLNFRE 219
               :||.:.:|:..   .|||..           |....|:...||. :|...|:..|||.....
Mouse   182 SFFVSDYIEVDKNVTRHLDKVLK-----------RGDWDVLILHYLG-LDHIGHISGPNSPLIGH 234

  Fly   220 KLNYTQRGIRQTYELFESVFNDSRTAYL-----MTADYGIS---LHGGGGERGVETPFILWGAGV 276
            ||:.....:   .::..|:.:..|...|     :..|:|:|   .||......|.||.:|..:..
Mouse   235 KLSEMDSVL---MKIHTSLLSKDRETLLPSLLVLCGDHGMSETGSHGASSTEEVSTPLLLISSAF 296

  Fly   277 KRSAPNPGQNFTAGENGPILPLYQLEQIQLAPLMSALIGLPPPMNNMA--LMPLGFLNTSVQYEL 339
            :|            :.|.|.....::|..||..::..:|||.|.:::.  |.|: .....::.:|
Mouse   297 ER------------KPGDIRHPKHVQQTDLAATLAIGLGLPIPKDSVGSLLFPV-IEGKPMREQL 348

  Fly   340 QVLHLNAMQLLAQARILIKRHEDGILYLLLPKFESLGSAEIENYPQIIKYLVAKEQYEEALKVSH 404
            :.||||.:||   :::|.:.         :|.:|                   |:...|..|::.
Mouse   349 RFLHLNTLQL---SKLLQEN---------VPSYE-------------------KDPGFEQFKMAE 382

  Fly   405 KIAKLAQECMEYYHGYYHLPLLVATTASYLVWFYLLLVRLARESNHPKSERKGYLTWTTLMMCLG 469
            |:           ||.:                    |:|..|.||  |:....|....|...||
Mouse   383 KL-----------HGNW--------------------VKLHLEENH--SDILLGLGTKVLRHYLG 414

  Fly   470 GLVLLELMILQRVPHLTAFYL----LLPFGILILALAERP---CQDRDLMCQFPVLHLV-GIVMP 526
            .|..|.|.:..:|.....:.:    |:...:|.|.|...|   |:..:|  ..|:|..| .::..
Mouse   415 ALKTLSLSLSTQVAQYDMYSMAVGTLIVLEVLALFLLSTPHVLCRKAEL--DVPLLSPVFSLLFY 477

  Fly   527 GVLLILMAFHNSHIGLLYLPIVCLNNRRAFFRPSLKLIFWL---ALVFLLSGILLVKQSASLHFI 588
            .|.|:|.|.|         .:||.::..:.:..||.   ||   |::.|:|.:.....||.:..:
Mouse   478 LVFLVLSAIH---------VLVCTSSESSCYLCSLS---WLAVGAVMLLVSALFCAILSALIRMV 530

  Fly   589 TD-------------------------TIG--------VYIGNSHVVYFSMILSI--------IR 612
            .|                         |:|        .::...|..::.:|.::        .|
Mouse   531 IDSTLLKKNAADASSGWSEVNLLLLLGTVGHVLSLGASSFVEEEHQTWYFLINTLCLALSQETCR 595

  Fly   613 PLILG-------HQHSTRVWIVNMAAL---------------------LVTAYGIYQWDADQPVC 649
            ...||       |.| .....||:.|.                     |:.|.|..:|
Mouse   596 SYFLGDECEPQRHSH-VEQQCVNLLACPLQDSTSYNTPESGTAGKRVSLLEAQGSCKW------- 652

  Fly   650 TYVYAACWSYLLFAFL--SIPYSGTKDLRR--------------RLELIIFNMLTVHIMLTTSIG 698
            ..|.|:.|..||...|  |:..:|.:...|              :|..:....|.|..||.....
Mouse   653 WTVLASPWLVLLCCRLLRSLNQTGVQGAHRPDFSHWLTSSDHKVQLSGLAALSLVVIFMLVQRRC 717

  Fly   699 SLFVQIMVTEFVLGLELYEESFSYANLKDAIANQQQNNQGLEESRNESPNNPLEHVRQSYRYAAL 763
            ||..::.:...:||:..|..:.......     .|.:|:|:.:...|:            |:  :
Mouse   718 SLVSKVALALGLLGVFCYRAAIGIVQFP-----WQSDNKGISKGIIEA------------RF--V 763

  Fly   764 ILLYLYISFFGTGHWF----FNFTFKPMTSRLFFPQFHLHMLVAFILLKIFIPSIIVMSSIYALV 824
            .:..|.|.|.||....    ....||..|..|:.....|.:|.|.:|....:| ::..|.:.
Mouse   764 YVFVLGILFTGTKDLLKAQVIATDFKTKTVGLWEMHSGLVLLAALLLRPHNLP-VLAFSLLI--- 824

  Fly   825 SFGRKNVRSIFICLFLMNDAMSL---------YFCYFVINRGSLEKV 862
                :.|.:.||...|.:||..:         .|.||..|..::..:
Mouse   825 ----QTVMTKFIWKPLRHDAAEITVMHYWFGQAFFYFQGNSNNIATI 867

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4907	NP_651086.1	GPI_EPT_1	42..327	CDD:293744	67/324 (21%)
CG4907	NP_651086.1	PigN	413..858	CDD:282796	108/553 (20%)
Pigg	NP_001297618.1	GPI_EPT_2	62..335	CDD:293748	66/321 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1524
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810