DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4907 and CG13978

DIOPT Version :9

Sequence 1:	NP_651086.1	Gene:	CG4907 / 42686	FlyBaseID:	FBgn0039010	Length:	919	Species:	Drosophila melanogaster
Sequence 2:	NP_651562.2	Gene:	CG13978 / 43303	FlyBaseID:	FBgn0039518	Length:	898	Species:	Drosophila melanogaster

Alignment Length:	922	Identity:	448/922 - (48%)
Similarity:	619/922 - (67%)	Gaps:	38/922 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWSIQALVVHLLLLGSILSIYFQSTILSDLEPLSTLRELGLEPPADRLVVFVVDGLRAQSVLADH 65
            ||.:||||||:||:|:||:.|||.|:|.:|.|..|:||||||||||||||||.|||||.:.||::
  Fly     1 MWKLQALVVHILLMGAILNTYFQHTLLPNLVPQKTMRELGLEPPADRLVVFVTDGLRAATFLANN 65

  Fly    66 CSAVPDLRELFVEQALVGISRACPPTVTRPGHIAIFGGFNEDPAAT---LTWNPSTFDSVFNRSR 127
            .|.||||::::.:|..:||||.|.||:|||||||||.||:|||||:   |.:||..||:||||||
  Fly    66 GSDVPDLKDIYRQQGRIGISRTCAPTMTRPGHIAIFAGFHEDPAASLMHLCYNPGDFDTVFNRSR 130

  Fly   128 NAIGWMQAEVAKVFTHLPTGGAPLRFETFARSDISDRLRLDQWTFDKVRNFMTNEQNVQPLRDAT 192
            |.|||..:.:...|..|..|||||||:::...|:.::|..|:|.||||.||:.|..||:..|:..
  Fly   131 NMIGWAHSYIVGYFVKLSHGGAPLRFDSYMERDLPEKLTCDKWAFDKVENFLRNVDNVREWRNYK 195

  Fly   193 SVIFFVYLADIDLAEHVHMPNSLNFREKLNYTQRGIRQTYELFESVFNDSRTAYLMTADYGIS-- 255
            ..:|||||||:|:|.|...|.|..|..||.|||||||.||||||.||||||||||||:|:|::
  Fly   196 PAVFFVYLADMDIAAHRFKPLSKKFFAKLQYTQRGIRNTYELFERVFNDSRTAYLMTSDHGMNNE 260

  Fly   256 -LHGGGGERGVETPFILWGAGVKRSAPNPGQNFTAGENGPILPLYQLEQIQLAPLMSALIGLPPP 319
             .||.|....||||..:|||||||...:...||....|     :.|::|.|||||||:|||||||
  Fly   261 GAHGSGSPLEVETPLFMWGAGVKRDEIDAEANFPEKPN-----ISQVDQTQLAPLMSSLIGLPPP 320

  Fly   320 MNNMALMPLGFLNTSVQYELQVLHLNAMQLLAQARILIKRHEDGILYLLLPKFESLGSAEIENYP 384
            .||:||||:|:||.|.:|:...||||.:|||:||.|||.|||..|.|..||||:.|....|:.|.
  Fly   321 KNNLALMPVGYLNVSDEYQAVALHLNVLQLLSQAEILIGRHEKAIFYKWLPKFKELHIGVIDQYA 385

  Fly   385 QIIKYLVAKEQYEEALKVSHKIAKLAQECMEYYHGYYHLPLLVATTASYLVWFYLLLVRLARESN 449
            .....|.::....:|::...:..|||::|:.||:.||..||:||.:.||::|||.||::|.|.|.
  Fly   386 AQFDILKSEGNLTDAMEFCKEYGKLAKKCLTYYNQYYQTPLIVANSMSYMIWFYCLLLQLTRLSK 450

  Fly   450 HPKSERKGYLTWTTLMMCLGGLVLLELMILQRVPHLTAFYLLLPFGILILALAERPCQDRDLMCQ 514
            ..|.:|:|::|.:||::.:.|::|:.:|.||:|||:.||||:||.|:||:|.||||.  |.....
  Fly   451 KEKMQRRGFMTVSTLILAMIGILLIAMMELQKVPHIAAFYLILPVGMLIMAQAERPV--RGYWIF 513

  Fly   515 FPVLHLVGIVMPGVLLILMAFHNSHIGLLYLPIVCLNNRRAFFRPSLKLIFWLALVFLLSGILLV 579
            .|:.:...|::|.||::.|.|...|:.:||...|.||||||..:||:||..||:|..:::.||.:
  Fly   514 HPLWNFGFILVPAVLIMSMTFIIRHLWVLYGISVLLNNRRALRKPSIKLFIWLSLALIVTAILFM 578

  Fly   580 KQSASLHFITDTIGVYIGNSHVVYFSMILSIIRPLILGHQHSTRVWIVNMAALLVTAYGIYQWDA 644
            :|.......|..:..|    ||:|.||:|:|||||||||:|..|||..|...|:|.|:|:||:..
  Fly   579 EQRTIKGLKTIPVKDY----HVLYVSMVLAIIRPLILGHRHDPRVWTFNSLTLVVGAFGVYQYKF 639

  Fly   645 DQPVCTYVYAACWSYLLFAFLSIPY--SGTKDLRRRLELIIFNMLTVHIMLTTSIGSLFVQIMVT 707
            .:.|.:|||...||:|.||||||.|  ....:.|:|||||..||:||..:||.|.|.|..||.:|
  Fly   640 YESVSSYVYVVTWSFLFFAFLSIVYFAKSLPEARKRLELITINMITVLSLLTNSWGCLNFQIAIT 704

  Fly   708 EFVLGLELYEESFSYANLKDAIANQQQNNQGLEESRNESPNNPLEHVRQSYRYAALILLYLYISF 772
            ||:.||::|||:              :..:.:|::::|  :..|::::..|||..:||||.|:||
  Fly   705 EFIFGLQIYEET--------------KETKEIEDAKDE--HTSLQNLKGFYRYGYMILLYFYVSF 753

  Fly   773 FGTGHWFFNFTFKPMTSRLFFPQFHLHMLVAFILLKIFIPSIIVMSSIYALVSFGRKNVRSIFIC 837
            |..|||..:|.|||.|:|||:|.|.|::..:.:||||||||:|.:.::||:|.|.|||.|||.|.
  Fly   754 FLAGHWISSFLFKPTTARLFYPHFSLYIAGSLVLLKIFIPSVIFICALYAMVPFVRKNARSILIS 818

  Fly   838 LFLMNDAMSLYFCYFVINRGSLEKVRESLDRLLVSHVFIILLLVCSWIAKGFLANTKKDKPTPRA 902
            :|::::||.||..||:.||||..|:|..||::|::|....:||:...:||.|||||..::|..:
  Fly   819 IFMISNAMGLYQYYFIRNRGSWRKIRMFLDQILLTHAVNFMLLLGISLAKIFLANTTMERPGQK- 882

  Fly   903 PVQAVTNNANLA 914
              :|.|..:|||
  Fly   883 --RARTTRSNLA 892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4907	NP_651086.1	GPI_EPT_1	42..327	CDD:293744	164/290 (57%)
CG4907	NP_651086.1	PigN	413..858	CDD:282796	199/446 (45%)
CG13978	NP_651562.2	GPI_EPT_1	42..328	CDD:293744	164/290 (57%)
CG13978	NP_651562.2	PigN	414..839	CDD:282796	199/446 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45470298
Domainoid	1	1.000	69	1.000	Domainoid score	I2673
eggNOG	1	0.900	-	-		E1_COG1524
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	327	1.000	Inparanoid score	I529
Isobase	1	0.950	-	0	Normalized mean entropy	S1579
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D141925at33208
OrthoFinder	1	1.000	-	-		FOG0014321
OrthoInspector	1	1.000	-	-		otm2513
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12250
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2480
	11	10.850