DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4907 and PIG-O

DIOPT Version :9

Sequence 1:	NP_651086.1	Gene:	CG4907 / 42686	FlyBaseID:	FBgn0039010	Length:	919	Species:	Drosophila melanogaster
Sequence 2:	NP_611332.1	Gene:	PIG-O / 37118	FlyBaseID:	FBgn0034346	Length:	1077	Species:	Drosophila melanogaster

Alignment Length:	1118	Identity:	206/1118 - (18%)
Similarity:	344/1118 - (30%)	Gaps:	417/1118 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 ILSDLEPLSTLRELGLEPPADRLVVFVVDGLRAQSVL--ADHCSAVPDLRELFVEQALVGIS--- 85
            |..|:...|.|    ..|...:::|.|||.|:.:..|  |:....:|...:|.|.|.|:..:
  Fly    61 IFKDVNASSNL----CLPQKSKVIVLVVDALKYEFGLYRANATDPLPYENKLVVLQELLQQNPDH 121

  Fly    86 ------RACPPTVT-----------RPGHIAIFGGF-----NED-----------PAATL---TW 114
                  ||.|||.|           .|..|.|...|     |||           |...|   ||
  Fly   122 ARLMRFRADPPTTTLQRLKGLTTGSLPTFIDIGSNFASPEINEDNIIDQIVKNDLPVVFLGDSTW 186

  Fly   115 N---PSTFDSVFNRSRNAIGWMQAEVAKVFTHLPTGGAPLRFETFARSDISDRLRLDQWTFDKVR 176
            .   |..|...::.....|..:.:...::..|||                 ..|....|.
  Fly   187 TDLYPHRFKRSYSYPSFDIFDLDSVDNEILKHLP-----------------KELESKDWQ----- 229

  Fly   177 NFMTNEQNVQPLRDATSVIFFVYLADIDLAEHVHMPNSLNFREKLNYTQRGIRQTYELFESVFND 241
                              :...:...:|...|.|.|.......||......||......     |
  Fly   230 ------------------VLVAHFLGVDHCGHKHGPMHEEMARKLGEMNEVIRSVVAAM-----D 271

  Fly   242 SRTAYLMTADYGISLHGG-GGERGVETPFILWGAGVKRSAPNPGQNFTAGENGPILPLYQLEQIQ 305
            :.|..|:..|:|::..|. ||:...||..:|:       |.:....|...::|....:  |:||.
  Fly   272 NDTTLLVMGDHGMTASGDHGGDTDDETNALLF-------AYSKQHRFYGNDSGSDSEM--LQQID 327

  Fly   306 LAPLMSALIGLPPPMNNMALMPLGFLNTSVQYELQVLHLNAMQLLAQARILIKRHEDGILYLLLP 370
            |.|.::.::|:|.|.:|     ||.:|.::..:|:|.|||
  Fly   328 LVPTLATILGVPIPYSN-----LGLVNFNIVPDLRVPHLN------------------------- 362

  Fly   371 KFESLGSAEIENYPQIIKYLVAKEQY-----------------EEALKVSHKIAKLAQE------ 412
            ||::|.....:|..||.:|..   ||                 .|.:.::|::..:..|
  Fly   363 KFQTLLLHSWQNAQQIYRYFF---QYALENKRTFNVEQMDHLETEFILLTHRVQTVYNEVAFKSF 424

  Fly   413 --------------CMEYYHGYYHLPLLVATTASYL-VWFYLLLVRLARESNHP----------- 451
                          |.|.:..:....:......::| ::|..|:|..:|.::.|
  Fly   425 VRDLNTNLRDILGTCREIWVRFDPTQMSQGLLFTFLPLFFIFLVVNNSRPADFPHIFKAKEVFYV 489

  Fly   452 --------------------KSERKGYL-----------------TWT----------------T 463
                                |:|.:|.:                 .||                |
  Fly   490 YLINLAAGVFGYRYFKTFSFKTEEQGVIFFTAISSAVILAFHTLRHWTSIATNWSAVKRFGHMPT 554

  Fly   464 LMMCLGGL--------VLLELMILQRVPHLTAFYLLLPFGILILALAERPCQDRDLMCQFPVLHL 520
            .::..|.:        |:.|..||..:  |.|..|||...:|.|: |....:.:....||.....
  Fly   555 RLLLFGSMAVFFSNSFVIQEAKILSYL--LAAAILLLSHELLRLS-ARLDFRTKFKASQFLRSTA 616

  Fly   521 VGIVMPGVLLILMAFHNSHIGLLYLPIVC----------LNNRRAFF---RPSLKLIFWLALVFL 572
            :.:::..||.|.:      |...|....|          :|...|.|   :|.....:.||:|.|
  Fly   617 LRLILASVLAICL------IRFAYTLFRCREEQGNCSDFVNTGGAGFSLKKPGTGKTYILAVVVL 675

  Fly   573 --------------------LSGILLVKQSASLHFITDTIGVYIGNSHVVYFSMILSIIRPLILG 617
                                |..:||.:...::..|.....:.:.||.:
  Fly   676 VVYTTLTRLYLRSCGNLTGNLPNVLLARYGPTVASICAGGHILLANSSI---------------- 724

  Fly   618 HQHSTRVWIVNMA----ALLVTAYGIYQWDADQPVCTYVYAACWSYL------------LFAFLS 666
             :|..|..|..||    .||:....:..|   .|:.|:|.....|:.            :|..:.
  Fly   725 -KHIQRTHIDAMALVIYGLLLVQIIVLSW---APLMTFVLPPRSSHTVTINGNESIVPEIFRKMK 785

  Fly   667 IPYSGTKDLRRRLELIIFNMLTVHIMLTTSIGSLFVQIMVT----EFVLGLEL------------ 715
            ..|.|..|.||....:::.:.||:..:..:.|.....:|:.    ...:||.:
  Fly   786 RMYEGDDDERRSHIPVVYGLATVYSSIVIAFGVFLALVMIVLLEPRASIGLVVCVAVGAILLSVH 850

  Fly   716 ----YEESFSYANLKDAIANQQQNNQGLEESRNESPNNPLEHVRQSYRYAALI--LLYLYISFFG 774
                |..:.|:                      ||...|        .:.||:  .|..:..||.
  Fly   851 SILRYRTATSF----------------------ESCVQP--------TFTALVGWFLLAHFCFFA 885

  Fly   775 TGHWFFNFTFKPMTSRLFF-------PQFHLHMLVAFILLKIFIPSIIVMSSIYALVSFGRKNVR 832
            |.|   ..|...:..|..|       .|.:| :..|.::|..|...|... .:|:|:|....::.
  Fly   886 TSH---QTTLSQIEWRAAFVGRTTGIGQSNL-VSGALVILNTFCGPIFFF-CMYSLLSTETFSLF 945

  Fly   833 SIFICLF-----------------LMNDAMSLYFCYFVINRGSL-----EKVRESLDRLLVSHVF 875
            ::|..|.                 |.|:|:.     |.:.||.|     |.|.......|.:..|
  Fly   946 ALFPNLIRSCRSGGKVDASTSMSDLANEAVG-----FDMTRGELSLYEYEDVFLGTGFKLATQFF 1005

  Fly   876 II--LLLVCSWIA 886
            ::  |.:.|:.:|
  Fly  1006 MLQGLKIFCAMLA 1018

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4907	NP_651086.1	GPI_EPT_1	42..327	CDD:293744	69/329 (21%)
CG4907	NP_651086.1	PigN	413..858	CDD:282796	104/612 (17%)
PIG-O	NP_611332.1	GPI_EPT_3	74..349	CDD:293747	71/333 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1524
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810