DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4907 and Pign

DIOPT Version :9

Sequence 1:	NP_651086.1	Gene:	CG4907 / 42686	FlyBaseID:	FBgn0039010	Length:	919	Species:	Drosophila melanogaster
Sequence 2:	NP_038812.2	Gene:	Pign / 27392	MGIID:	1351629	Length:	931	Species:	Mus musculus

Alignment Length:	953	Identity:	247/953 - (25%)
Similarity:	459/953 - (48%)	Gaps:	106/953 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LVVHLLLLGSILSIYFQSTILSDLEPLSTLRELGLEPPADRLVVFVVDGLRAQSVL---ADHCSA 68
            |::|.:...||..|||.|.::..:.|..|    .|.|||.|||:||.|||||.::.   .|..|.
Mouse     9 LLIHFVFFASIFDIYFTSPLVHGMTPQFT----PLPPPAKRLVLFVADGLRADTLYELDEDGNSR 69

  Fly    69 VPDLRELFVEQALVGISRACPPTVTRPGHIAIFGGFNEDPAATLT-W--NPSTFDSVFNRSRNAI 130
            .|.:|.:.:.:...|:|....||.:||||:|:..||.||.:|... |  ||..|||:||.|:...
Mouse    70 APFIRNVIMHEGSWGVSHTRVPTESRPGHVALIAGFYEDVSAVAKGWKENPVEFDSLFNESKYTW 134

  Fly   131 GWMQAEVAKVFT------HLPTGGAPLRFETFARSDISDRLRLDQWTFDKVRNFMTNEQNVQPL- 188
            .|...::..:|.      |:.|.....:.|.|...|.:   :||.|.||||::|....:|.|.|
Mouse   135 SWGSPDILPMFAKGASGDHVYTYSYDAQREDFGAHDAT---KLDTWVFDKVKDFFDAARNNQSLF 196

  Fly   189 --RDATSVIFFVYLADIDLAEHVHMPNSLNFREKLNYTQRGIRQTYELFESVF-NDSRTAYLMTA 250
              .:...|:||::|..||...|.|.|:|..:::.:.....|:::...:|:..: :|.:||::.|:
Mouse   197 TKVNEEKVVFFLHLLGIDTNGHAHRPSSREYKDNIKKVDDGVKEIVSIFKHFYGDDGKTAFIFTS 261

  Fly   251 DYGIS---LHGGGGERGVETPFILWGAGVKRSAPNPGQNFTAGE-NGPILPLYQLE--------Q 303
            |:|::   .||.|......|||:.||||:|..     ||.:|.: :...|..::||        |
Mouse   262 DHGMTDWGSHGAGHPSETLTPFVTWGAGIKFP-----QNVSAQQYDDEFLKEWRLENWKRRDVNQ 321

  Fly   304 IQLAPLMSALIGLPPPMNNMALMPLGFLNTSVQYELQVLHLNAMQLLAQARILIKRHEDGILYLL 368
            ..:||||::|||:|.|:|::.::|:|:||.:..::.:.:..||:|:|.|.::.:.:.::..|..|
Mouse   322 ADIAPLMASLIGVPFPLNSVGILPVGYLNNTGLFKAESMFTNAVQILEQFKVKMTQKKEATLPFL 386

  Fly   369 LPKFESLGSAEIENYPQIIKYLVAKEQYEEALKVSHKIAKLAQECMEYYHGYYHLPLLVATTASY 433
            ...|:.|..::..:..:..:..:.:|:::|.:.:..::..||...:.|||.|..|.|.:.....:
Mouse   387 FTPFKLLSDSQQLDILRKARSYIKQEKFDEVVSLCEELIDLALRGLSYYHTYDRLFLGINVAVGF 451

  Fly   434 LVWF-YLLLVRLARESNHPKSERK-GYLTWTTLM---MCLGGLVLLELMILQRVPHLTAFYLLLP 493
            :.|. |..|:.:...||.||..|| |......|:   :..|.||...||| |..|.....|.|||
Mouse   452 VGWMSYTSLLIIKSHSNIPKGTRKEGKKPHCLLLYSFIATGVLVACFLMI-QACPWTYYVYCLLP 515

  Fly   494 FGILILALAERP-CQDR-DLMCQFPVLHLVGIVMP---GVLLILMAFHNSHI---GLLYL---PI 547
            ..|....|.|.. .||. :.:..||..|.|..::.   |:.:::::|...::   ||:..   |.
Mouse   516 VPIWYAVLREHEVIQDLVESLLTFPRSHFVAYLLVFTLGIEVLVLSFFYRYMLTAGLIVFAGWPF 580

  Fly   548 VCLNNRRAFFRPSLKLIFW-----LALVFLLSGILLVKQSASLHFITDTIGVYIGNSHVVYFSMI 607
            :    .:.:.|..:..:.|     |..||.|..::..|.:.||         .:|...:|   ::
Mouse   581 L----TQLWTRAKITFLSWAFFSLLLAVFPLMPVVGRKPNLSL---------VMGAGFLV---LL 629

  Fly   608 LSIIRPLILGHQH------STRVWIVNMAALLVTAYGIYQW------DADQPVCTYVYAACWSYL 660
            ||:.....||.::      ...|.::.|.:.:::.|.:|..      ....|:...:.:  |:.|
Mouse   630 LSLAVVTTLGKRNIKLVKGELLVLLLQMLSTVLSMYVVYSTHHSLLKKEGLPLMNQIVS--WATL 692

  Fly   661 LFAFLSIPYSGTKDLRRRLELIIFNMLTVHIMLTTSIGSLFVQIMVTEFVLGLELYEESFSY--A 723
            ..:.:: |...:..|.:||..|:.::::.:::|:|...:||..::.....:.:::.:|:...  .
Mouse   693 ASSLVA-PLLSSTALSQRLASILLSLMSTYLLLSTGYEALFPLVLSCLMFVWIQVEQETLQQPGV 756

  Fly   724 NLKDAIANQQQN-NQGLEESRNESPNNPLEHVRQSYRYAALILLYLYISFFGTGHWFFNFTFKPM 787
            :.|..:.:.|.. :..:.:.|...|::        .|.|..::.:|..:|||||:.....:|...
Mouse   757 SCKQKLTSIQFTCDTDIAQFRQLCPDD--------IRRAFFLVFFLLTAFFGTGNIASINSFDLA 813

  Fly   788 TSRLFFPQFHLHMLVAFILLKIFIPSIIVMSSIYALVSFGRKNVRSIFICLFLMNDAMSLYFCYF 852
            :...|...|...|:.|.::.||.||.::||.:..|:....:.:.:.:|:.:.:::|.|:|:|.:.
Mouse   814 SVYCFLTVFSPFMMGALMMWKILIPFVLVMCAFEAVQITTQLSSKGLFLVVLIISDIMALHFFFL 878

  Fly   853 VINRGSLEKVRESLDRLLVSHVFIILLLVCSWIAKGFLANTKK 895
            |.:.||...:..|:...::.....|.|:..:.:|:  |..|||
Mouse   879 VKDSGSWLDIGTSISHYVIVMSMTIFLVFLNGLAQ--LLTTKK 919

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4907	NP_651086.1	GPI_EPT_1	42..327	CDD:293744	104/312 (33%)
CG4907	NP_651086.1	PigN	413..858	CDD:282796	105/480 (22%)
Pign	NP_038812.2	GPI_EPT_1	40..345	CDD:293744	104/312 (33%)
Pign	NP_038812.2	PigN	431..884	CDD:368221	105/480 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850138
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1524
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1579
OMA	1	1.010	-	-		QHG55072
OrthoDB	1	1.010	-	-		D141925at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42624
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12250
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2480
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.810