DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4907 and ENPP4

DIOPT Version :9

Sequence 1:	NP_651086.1	Gene:	CG4907 / 42686	FlyBaseID:	FBgn0039010	Length:	919	Species:	Drosophila melanogaster
Sequence 2:	NP_055751.1	Gene:	ENPP4 / 22875	HGNCID:	3359	Length:	453	Species:	Homo sapiens

Alignment Length:	430	Identity:	87/430 - (20%)
Similarity:	130/430 - (30%)	Gaps:	160/430 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LVVHLLLLGSILSIYFQSTILSDLEPLSTLRELGLEPPADRLVVFVVDGLRAQSVLADHCSAVPD 71
            |:|.||..|.|..  |:|...|.|.|              :|::...||.|| ..|.::  ..|.
Human     3 LLVILLFSGLITG--FRSDSSSSLPP--------------KLLLVSFDGFRA-DYLKNY--EFPH 48

  Fly    72 LRELFVEQALVGISRACPPTVTRPGHIAIFGGFNEDPAATLT----------------------W 114
            |:....|..||...:....|.|.|.|.:|..|..|:....:.                      |
Human    49 LQNFIKEGVLVEHVKNVFITKTFPNHYSIVTGLYEESHGIVANSMYDAVTKKHFSDSNDKDPFWW 113

  Fly   115 NPS-----TFDSVFNRSRNAIGWMQAEVA-----------------------KVFTHLPTGGAPL 151
            |.:     |.....|||..|..|...:|.                       .:...|.....|:
Human   114 NEAVPIWVTNQLQENRSSAAAMWPGTDVPIHDTISSYFMNYNSSVSFEERLNNITMWLNNSNPPV 178

  Fly   152 RF--------------------ETFAR---------SDISDRLR-LDQWTFDKVRNFMTNEQNV- 185
            .|                    |..:|         .|:..||: |..|  :.:...:|::..:
Human   179 TFATLYWEEPDASGHKYGPEDKENMSRVLKKIDDLIGDLVQRLKMLGLW--ENLNVIITSDHGMT 241

  Fly   186 ----QPLRDATSVIFFVYLADIDLAEHVHMPNSLNFREKLN-----------YTQRGI--RQTYE 233
                ..|.:..|.|...|...|||:....:...:|..|..|           |.:..|  |..|:
Human   242 QCSQDRLINLDSCIDHSYYTLIDLSPVAAILPKINRTEVYNKLKNCSPHMNVYLKEDIPNRFYYQ 306

  Fly   234 LFESVFNDSRTAYLMTADYG--ISLHGGG---GERGVET------PFI-----LWGAGVKRSAPN 282
                 .||.....::.||.|  |.|:...   |:.|.:.      ||:     .:..|.|.|..|
Human   307 -----HNDRIQPIILVADEGWTIVLNESSQKLGDHGYDNSLPSMHPFLAAHGPAFHKGYKHSTIN 366

  Fly   283 PGQNFTAGENGPILPLYQLEQIQLAPLMSALIGLPPPMNN 322
                        |:.:|        |:|..::||.|..||
Human   367 ------------IVDIY--------PMMCHILGLKPHPNN 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4907	NP_651086.1	GPI_EPT_1	42..327	CDD:293744	76/395 (19%)
CG4907	NP_651086.1	PigN	413..858	CDD:282796
ENPP4	NP_055751.1	Enpp	26..379	CDD:293742	72/396 (18%)
ENPP4	NP_055751.1	Phosphodiest	28..339	CDD:279931	61/320 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1524
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900