DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4907 and Enpp3

DIOPT Version :9

Sequence 1:	NP_651086.1	Gene:	CG4907 / 42686	FlyBaseID:	FBgn0039010	Length:	919	Species:	Drosophila melanogaster
Sequence 2:	NP_598766.2	Gene:	Enpp3 / 209558	MGIID:	2143702	Length:	874	Species:	Mus musculus

Alignment Length:	621	Identity:	113/621 - (18%)
Similarity:	184/621 - (29%)	Gaps:	253/621 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 PPADRLVVFVVDGLRAQSVLADHCSAVPDLRELFVEQALVGI----SRACPPTVTRPGHIAIFGG 103
            ||   :::|.:||.||: .|....:.:|::.:|    ...||    .||..||.|.|.|..|..|
Mouse   159 PP---VILFSMDGFRAE-YLQTWSTLLPNINKL----KTCGIHSKYMRAMYPTKTFPNHYTIVTG 215

  Fly   104 FNEDPAATLTWNPSTFDSVFNRS--------RNAIGW---------MQAEVAKVFTHLP------ 145
            ...:....:..|  .:|...|::        .|...|         |...:.....:.|
Mouse   216 LYPESHGIIDNN--MYDVHLNKNFSLSSVEKSNPAWWSGQPIWLTAMYQGLKAACYYWPGSDVAV 278

  Fly   146 TGGAPLRFETFARSDISDR--LRLDQWTFDKVRNFMTNEQNVQPLRDATSVIFFVYLADIDLAEH 208
            .|..|..:..::.|...:|  ..|.|| .|            .|..|..| .:.:|:.:.|.|.|
Mouse   279 NGSFPTIYRNYSNSVPYERRITTLLQW-LD------------LPKADRPS-FYTIYVEEPDSAGH 329

  Fly   209 VHMP-----------------------------NSLN----------------------FREKLN 222
            ...|                             |.:|                      :..|:|
Mouse   330 SSGPVSAGVIKALQSVDNAFGMLMEGLKQRNLHNCVNIIVLADHGMDQTSCDRVEYMTDYFPKIN 394

  Fly   223 Y----------TQRGIRQTYELFES---VFN------DSRTAYLMTADYGISLHGGGGERGVETP 268
            :          ..|.|.|.:..|.|   |.|      |......:|.|....||.....| ::..
Mouse   395 FYMYQGPAPRIRTRNIPQDFFTFNSEEIVRNLSCRKPDQHFKPYLTPDLPKRLHYAKNVR-IDKA 458

  Fly   269 FIL----WGAGVKRSAPNPGQNFTAGEN-------------GP-------ILPLYQLEQIQLAPL 309
            .::    |.|...:.:.|.|.. |.|.|             ||       |.|   .|.|::..|
Mouse   459 HLMVDRQWLAFRSKGSSNCGGG-THGYNNEFKSMEAIFLAHGPSFIEKTVIEP---FENIEVYNL 519

  Fly   310 MSALIGLPPPMNNMA------LMPLGFLNTSVQYEL----------------------------- 339
            :..|:.:.|..||..      |:...|...|...||
Mouse   520 LCDLLHIEPAPNNGTHGSLNHLLKTPFYKPSHAGELSTPADCGFTTPLPTDPLDCSCPALQNTPG 584

  Fly   340 ------QVLHLNAMQLLA---------QARILIKRHEDGILY-----------LLLPKFES---L 375
                  |.|:|:..::.|         :.|::.|..:..:||           :.:|.:.|   |
Mouse   585 LEEQANQRLNLSEGEVAATVKANLPFGRPRVMQKNGDHCLLYHRDYISGYGKAMKMPMWSSYTVL 649

  Fly   376 GSAEIENYPQIIKYLVAKEQYEEALKVSHKIA-KLAQECMEYY------HGYYHLPLLVATTASY 433
            ...:..:.|..:         .:.|:...::| ..:|:|..|.      ||:.: |.:..|..|.
Mouse   650 KPGDTSSLPPTV---------PDCLRADVRVAPSESQKCSFYLADKNITHGFLY-PAIKGTNESR 704

  Fly   434 L-----------------VWFY---LLLVRLARESN 449
            .                 :|.|   :||::.|.|.|
Mouse   705 YDALITSNLVPMYKEFKKMWDYFHEVLLIKYAIERN 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4907	NP_651086.1	GPI_EPT_1	42..327	CDD:293744	80/412 (19%)
CG4907	NP_651086.1	PigN	413..858	CDD:282796	14/63 (22%)
Enpp3	NP_598766.2	SO	50..93	CDD:197571
		Cell attachment site. /evidence=ECO:0000255	78..80
		SO	94..137	CDD:197571
		Phosphodiesterase	140..509		70/375 (19%)
		Enpp	159..525	CDD:293742	76/394 (19%)
		Phosphodiest	161..485	CDD:279931	65/346 (19%)
		Nuclease	605..874		25/146 (17%)
		NUC	627..856	CDD:214683	21/124 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1524
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900