DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4907 and Enpp1

DIOPT Version :9

Sequence 1:	NP_651086.1	Gene:	CG4907 / 42686	FlyBaseID:	FBgn0039010	Length:	919	Species:	Drosophila melanogaster
Sequence 2:	NP_001295256.1	Gene:	Enpp1 / 18605	MGIID:	97370	Length:	906	Species:	Mus musculus

Alignment Length:	563	Identity:	117/563 - (20%)
Similarity:	171/563 - (30%)	Gaps:	200/563 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LLGSILSIY-----FQSTILSDLEPLST-------LRELGLEPP--------------------A 45
            :|..|..:|     |:..||:.||.|..       ...|.||.|                    .
Mouse   314 ILPDIYKVYNGSVPFEERILAVLEWLQLPSHERPHFYTLYLEEPDSSGHSHGPVSSEVIKALQKV 378

  Fly    46 DRLVVFVVDGLRAQSVLADHCSAVPDLRELFVEQALVGISRACPPTVTRPGHI-------AIFGG 103
            ||||..::|||:...:  |.|..:..:.:..:||.      :|...|....::       .::|
Mouse   379 DRLVGMLMDGLKDLGL--DKCLNLILISDHGMEQG------SCKKYVYLNKYLGDVNNVKVVYG- 434

  Fly   104 FNEDPAATL--TWNPSTFDSVFNRSRNAIGWMQAEVAKVFTHLPTGGAPLRFETFARSDISDRLR 166
                |||.|  |..|.|:.| ||                            :|..|
Mouse   435 ----PAARLRPTDVPETYYS-FN----------------------------YEALA--------- 457

  Fly   167 LDQWTFDKVRNFMTNEQNVQPLRDATSVIFFVYLADIDLAEHVHMPNSLNFREKLNYTQRGIRQT 231
                     :|....|.|..         |..||...       :|..|:|.:    :.|....|
Mouse   458 ---------KNLSCREPNQH---------FRPYLKPF-------LPKRLHFAK----SDRIEPLT 493

  Fly   232 YEL---FESVFNDSRTAYLMTADYGISLHGGGG-ERGVETPFILWGAGVKRSAPNPGQNFTAGEN 292
            :.|   ::...|.|...|.     |...||... ...::..||.:|...|..|
Mouse   494 FYLDPQWQLALNPSERKYC-----GSGFHGSDNLFSNMQALFIGYGPAFKHGA------------ 541

  Fly   293 GPILPLYQLEQIQLAPLMSALIGLPPPMNNMALMPLGFLNTSVQYELQVLHLNAMQLLAQARILI 357
                .:...|.|::..||..|:||.|..||.:...|..|.....|...  |......|:|..|..
Mouse   542 ----EVDSFENIEVYNLMCDLLGLIPAPNNGSHGSLNHLLKKPIYNPS--HPKEEGFLSQCPIKS 600

  Fly   358 KRHEDGIL----YLLLPKFESLGSAEIENYPQIIKYLVAKEQYEEALKVSHKIAKLAQECMEYYH 418
            ..::.|..    .:.:..||...:...|:...|....|...:....|| .|::..|.|:  ::..
Mouse   601 TSNDLGCTCDPWIVPIKDFEKQLNLTTEDVDDIYHMTVPYGRPRILLK-QHRVCLLQQQ--QFLT 662

  Fly   419 GYYHLPLLVATTASY---------------------------------------LVWFYLLLVRL 444
            | |.|.||:...|||                                       |.:.:|...||
Mouse   663 G-YSLDLLMPLWASYTFLSNDQFSRDDFSNCLYQDLRIPLSPVHKCSYYKSNSKLSYGFLTPPRL 726

  Fly   445 ARESNHPKSERKGYLTWTTLMMCLGGLVL---LELMILQRVPH 484
            .|.|||..||  ..||...:.|.....|:   |...:|||..|
Mouse   727 NRVSNHIYSE--ALLTSNIVPMYQSFQVIWHYLHDTLLQRYAH 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4907	NP_651086.1	GPI_EPT_1	42..327	CDD:293744	61/317 (19%)
CG4907	NP_651086.1	PigN	413..858	CDD:282796	27/114 (24%)
Enpp1	NP_001295256.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		Di-leucine motif. /evidence=ECO:0000269\|PubMed:11598187, ECO:0000269\|PubMed:15075217	27..34
		SO	86..126	CDD:197571
		SO	127..170	CDD:197571
		Phosphodiesterase. /evidence=ECO:0000305\|PubMed:23027977, ECO:0000305\|PubMed:23041369	173..573		72/359 (20%)
		Enpp	192..560	CDD:293742	67/346 (19%)
		Phosphodiest	194..520	CDD:279931	57/290 (20%)
		Linker. /evidence=ECO:0000305\|PubMed:23027977, ECO:0000305\|PubMed:23041369	579..628		8/50 (16%)
		Nuclease. /evidence=ECO:0000305\|PubMed:23027977, ECO:0000305\|PubMed:23041369	635..906		33/139 (24%)
		NUC	657..888	CDD:214683	28/116 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1524
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900