DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4907 and pign-1

DIOPT Version :9

Sequence 1:	NP_651086.1	Gene:	CG4907 / 42686	FlyBaseID:	FBgn0039010	Length:	919	Species:	Drosophila melanogaster
Sequence 2:	NP_001249296.1	Gene:	pign-1 / 171881	WormBaseID:	WBGene00021840	Length:	912	Species:	Caenorhabditis elegans

Alignment Length:	1028	Identity:	252/1028 - (24%)
Similarity:	432/1028 - (42%)	Gaps:	228/1028 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WS--IQALVVHLLLLGSILSIYFQSTILSDLEPLSTLRELGLEPPADRLVVFVVDGLRAQSVLAD 64
            |.  |.::.|||:|:.||..:|:.|.::..:.|.....:   |.||.|:.:...||||     .|
Worm     3 WKFLIASITVHLVLIYSIFDVYYTSPLVHGIPPQFINSQ---EAPAKRIFIISADGLR-----YD 59

  Fly    65 HCSAVPD----LRELFVE-QALVGISRACPPTVTRPGHIAIFGGFNEDPAATLT-W--NPSTFDS 121
            ..:..||    |..:..| :.:.|:||:..||.:||||:|||.|..||.:|... |  ||..|||
Worm    60 TFNKYPDKSPYLHSIMNERKGIYGLSRSHIPTESRPGHVAIFAGITEDISAVAKGWKKNPVQFDS 124

  Fly   122 VFNRSRNAIGWMQAEVAKVFTHLPTGGAPLRF------ETFARSDISDRLRLDQWTFDKVRNFM- 179
            |||||..:..|...::..:|..||...:   |      |.||..|.|:   ||:|.|:...||:
Worm   125 VFNRSSYSWMWGSPDIVNLFDDLPNAES---FSYSADEEDFASKDASN---LDKWVFEHFENFLE 183

  Fly   180 ---TNEQNVQPLRDATSVIFFVYLADIDLAEHVHMPNSLNFREKLNYTQRGIRQTYELFESVFND 241
               |:|.....:|:..| |||::|..||...|.:.|.|..:.:.:.....||.:...|.::.|.|
Worm   184 TAKTDEALNDKMREQKS-IFFLHLLGIDTNGHGNKPMSRQYIDNIKVVDSGIEKVQHLVDAFFGD 247

  Fly   242 SRTAYLMTADYGIS---LHGGGGERGVETPFILWGAGVKRSAPNPGQNFTAGENGPILPLYQLEQ 303
            .:||:|.|:|:|::   .||.|.:..|.|||:.||||||:..|.                ..|.|
Worm   248 HKTAWLFTSDHGMTDWGSHGAGSDDEVLTPFVAWGAGVKQGGPK----------------LDLNQ 296

  Fly   304 IQLAPLMSALIGLPPPMNNMALMPLGFLNT-SVQYELQVLHLNAMQLLAQARILIKRHEDGILYL 367
            |.||||:|||||.|.|:|:|.::|:..:|: ...||.:.:..|..||..|. |.:|..:...|:
Worm   297 IDLAPLISALIGCPIPVNSMGILPVQMMNSKGSSYEFKAIEANFKQLKEQI-IFLKNAKSRRLW- 359

  Fly   368 LLPKFESLGSAEIENYPQIIKYLVAKEQYEEALKVSHKIAKLAQECMEYYHGYYHLPLLVATTAS 432
             ..:||..|...:|:....:..|....::..|..:....|.|.:|.:.:||.|....|..|.:.|
Worm   360 -FRQFEKFGDKAMESLRTTLAQLGRDRRFSVATSLFADNAHLMKEAIVFYHRYDRQMLGAAVSCS 423

  Fly   433 YLVWFYLLLVRLARESNHPKSERKGYLTWTTLMMCLGGLVLLELMILQRVPHLTAFYLLLPFGIL 497
            ::.|..|::..|     |..:.::.                |.|:    |||   ...::|....
Worm   424 FVAWIALVVSFL-----HNSTSKEN----------------LSLL----VPH---HLFIIPLACS 460

  Fly   498 ILALAERPCQDRDLMCQFPVLHLVGIVMPGVLLILMAFHN-------SHIGLLYLPIVCLN---N 552
            :|..|         .|...:...:.|::|..|:.::..|:       .|:..|......||   :
Worm   461 LLFTA---------YCSLSMTQTIYIILPIYLISILENHSKLTQRIREHVKALSAQPDWLNKVLS 516

  Fly   553 RRAFFRPSLKLI----------------FWLALVFLLSGILLVKQSASLHFIT------------ 589
            ...|.:|.|..:                .:||.||:|  ::.:.|..|...::
Worm   517 VEVFVKPFLGFVGFSITICIFVLTFMDRAFLAAVFVL--LMALPQFYSHPIVSYWSKTWLTLCLV 579

  Fly   590 -------DTIGVYIGNSHVVYFSMILSIIRPLI---LGHQHSTR-------------VWIVNMAA 631
                   ..:||   ::|:.     |.|:.|:|   |.|:.|.|             :::.:..|
Worm   580 LCIFPFLPAVGV---STHIP-----LCILSPIITAFLCHRLSRRSCLTRIQRMLELMIYVQSATA 636

  Fly   632 LLVTA--YGIYQW-----------DADQPVCTYVYAA----------CWSYLLFAFLSIPYSGTK 673
            .::..  ||..::           |.:...|.....|          |...:|.....:|||
Worm   637 FMIAVVNYGFEKFAATVNCSMDLLDLNPTFCDCSVVAHGSISCGSSNCIRLMLLCEKIVPYS--- 698

  Fly   674 DLRRRLELIIFNMLTVHIMLTTSIGSLFVQIMVTEFVLGLELYEESFSYANLKDAIANQQQNNQG 738
                              :|:.|..|||:.|    |::.|.|:.. |.:.:|.|.        :.
Worm   699 ------------------LLSISYESLFMLI----FLVLLTLFVR-FEFGHLSDV--------EL 732

  Fly   739 LEESRNESPNNPLEHVRQSYRYAALILLYLYISFFGTGHWFFNFTFKPMTSRLFFPQFHLHMLVA 803
            |:...:.:..:..|:|  ..|...:.:.::....||||::....:|.|.|..||...|....:..
Worm   733 LQLKVDSTKISTGEYV--ELRRTVVCVSFVLCPLFGTGNFASINSFNPSTLNLFISVFSPFTMAI 795

  Fly   804 FILLKIFIPSIIVMSSIYALVSFGRKNVRSIFICLFLMNDAMSLYFCYFVINRGSLEKVRESLDR 868
            .::||:.||.::|.|:..::|.|.:::::.:.....:..|.||:.|.:.:.:.||...:..|:.:
Worm   796 LLILKLLIPILLVTSAFASIVRFDQESIQRLCCFSLIFTDFMSMCFFHQLRDEGSWLDIGMSISQ 860

  Fly   869 LLVSHVFIILLLVCSWIAKGFLANTKKDKPTPR--APVQAVTNNANLAQDSQA 919
            .:||....:.||:...|:...:|...:..|..|  ..::::::. .|:.|..|
Worm   861 FIVSMCISLALLLLLSISSHLMAFEFRKFPGKRNHQEIESISSR-KLSDDESA 912

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4907	NP_651086.1	GPI_EPT_1	42..327	CDD:293744	110/305 (36%)
CG4907	NP_651086.1	PigN	413..858	CDD:282796	97/528 (18%)
pign-1	NP_001249296.1	GPI_EPT_1	42..320	CDD:293744	110/305 (36%)
pign-1	NP_001249296.1	PigN	404..850	CDD:368221	97/528 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160167302
Domainoid	1	1.000	94	1.000	Domainoid score	I4699
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	368	1.000	Inparanoid score	I1241
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55072
OrthoDB	1	1.010	-	-		D141925at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm14712
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12250
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2480
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	10.010