DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4907 and pigg

DIOPT Version :9

Sequence 1:	NP_651086.1	Gene:	CG4907 / 42686	FlyBaseID:	FBgn0039010	Length:	919	Species:	Drosophila melanogaster
Sequence 2:	XP_005173129.1	Gene:	pigg / 100538291	ZFINID:	ZDB-GENE-141215-6	Length:	972	Species:	Danio rerio

Alignment Length:	1067	Identity:	224/1067 - (20%)
Similarity:	372/1067 - (34%)	Gaps:	341/1067 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWSIQALVVHLLLLGSILSIYFQSTILSDLEPLSTLRELGLEP------------PA---DRLVV 50
            ::::..|::.::.:...|..:|...:.|.....|.:.::..||            ||   .|:|:
Zfish     7 VFALLCLILEIVSIALFLRGFFPVPVKSSFSAKSKVTDIPAEPQTGNNAVNSSRAPALLFKRVVI 71

  Fly    51 FVVDGLRAQSVLADHCSAVPDLRELFVEQALVG--ISRACPPTVTRPGHIAIFGGFNEDPAATLT 113
            .::|.||...|.:.:...........||:....  |::|.|||||.|          ...|.|..
Zfish    72 VLIDALREDFVFSSNGRRFMPYTRHVVEKGSSHSFIAKARPPTVTMP----------RIKALTTG 126

  Fly   114 WNPSTFDSVFNRSR------NAIGWMQAEVAKVFTHLPTGGAPLRF---ETFARSDISDRLRLDQ 169
            ..|...|.|.|.:.      |.| | ||:.|         |..:.|   :|:.|......:..|.
Zfish   127 SIPGFIDVVMNLNSPVLLEDNLI-W-QAKSA---------GKRIIFYGDDTWVRLFPKHFMEQDG 180

  Fly   170 WT------FDKVRNFMTNEQNVQPLRDATSVIFFVYLADIDLAEHVHMPNSLNFREKLNYTQRGI 228
            .|      :.:|.|.:|...:....||...::...||. :|...|:..|:|.....||......|
Zfish   181 TTSFFVSDYTEVDNNVTRHLDSTLKRDDWDILILHYLG-LDHIGHISGPHSSLIGPKLMEMDDII 244

  Fly   229 RQTYELFESVFNDSRTAYLMT--ADYGIS---LHGGGGERGVETPFILWGAGVKRSAPNPGQNFT 288
            ::.:....|..::.....|:.  .|:|:|   .|||..|:.:.|..:|.....:|.
Zfish   245 KKIHASLISKESEGTLPNLLVVCGDHGMSETGSHGGSSEQEINTALVLISPAFRRK--------- 300

  Fly   289 AGENGPILPLYQLEQIQLAPLMSALIGLPPPMNNMA-LMPLGFLNTSVQYELQVLHLNAMQL--L 350
            .|...|.:    :||:.|||.::..:|||...|::. |:|..|...|::.:|::|.:|..||  |
Zfish   301 VGLERPAV----VEQVDLAPTLALGLGLPISQNSVGRLIPAVFEELSMREQLRMLQINGHQLSQL 361

  Fly   351 AQARILIKRHEDGILYLLLPKFESLGSAEIE-----------NYPQIIKYLVAK--EQYEEALK- 401
            .|....:...|||        :|....||..           |..:::..:..|  :||.:|||
Zfish   362 LQDSNPVFHKEDG--------YEQFRVAEKAHGSWMKLYVDGNKSEVLSNMGKKVRKQYLDALKA 418

  Fly   402 VSHKIAKLAQECMEYYHGYYHL-PLLVATTASYLVWFYLLLVRLARESNHPKSERKGYLTWTTLM 465
            :|..::|        ..|.|.| .:::|.|....|.|.|||..       |::..:..:....|.
Zfish   419 MSSALSK--------QMGKYDLYSMIIAMTFILQVLFLLLLAM-------PEALSRDAVVDVPLA 468

  Fly   466 MCLGGLVLLELMILQRVPHLTAFYLLLPFG----ILILALAERPCQDRDLMCQFP---------- 516
            ..|..|               .||||..||    :|:...|..||    .:|..|
Zfish   469 SSLLSL---------------PFYLLCLFGSALHVLVCTSAGGPC----YLCSLPWVLVFSVILL 514

  Fly   517 ----VLHLVGIV---------------------MPGVLLILMAFHNSHIG------------LLY 544
                ...|||:.                     :..:||....||...:|            ...
Zfish   515 SSAFTCALVGMAARRLPTSNKTPTKSSGWALSELDALLLTGTVFHTLSLGSSSFIEEEHQTWYFL 579

  Fly   545 LPIVCLN-----NRRAF-------------------------FRPSLKLIF------WLAL---V 570
            |..:||.     .||.|                         |.|:|:|..      ||||   :
Zfish   580 LNTLCLAVFQDVCRRYFREQRQGGEEEDEGPLLPSASDAGLSFSPALELGVSAGSEKWLALGTPL 644

  Fly   571 FLLSGILLVK-------QSASL----HFITDTIGVYIGNSHVVYFSMI--LSIIRPLILGHQHST 622
            ..|:...|::       |.|.|    |::.       ...|.|:.|::  :|::..|:|..:|.:
Zfish   645 LTLTCCRLLRALNQTGVQWAHLPDFGHWLN-------SGDHKVFLSVLAAVSLLLILVLVQRHCS 702

  Fly   623 RVWIVNMAALLVTAYGIYQWDA------------DQPVCTYVYAACWSYLLFAFLSIPYSGTKDL 675
               :|:..||.:...|:|.:.|            .:.|......|.:.|:.  .|.|.::|.|||
Zfish   703 ---LVSKIALTLGLLGVYSYRAAVGNVLFPWPHSSRQVSKGTVEARFVYVF--VLGILFTGVKDL 762

  Fly   676 RR-----------RLE------------LIIFNMLTVHIMLTTSIGSLFVQIMVTEFVLGLELYE 717
            .|           ||:            |::..:...| .|.|....|.||.::.:|:.....|:
Zfish   763 LRSQVMSSAVDSGRLKSRGLWEVYSGVVLLVALLFRAH-NLPTLACCLLVQTIMAQFIWKKLHYD 826

  Fly   718 ------------ESFSYANLKDAIANQQQNNQGLE---------ESRNESPNNPLEHVRQSYRYA 761
                        ::|.|       .....||.|..         ||..|:|...|..:.   .||
Zfish   827 AAQTTIMHYWFGQAFFY-------FQGNSNNIGTVDISVGFVGLESYVEAPAIILTALS---TYA 881

  Fly   762 ALIL----LYLYIS------FFGTGHWFFNFTFKPMTSRLFFPQFHLHMLVAFILLKIFIPSI-- 814
            ..:|    |..|:|      ..|.||..:.|........:|:.     :||..:...:||.|:
Zfish   882 GPLLWACHLLCYLSSQTDRVVNGLGHGSYCFALLRSIPAVFYV-----VLVTALRYHLFIWSVFS 941

  Fly   815 --IVMSSIYALVSFGRKNVRSIFICLF 839
              ::..:::.|:        :..:|||
Zfish   942 PKLLYEAMHTLI--------TTVVCLF 960

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4907	NP_651086.1	GPI_EPT_1	42..327	CDD:293744	76/322 (24%)
CG4907	NP_651086.1	PigN	413..858	CDD:282796	118/601 (20%)
pigg	XP_005173129.1	Npp1	28..>286	CDD:224441	64/279 (23%)
pigg	XP_005173129.1	GPI_EPT_2	66..335	CDD:293748	71/303 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1524
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810