Protein Alignment Cyp6d4 and CYP4F2

DIOPT Version :10

• Sequence 1: NP_651082.1
• Gene: Cyp6d4 / 42682
• FlyBaseID: FBgn0039006
• Length: 515
• Species: Drosophila melanogaster
• Sequence 2: NP_001073.3
• Gene: CYP4F2 / 8529
• HGNCID: 2645
• Length: 520
• Species: Homo sapiens
• Alignment Length: 517
• Identity: 142/517 - (27%)
• Similarity: 230/517 - (44%)
• Gaps: 62/517 - (11%)

  Fly     4 LILLAVTLL---TLAWFYLKRHYEYWER-RGFP-------FEKHSGIPFGCLDSVWRQEKSMGLA 57
            |:|:..:.|   .|||.|  ..|:...| |.||       |..|.|:.         .....|:.
Human    22 LLLVGASWLLAHVLAWTY--AFYDNCRRLRCFPQPPRRNWFWGHQGMV---------NPTEEGMR 75

  Fly    58 IYDVYVKSKERVLGIYL-LFRPAVLIRDADLARRVLAQDFASFHDRGVYVDEERDP-LSANIFSL 120
            :....|.:..:...::: ...|.:.:...|:.|.|:... |:...:..:.....:| |...:...
Human    76 VLTQLVATYPQGFKVWMGPISPLLSLCHPDIIRSVINAS-AAIAPKDKFFYSFLEPWLGDGLLLS 139

  Fly   121 RGQSWRSMRHMLSPCFTSGKLK---SMFSTSEDIGDKMVAHLQKELPEEGFKEVDIKKVMQNYAI 182
            .|..|...|.||:|.|....||   .:|:.|.:|   |.|..|. |..||...:|:.:.:....:
Human   140 AGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNI---MHAKWQL-LASEGSACLDMFEHISLMTL 200

  Fly   183 DIIASTIFGLDVNSFENPDNKFRKLVSL-ARANNRFNAM---FGMMIFLVPSIAQFLFRIGFKNP 243
            |.:...:|..|.:..|.|......::.| |..:.|.:.:   ...:.:|.|...:|.......:.
Human   201 DSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLHIDFLYYLTPDGQRFRRACRLVHD 265

  Fly   244 VGLAMLQIVKETVEYREKHGIVRKDLLQLLIQLRNTGKIDENDEKSFSIQKTPDGHIKTISLEAI 308
            ...|::|..:.|:   ...|:  .|.||...:.:....||     ...:.|..||  |.:|.|.|
Human   266 FTDAVIQERRRTL---PSQGV--DDFLQAKAKSKTLDFID-----VLLLSKDEDG--KKLSDEDI 318

  Fly   309 TAQAFIFYIAGQETTGSTAAFTIYELAQYPELLKRLQDEVDETLAKNDGK-ITYDSLNKMEFLDL 372
            .|:|..|...|.:||.|..::.:|.||::||..:|.:.||.|.|...:.| |.:|.|..:.||.:
Human   319 RAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDLAHLPFLTM 383

  Fly   373 CVQETIRKYPGLPILNRECTQDYTVPDTNHVIPKGTPVVISLYGIHHDAEYFPDPETYDPERFSE 437
            |::|::|.:|.:|:::|..|||..:|| ..|||||...:||::|.||:...:||||.|||.||..
Human   384 CMKESLRLHPPVPVISRHVTQDIVLPD-GRVIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDP 447

  Fly   438 ES-RNYNPTAFMPFGEGPRICIAQRMGRINSKLAIIKILQNFNV-----------EVMSRSE 487
            |: :..:|.||:||..|||.||.|.......|:.:...|..|.|           |::.|:|
Human   448 ENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFRVLPDHTEPRRKPELVLRAE 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d4	NP_651082.1	CYP6-like	66..504	CDD:410679	125/444 (28%)
CYP4F2	NP_001073.3	CYP4F	74..515	CDD:410772	126/454 (28%)