Protein Alignment Cyp6d4 and TBXAS1

DIOPT Version :9

• Sequence 1: NP_651082.1
• Gene: Cyp6d4 / 42682
• FlyBaseID: FBgn0039006
• Length: 515
• Species: Drosophila melanogaster
• Sequence 2: NP_001159725.2
• Gene: TBXAS1 / 6916
• HGNCID: 11609
• Length: 579
• Species: Homo sapiens
• Alignment Length: 590
• Identity: 159/590 - (26%)
• Similarity: 268/590 - (45%)
• Gaps: 112/590 - (18%)

  Fly     5 ILLAVTLLTLAWFYLKRHYEYWERRGFPFEKHSGIPF-GCLDSVWRQ---EKSMGLAIYDVYVKS 65
            :.|:|.||.|..:|....:...|:.|....|.|  || |.| :.:||   |..|.|.      |.
Human    18 VALSVALLALLKWYSTSAFSRLEKLGLRHPKPS--PFIGNL-TFFRQGFWESQMELR------KL 73

  Fly    66 KERVLGIYLLFRPAVLIRDADLARRVLAQDFASFHDR---GVYVDEERDPLSANIFSLRGQSWRS 127
            ...:.|.||..|..::|.:.|:.::||.::|::|.:|   |:    |...::.::..||.:.|..
Human    74 YGPLCGYYLGRRMFIVISEPDMIKQVLVENFSNFTNRMASGL----EFKSVADSVLFLRDKRWEE 134

  Fly   128 MRHMLSPCFTSGKLKSM------------------------FSTSEDIG---------------- 152
            :|..|...|:..||..:                        ...|:..|
Human   135 VRGALMSAFSPEKLNELGLLIMQERIKGHMGGQQAPQRIPPTRLSKPSGIYVNLHYATLPFCMVP 199

  Fly   153 ------DKMVAHLQKELPEEGFKEVDIKKVMQNYAIDIIASTIFGLDVNSFENPDNKFRKLVSLA 211
                  |.::||| |...|.| ...||::...||..|::||..||..|:|::.|::.|   |...
Human   200 LISQACDLLLAHL-KRYAESG-DAFDIQRCYCNYTTDVVASVAFGTPVDSWQAPEDPF---VKHC 259

  Fly   212 RANNRFNAMFGMMIFLV--PSIAQFLFRI----------GFKNPVGLAMLQIVKETVEYREKHGI 264
            :....|.....:::.|:  |||...|.||          ||.|       ::::..:..|::...
Human   260 KRFFEFCIPRPILVLLLSFPSIMVPLARILPNKNRDELNGFFN-------KLIRNVIALRDQQAA 317

  Fly   265 V--RKDLLQLLIQLRNTGK---IDEND-----------EKSFSIQKTPDGHIKTISLEAITAQAF 313
            .  |:|.||:::..|::..   :.:.|           :.:.|.|..|....:.::::.|..|||
Human   318 EERRRDFLQMVLDARHSASPMGVQDFDIVRDVFSSTGCKPNPSRQHQPSPMARPLTVDEIVGQAF 382

  Fly   314 IFYIAGQETTGSTAAFTIYELAQYPELLKRLQDEVDETLAKNDGKITYDSLNK-MEFLDLCVQET 377
            ||.|||.|...:|.:|..|.||..|:..::|..|||....|:... .:.||.: :.:||:.:.||
Human   383 IFLIAGYEIITNTLSFATYLLATNPDCQEKLLREVDVFKEKHMAP-EFCSLEEGLPYLDMVIAET 446

  Fly   378 IRKYPGLPILNRECTQDYTVPDTNHVIPKGTPVVISLYGIHHDAEYFPDPETYDPERFSEESR-N 441
            :|.||......||..||..|  ....||.|..:.:::..:|||.|::|.|||::||||:.|:| .
Human   447 LRMYPPAFRFTREAAQDCEV--LGQRIPAGAVLEMAVGALHHDPEHWPSPETFNPERFTAEARQQ 509

  Fly   442 YNPTAFMPFGEGPRICIAQRMGRINSKLAIIKILQNFNVEVMSRSEIEFE-NSGIALIPKHGVRV 505
            :.|..::|||.|||.|:..|:|.:..||.::.:|..|..:....:::..: .|..||.||:||.:
Human   510 HRPFTYLPFGAGPRSCLGVRLGLLEVKLTLLHVLHKFRFQACPETQVPLQLESKSALGPKNGVYI 574

  Fly   506 RLSKR 510
            ::..|
Human   575 KIVSR 579

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d4	NP_651082.1	p450	58..500	CDD:278495	135/521 (26%)
TBXAS1	NP_001159725.2	p450	47..576	CDD:306555	150/556 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920