Protein Alignment Cyp6d4 and CYP4F12

DIOPT Version :10

• Sequence 1: NP_651082.1
• Gene: Cyp6d4 / 42682
• FlyBaseID: FBgn0039006
• Length: 515
• Species: Drosophila melanogaster
• Sequence 2: NP_076433.3
• Gene: CYP4F12 / 66002
• HGNCID: 18857
• Length: 524
• Species: Homo sapiens
• Alignment Length: 537
• Identity: 147/537 - (27%)
• Similarity: 228/537 - (42%)
• Gaps: 100/537 - (18%)

  Fly     4 LILLAVT---LLT--LAWFYL---------------KRHYEYWERRGFPFEKHSGIPFGCLDSVW 48
            |:||.|.   ||.  |||.|.               ||:: :|...|.......|:......|.
Human    20 LLLLLVVGSWLLARILAWTYAFYNNCRRLQCFPQPPKRNW-FWGHLGLITPTEEGLKNSTQMSA- 82

  Fly    49 RQEKSMGLAIYDVYVKSKERVLGIYLLFRPAVLIRDADLARRVLAQDFASFHDRGVYVDEERDPL 113
              ..|.|..::          ||..:   |.:::...|..|.:.....|......:::...:..|
Human    83 --TYSQGFTVW----------LGPII---PFIVLCHPDTIRSITNASAAIAPKDNLFIRFLKPWL 132

  Fly   114 SANIFSLRGQSWRSMRHMLSPCFTSGKLKS---MFSTSEDIG-DKMVAHLQKELPEEGFKEVDIK 174
            ...|....|..|...|.||:|.|....|||   :|:.|.:|. ||.     :.|..||...:|:.
Human   133 GEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKW-----QHLASEGSSRLDMF 192

  Fly   175 KVMQNYAIDIIASTIFGLDVNSFENPDNKFRKLVSL-ARANNRFNAMFGMMIFLVPSIAQFLFRI 238
            :.:....:|.:...||..|.:..|.|......::.| |....|...:...|.||     .:|...
Human   193 EHISLMTLDSLQKCIFSFDSHCQERPSEYIATILELSALVEKRSQHILQHMDFL-----YYLSHD 252

  Fly   239 G--FKNPVGL------AMLQIVKETVE-------YREKHGIVRKDLLQLLIQLRNTGKIDENDEK 288
            |  |.....|      |:::..:.|:.       :::|......|.:.:|:
Human   253 GRRFHRACRLVHDFTDAVIRERRRTLPTQGIDDFFKDKAKSKTLDFIDVLL-------------- 303

  Fly   289 SFSIQKTPDGHIKTISLEAITAQAFIFYIAGQETTGSTAAFTIYELAQYPELLKRLQDEVDETLA 353
               :.|..||  |.:|.|.|.|:|..|...|.:||.|..::.:|.||::||..:|.:.||.|.|.
Human   304 ---LSKDEDG--KALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLK 363

  Fly   354 KNDGK-ITYDSLNKMEFLDLCVQETIRKYPGLPILNRECTQDYTVPDTNHVIPKGTPVVISLYGI 417
            ..|.| |.:|.|.::.||.:||:|::|.:|..|.::|.||||..:|| ..|||||...:|.:.|:
Human   364 DRDPKEIEWDDLAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPD-GRVIPKGITCLIDIIGV 427

  Fly   418 HHDAEYFPDPETYDPERFS-EESRNYNPTAFMPFGEGPRICIAQRMGRINSKLAIIKILQNF--- 478
            ||:...:||||.|||.||. |.|:..:|.||:||..|||.||.|.......|:.:..:|.:|
Human   428 HHNPTVWPDPEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFL 492

  Fly   479 --------NVEVMSRSE 487
                    .:|::.|:|
Human   493 PDHTEPRRKLELIMRAE 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d4	NP_651082.1	CYP6-like	66..504	CDD:410679	129/455 (28%)
CYP4F12	NP_076433.3	CYP4F	74..515	CDD:410772	132/482 (27%)