DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6d4 and CYP3A43

DIOPT Version :9

Sequence 1:	NP_651082.1	Gene:	Cyp6d4 / 42682	FlyBaseID:	FBgn0039006	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_073731.1	Gene:	CYP3A43 / 64816	HGNCID:	17450	Length:	504	Species:	Homo sapiens

Alignment Length:	541	Identity:	156/541 - (28%)
Similarity:	272/541 - (50%)	Gaps:	92/541 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLAVTLLTLAWFYLKRHYEYWERRGFPFEKHSGIPF-GC----LDSVWRQEKSMGLAIYDVYVKS 65
            :|..|.|.|.:.|....::.:::.|.|  ..:.:|| |.    |..:|..::.......:::
Human    13 VLVATSLVLLYIYGTHSHKLFKKLGIP--GPTPLPFLGTILFYLRGLWNFDRECNEKYGEMW--- 72

  Fly    66 KERVLGIYLLFRPAVLIRDADLARRVLAQDFASFHDRGVYVDEERDPL-------SANIFSLRGQ 123
                 |:|...:|.::|.|.|:.:.||.::..|     |:.::.  ||       ||..|: ..:
Human    73 -----GLYEGQQPMLVIMDPDMIKTVLVKECYS-----VFTNQM--PLGPMGFLKSALSFA-EDE 124

  Fly   124 SWRSMRHMLSPCFTSGKLKSMFSTSEDIGDKMVAHLQKELPEEGFKEVDIKKVMQNYAIDIIAST 188
            .|:.:|.:|||.|||.|.|.|.......||.:|..|::|  .|..|.:::|.....|.:|:|..|
Human   125 EWKRIRTLLSPAFTSVKFKEMVPIISQCGDMLVRSLRQE--AENSKSINLKDFFGAYTMDVITGT 187

  Fly   189 IFGLDVNSFENPDNKF----RKLVSLARANNRFNAMFGMMIFLVP------------SIAQFLFR 237
            :||::::|..||.:.|    :||:.|... :.|..:..:..||.|            .:..||
Human   188 LFGVNLDSLNNPQDPFLKNMKKLLKLDFL-DPFLLLISLFPFLTPVFEALNIGLFPKDVTHFL-- 249

  Fly   238 IGFKNPVGLAMLQIVKET-VEYREKHGIVRKDLLQLLIQLRNTGKIDENDEKSFSIQKTPDGHIK 301
               ||.:     :.:||: ::.::||   |.|..|.:|..:|:              |....| |
Human   250 ---KNSI-----ERMKESRLKDKQKH---RVDFFQQMIDSQNS--------------KETKSH-K 288

  Fly   302 TISLEAITAQAFIFYIAGQETTGSTAAFTIYELAQYPELLKRLQDEVDETLAKNDGKITYDSLNK 366
            .:|...:.||:.|...|..:||.:|..|.:||||.:|::.::||:|:|..| .|...:|||:|.:
Human   289 ALSDLELVAQSIIIIFAAYDTTSTTLPFIMYELATHPDVQQKLQEEIDAVL-PNKAPVTYDALVQ 352

  Fly   367 MEFLDLCVQETIRKYPGLPILNRECTQDYTVPDTNHV-IPKGTPVVISLYGIHHDAEYFPDPETY 430
            ||:||:.|.||:|.:|.:..:.|.|.:|..:   |.| ||||..|::.:|.:|||.:|:.:||.:
Human   353 MEYLDMVVNETLRLFPVVSRVTRVCKKDIEI---NGVFIPKGLAVMVPIYALHHDPKYWTEPEKF 414

  Fly   431 DPE-RFSEESRN----YNPTAFMPFGEGPRICIAQRMGRINSKLAIIKILQNFNVEVMSRSEIEF 490
            .|| |||:::::    |.   ::|||.|||.||..|....|.|||:|:.||||:.:....::|..
Human   415 CPESRFSKKNKDSIDLYR---YIPFGAGPRNCIGMRFALTNIKLAVIRALQNFSFKPCKETQIPL 476

  Fly   491 ENSGIALI-PKHGVRVRLSKR 510
            :...:.:: |:..:.:::..|
Human   477 KLDNLPILQPEKPIVLKVHLR 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d4	NP_651082.1	p450	58..500	CDD:278495	142/472 (30%)
CYP3A43	NP_073731.1	p450	39..494	CDD:278495	149/510 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.820