Protein Alignment Cyp6d4 and Cyp3a57

DIOPT Version :10

• Sequence 1: NP_651082.1
• Gene: Cyp6d4 / 42682
• FlyBaseID: FBgn0039006
• Length: 515
• Species: Drosophila melanogaster
• Sequence 2: NP_001093650.1
• Gene: Cyp3a57 / 622127
• MGIID: 3646373
• Length: 503
• Species: Mus musculus
• Alignment Length: 509
• Identity: 161/509 - (31%)
• Similarity: 266/509 - (52%)
• Gaps: 74/509 - (14%)

  Fly     6 LLAVTLLTLAWFYLKRHYEY--WERRGFPFEKHSGIP-FG----CLDSVWRQEKSMGLAIYDVYV 63
            :|.||  :|.:||:...|.:  :::.|.|..|  .:| ||    .||.:|:.:.       |.|
Mouse    13 VLLVT--SLVFFYIYGTYSHGLFKKLGIPGPK--PLPLFGNIINYLDGMWKFDD-------DCY- 65

  Fly    64 KSKERVLGIYLLFRPAVLIRDADLARRVLAQDFASFHDRGVYVDEERDP------LSANIFSLRG 122
            |...::.|.|...:|.:.|.|.::.:.||.::..|       |...|.|      |..:|.....
Mouse    66 KKYGKIWGFYEGPQPILAIMDPEIIKIVLVKECYS-------VFTNRRPFGPVGFLKKSITISED 123

  Fly   123 QSWRSMRHMLSPCFTSGKLKSMFSTSEDIGDKMVAHLQKELPEEGFKEVDIKKVMQNYAIDIIAS 187
            :.|:.:|.:|||.|||.|||.||......||.:|.:|::|  ||..:.:::|.:...|::|:|..
Mouse   124 EEWKRLRTLLSPTFTSSKLKEMFPIMRQYGDILVRNLRRE--EEKEEPINMKDIFGAYSMDVITG 186

  Fly   188 TIFGLDVNSFENPDNKF-RKLVSLARANNRFNAMFGMMIFLVPSIAQFLFRIG-----------F 240
            |..|::::|..||.:.| :|:..:.:.  :|...|.:.:.|.|.:......:.           |
Mouse   187 TSCGVNIDSLNNPQDPFVQKIKKILKF--KFFDPFLLSVVLFPFLTPIYEMLNLSIFPRQSMNFF 249

  Fly   241 KNPVGLAMLQIVKETVEYREKHGIVRKDLLQLLIQLRNTGKIDENDEKSFSIQKTPDGHIKTISL 305
            |..|    .::.|:.::|.:|:   |.|.|||::..:|: |..|:              :|.:|.
Mouse   250 KKFV----KKMKKDRLDYNQKN---RVDFLQLMMNTQNS-KGQES--------------LKALSD 292

  Fly   306 EAITAQAFIFYIAGQETTGSTAAFTIYELAQYPELLKRLQDEVDETLAKNDGKITYDSLNKMEFL 370
            ..:.||..||...|.:.|.::.:|.:||||.:|::.|:||||:|..| .|...:|||:|..||:|
Mouse   293 LEMAAQTLIFIFGGYDGTSTSISFIMYELATHPDVQKKLQDEIDRAL-PNKAPVTYDALMDMEYL 356

  Fly   371 DLCVQETIRKYPGLPILNRECTQDYTVPDTNHVIPKGTPVVISLYGIHHDAEYFPDPETYDPERF 435
            |:.|.|::|.||.:..::|...:|..:...  .|||||.|:|.:|.:|.|.||:|:||.:.||||
Mouse   357 DMVVNESLRLYPVVSRIDRFSKKDVEIHGV--FIPKGTIVMIPIYPLHRDPEYWPEPEDFCPERF 419

  Fly   436 SEESR-NYNPTAFMPFGEGPRICIAQRMGRINSKLAIIKILQNFNVEVMSRSEI 488
            |:|:: |.:|..:||||.|||.||..|...|:.|||:..:||||.|:....::|
Mouse   420 SKENKGNIDPYIYMPFGNGPRNCIGMRFALISVKLAVTGVLQNFTVQPCEETQI 473

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d4	NP_651082.1	CYP6-like	66..504	CDD:410679	142/442 (32%)
Cyp3a57	NP_001093650.1	cytochrome_P450	67..492	CDD:477761	142/443 (32%)