Protein Alignment Cyp6d4 and CYP26B1

DIOPT Version :10

• Sequence 1: NP_651082.1
• Gene: Cyp6d4 / 42682
• FlyBaseID: FBgn0039006
• Length: 515
• Species: Drosophila melanogaster
• Sequence 2: NP_063938.1
• Gene: CYP26B1 / 56603
• HGNCID: 20581
• Length: 512
• Species: Homo sapiens
• Alignment Length: 547
• Identity: 123/547 - (22%)
• Similarity: 210/547 - (38%)
• Gaps: 140/547 - (25%)

  Fly     6 LLAVTLLTLAWFYLKRHYEYWERR---------GFPFEKHS-GIPFGCLDSVW----------RQ 50
            |::||||      |....:.|:.|         ..|..|.| |.|.......|          |:
Human    19 LVSVTLL------LAVSQQLWQLRWAATRDKSCKLPIPKGSMGFPLIGETGHWLLQGSGFQSSRR 77

  Fly    51 EKSMGLAIYDVYVKSKERVLGIYLLFRPAVLIRDADLARRVLAQDFASFHDRGVYVDEERDPLSA 115
            ||      |.       .|...:||.||.:.:..|:..|::|   ....|
Human    78 EK------YG-------NVFKTHLLGRPLIRVTGAENVRKIL---MGEHH--------------- 111

  Fly   116 NIFSLRGQSW-RSMRHMLSPCFTSGKLKSMFSTSEDIGDKMVAH--LQKELPEEGFKEVDIKKVM 177
                |....| ||.|.:|.|...|..:..:......:..|:.:|  |:..||:       |:.|:
Human   112 ----LVSTEWPRSTRMLLGPNTVSNSIGDIHRNKRKVFSKIFSHEALESYLPK-------IQLVI 165

  Fly   178 QN---------YAIDIIAST---IFGLDVN---SFENPDNKFRKLVSLARANNRFNAMFGMMIFL 227
            |:         .||::....   .|.:.:.   .|..|:.....|..:.:       .|...:|.
Human   166 QDTLRAWSSHPEAINVYQEAQKLTFRMAIRVLLGFSIPEEDLGHLFEVYQ-------QFVDNVFS 223

  Fly   228 VPSIAQFLFRIGFKNPVGLAMLQIVKETVE--YREK----HGIVRKDLLQLLIQLRNTGKIDEND 286
            :|....|   .|::.  |:...||:::.:|  .|||    .|....|.|.|||:      ..:..
Human   224 LPVDLPF---SGYRR--GIQARQILQKGLEKAIREKLQCTQGKDYLDALDLLIE------SSKEH 277

  Fly   287 EKSFSIQKTPDGHIKTISLEAITAQAFIFYIAGQETTGSTAAFTIYELAQYPELLKRLQDE---- 347
            .|..::|:..||.::.|             .|...||.|.:...|.:|.::|.:|::|:||
Human   278 GKEMTMQELKDGTLELI-------------FAAYATTASASTSLIMQLLKHPTVLEKLRDELRAH 329

  Fly   348 --VDETLAKNDGKITYDSLNKMEFLDLCVQETIRKYPGLPILNRECTQDYTVPDTNHVIPKGTPV 410
              :.......:|.:..|:|:.:.:||..::|.:|.:  .||.....|...|.......||||..|
Human   330 GILHSGGCPCEGTLRLDTLSGLRYLDCVIKEVMRLF--TPISGGYRTVLQTFELDGFQIPKGWSV 392

  Fly   411 VISLYGIHHDAEYFPDPETYDPERFSEESRNYNPTA---FMPFGEGPRICIAQRMGRINSKLAII 472
            :.|:...|..|..|.|...:||:||| ::|:.:...   ::|||.|.|.|:.:.:.::..|:..:
Human   393 MYSIRDTHDTAPVFKDVNVFDPDRFS-QARSEDKDGRFHYLPFGGGVRTCLGKHLAKLFLKVLAV 456

  Fly   473 KILQNFNVEVMSRSEIEFENSGIALIP 499
            ::......|:.:|:   |..  |.|:|
Human   457 ELASTSRFELATRT---FPR--ITLVP 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d4	NP_651082.1	CYP6-like	66..504	CDD:410679	105/467 (22%)
CYP26B1	NP_063938.1	CYP26B1	60..490	CDD:410730	110/500 (22%)