Protein Alignment Cyp6d4 and Cyp3a25

DIOPT Version :10

• Sequence 1: NP_651082.1
• Gene: Cyp6d4 / 42682
• FlyBaseID: FBgn0039006
• Length: 515
• Species: Drosophila melanogaster
• Sequence 2: NP_062766.2
• Gene: Cyp3a25 / 56388
• MGIID: 1930638
• Length: 503
• Species: Mus musculus
• Alignment Length: 514
• Identity: 163/514 - (31%)
• Similarity: 262/514 - (50%)
• Gaps: 74/514 - (14%)

  Fly     6 LLAVTLLTLAWFYLKRHYEYWERRGFPFEKH---SGIPFGCLDSVWRQEKSMGLAIYDVYVKSKE 67
            :|.||.|.|.:.|....:..:::.|.|..|.   .|..|...|.:|:.::       |.| |...
Mouse    13 VLLVTSLVLFYIYGTYSHGLFKKLGIPGPKPLPLLGTIFNYYDGMWKFDE-------DCY-KKYG 69

  Fly    68 RVLGIYLLFRPAVLIRDADLARRVLAQDFAS------------FHDRGVYVDEERDPLSANIFSL 120
            ::.|.|...:|.:.|.|.::.:.||.::..|            |..:.:.:.|:
Mouse    70 KIWGFYEGPQPILAIMDPEIIKIVLVKECYSVFTNRRFFGPVGFMKKAITISED----------- 123

  Fly   121 RGQSWRSMRHMLSPCFTSGKLKSMFSTSEDIGDKMVAHLQKELPEEGFKEVDIKKVMQNYAIDII 185
              :.|:.:|.:|||.|||||||.||......||.:|.:|::|  ||..:.:.:|.:...|::|:|
Mouse   124 --EEWKRLRTLLSPTFTSGKLKEMFPIMRQYGDILVRNLRRE--EEKGEPISMKDIFGAYSMDVI 184

  Fly   186 ASTIFGLDVNSFENPDNKFRKLVSLARANNRFNAM--FGMMIFLVPSIAQFLFRIGFK------- 241
            ..|.||::|:|..||.:.|   |..|:...:|...  |.:.|.|.|.:......:.|.
Mouse   185 TGTSFGVNVDSLNNPQDPF---VQKAKKILKFKIFDPFLLSIILFPFLTPIYEMLNFSIFPRDSM 246

  Fly   242 NPVGLAMLQIVKETVEYREKHGIVRKDLLQLLIQLRNTGKIDENDEKSFSIQKTPDGHIKTISLE 306
            |.....:.::.||.:...:|:   |.|.|||::..:|:.  .:..:|:.|            .||
Mouse   247 NFFKKFVKRMKKERLASNQKN---RVDFLQLMMNTQNSK--GQESQKALS------------DLE 294

  Fly   307 AITAQAFIFYIAGQETTGSTAAFTIYELAQYPELLKRLQDEVDETLAKNDGKITYDSLNKMEFLD 371
             :.|||.||...|.:.|.::.:..:||||.:|::.|:||||:|.|| .|...:|||:|..||:||
Mouse   295 -MAAQAVIFIFGGYDATSTSISLIMYELATHPDVQKKLQDEIDRTL-PNKAPVTYDALMDMEYLD 357

  Fly   372 LCVQETIRKYPGLPILNRECTQDYTVPDTNHV-IPKGTPVVISLYGIHHDAEYFPDPETYDPERF 435
            :.|.|::|.||....|.|...:|..:   |.| |||||.|:|.:|.:|.:.||:|:|:.:.||||
Mouse   358 MVVNESLRLYPIAIRLERVSKKDVEI---NGVFIPKGTVVMIPIYPLHRNPEYWPEPQEFCPERF 419

  Fly   436 SEESR-NYNPTAFMPFGEGPRICIAQRMGRINSKLAIIKILQNFNVEVMSRSEIEFENS 493
            |:|:: |.:|..:||||.|||.||..|...|:.|||:|.:||||.|:....::|..:.|
Mouse   420 SKENKGNIDPYIYMPFGNGPRNCIGMRFALISIKLAVIGVLQNFTVQPCEETQIPLKIS 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d4	NP_651082.1	CYP6-like	66..504	CDD:410679	147/451 (33%)
Cyp3a25	NP_062766.2	CYP3A	67..492	CDD:410743	147/452 (33%)