DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6d4 and cyp3c4

DIOPT Version :9

Sequence 1:	NP_651082.1	Gene:	Cyp6d4 / 42682	FlyBaseID:	FBgn0039006	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_001071016.1	Gene:	cyp3c4 / 558541	ZFINID:	ZDB-GENE-060929-96	Length:	507	Species:	Danio rerio

Alignment Length:	530	Identity:	164/530 - (30%)
Similarity:	274/530 - (51%)	Gaps:	60/530 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FSLILLAVTLLTLAWFYLKRHYEYWERRGFPFEKHSGIP-------FGCLDSVWRQEKSMGLAIY 59
            ::|::|.:|||.:        |..|..|   |....|||       .|.|.|.     :.||..:
Zfish    11 WTLVVLVITLLFI--------YGVWPHR---FFIKLGIPGPRPWPFVGTLLSY-----AKGLCNF 59

  Fly    60 DV-YVKSKERVLGIYLLFRPAVLIRDADLARRVLAQD-FASFHDRGVYVDEERDPLSANIFSLRG 122
            |: ..|...:|.|||....|.:::.|.::.:.||.:: :::|.:|.........|.|..|..::.
Zfish    60 DMECAKKYGKVWGIYDGRLPILMVADLEVIKVVLVKECYSNFINRRKRTTGLAGPFSDGIIMVKD 124

  Fly   123 QSWRSMRHMLSPCFTSGKLKSMFSTSEDIGDKMVAHLQKELPEEGFKEVDIKKVMQNYAIDIIAS 187
            :.|:.||..|||.||||:||.:|..:....|:.:.::||:.||:   .|.||:|:..|::|:|.|
Zfish   125 ERWKRMRSTLSPYFTSGRLKEIFPIAMTHADRFIKNMQKKDPEQ---PVKIKEVVAPYSLDVITS 186

  Fly   188 TIFGLDVNSFENPDNKF----RKLVSLARANNRFNAMFGMMIFLVPSIAQFLFRIG---FKNPVG 245
            :.|.:|::|..||::.|    :|.:..    |.||.:. ::|.|.||:|..|.::|   |.....
Zfish   187 SSFSVDIDSINNPEDPFVINVKKFIQF----NMFNPLL-LLILLFPSLAIPLKKMGVTLFSKSAM 246

  Fly   246 LAMLQIVKETVEYREKHGIVRKDLLQLLIQLR-NTGKIDENDEKSFSIQKTPDGHIKTISLEAIT 309
            .....::|:..:...|....|.|.|:|::|.: ...:|.::|        |.:...|.::...|.
Zfish   247 DFFYSVLKKIKDDHNKESEGRVDFLKLMLQNQIPDDQIQDSD--------TSEQPAKGLTDHEIL 303

  Fly   310 AQAFIFYIAGQETTGSTAAFTIYELAQYPELLKRLQDEVDETLAKN---DGKITYDSLNKMEFLD 371
            :|:.:|.:.|.|||.:|..|.:|.||..|:.|::|.:|:|    ||   |..||||:|.:|::|:
Zfish   304 SQSLVFILGGYETTSTTLTFLLYNLATNPDCLEKLVEEID----KNFPLDTPITYDALMRMDYLE 364

  Fly   372 LCVQETIRKYPGLPILNRECTQDYTVPDTNHVIPKGTPVVISLYGIHHDAEYFPDPETYDPERFS 436
            :.:.|::|..|..|.|.|...:  ||......||:||.|.|..|.:.||.:.:..|..:.|||||
Zfish   365 MAINESMRLLPTAPRLERSAKK--TVVINGLTIPEGTLVGIPTYVLSHDPDIWESPGEFRPERFS 427

  Fly   437 EESRN-YNPTAFMPFGEGPRICIAQRMGRINSKLAIIKILQNFNVEVMSRSEIEFENSGIALIPK 500
            .|::: :...||:|||.|||.||..|...:..||.::|:||||:||....::|..| ..:...||
Zfish   428 PENKSEFLQYAFIPFGLGPRNCIGMRYAVMIMKLFVVKLLQNFSVETCKETQIPLE-MNVTFQPK 491

  Fly   501 HGVRVRLSKR 510
            ..:.::|..|
Zfish   492 VPITLKLIPR 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d4	NP_651082.1	p450	58..500	CDD:278495	143/455 (31%)
cyp3c4	NP_001071016.1	p450	38..485	CDD:278495	149/474 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	226	1.000	Domainoid score	I2453
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8426
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.820