DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6d4 and cyp3c2

DIOPT Version :9

Sequence 1:	NP_651082.1	Gene:	Cyp6d4 / 42682	FlyBaseID:	FBgn0039006	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	XP_021330384.1	Gene:	cyp3c2 / 558473	ZFINID:	ZDB-GENE-081103-62	Length:	503	Species:	Danio rerio

Alignment Length:	545	Identity:	168/545 - (30%)
Similarity:	281/545 - (51%)	Gaps:	81/545 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFSLILLAVT----LLTLAWFYLKRHYEYWERRGFPFEKHSGIP-------FGCLDSVWRQEKSM 54
            |..|..|:||    :|.|...|:   |..|..   .|.|..|||       ||...|.     :.
Zfish     1 MIDLSSLSVTWILVVLVLTLLYM---YGVWPH---GFFKKLGIPGPRPWPFFGTFLSY-----TK 54

  Fly    55 GLAIYDV-YVKSKERVLGIYLLFRPAVLIRDADLARRVLAQD-FASFHDRGVYVDEERDPLSANI 117
            |...:|: ..|...:|.|||....|.:::.|.::.:.::.:: :::|.:|.....:...||:..|
Zfish    55 GFFNFDMECAKKYGKVWGIYDGRLPILMVTDLEMIKTIMVKECYSTFTNRREINVDLAGPLADGI 119

  Fly   118 FSLRGQSWRSMRHMLSPCFTSGKLKSMFSTSEDIGDKMVAHLQKELPEEGFKEVDIKKVMQNYAI 182
            .:::.:.|:.:|..|||.||||:||.:|..:....|:.:.::||...|:   .|.||:||.:|::
Zfish   120 TAVKDERWKRIRGTLSPYFTSGRLKEIFPIAMTHADRFIKNMQKGDHEQ---PVKIKEVMASYSL 181

  Fly   183 DIIASTIFGLDVNSFENPDNKFRKLVSLARANNRFNAMFGMMIFLV---PSIAQFLFRIG---FK 241
            |::.|:.|.:|::|..|||:.|   |:..:...:|| :||:.:.|:   ||||..|.::|   |.
Zfish   182 DVVTSSAFSVDIDSINNPDDPF---VTNIKNFLKFN-LFGLFVLLLTVFPSIANLLGKMGLSMFS 242

  Fly   242 NPV---GLAMLQIVKETVEYREKHGIVRKDLLQLLIQLRNTGKIDENDEKSFSIQKTPDGHIKTI 303
            .|.   ....|:.:||  |:::.:|  |.|..:|:||                 .:.||..:|..
Zfish   243 KPTVDFFYKALRKIKE--EHKDSNG--RVDFFRLMIQ-----------------NEIPDDQVKDT 286

  Fly   304 SLE---------AITAQAFIFYIAGQETTGSTAAFTIYELAQYPELLKRLQDEVDETLAKN---D 356
            :.|         .|.:|:|||.:.|.|||.:|..|.:|.||..|:.|::|.:::|    ||   |
Zfish   287 TSEQPEKGLTDHEILSQSFIFIMGGYETTSTTLTFLLYNLAINPDCLEKLVEKID----KNFPLD 347

  Fly   357 GKITYDSLNKMEFLDLCVQETIRKYPGLPILNRECTQDYTVPDTNHVIPKGTPVVISLYGIHHDA 421
            ..|:||:|.|:::|::.:.|::|..|..|.|.|.|.:  ||......|||.|.:.|..|.::.|.
Zfish   348 TPISYDALMKIDYLEMSINESMRLLPTAPRLERVCKK--TVEMNGITIPKDTMITIPTYVLNQDP 410

  Fly   422 EYFPDPETYDPERFSEESRN-YNPTAFMPFGEGPRICIAQRMGRINSKLAIIKILQNFNVEVMSR 485
            :.:..|..:.|||||.|::: :...||||||.|||.||..|...:..||.::|:||||:||....
Zfish   411 QLWDSPHEFRPERFSPENKSEFLQYAFMPFGLGPRNCIGMRYALMIVKLLVVKLLQNFSVETCKE 475

  Fly   486 SEIEFENSGIALIPKHGVRVRLSKR 510
            ::|..|.:.: ..||..:.::|:.|
Zfish   476 TQIPLELNPV-FQPKVPITLKLTPR 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d4	NP_651082.1	p450	58..500	CDD:278495	145/465 (31%)
cyp3c2	XP_021330384.1	p450	38..496	CDD:306555	152/497 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910