Protein Alignment Cyp6d4 and CYP4F3

DIOPT Version :10

• Sequence 1: NP_651082.1
• Gene: Cyp6d4 / 42682
• FlyBaseID: FBgn0039006
• Length: 515
• Species: Drosophila melanogaster
• Sequence 2: NP_000887.2
• Gene: CYP4F3 / 4051
• HGNCID: 2646
• Length: 520
• Species: Homo sapiens
• Alignment Length: 533
• Identity: 146/533 - (27%)
• Similarity: 232/533 - (43%)
• Gaps: 94/533 - (17%)

  Fly     4 LILLAVTLL---TLAWFYLKRHYEYWER-RGFP-------FEKHSGI----------------PF 41
            |:|:..:.|   .|||.|  ..|:...| |.||       |..|.|:                .|
Human    22 LLLVGASWLLARILAWTY--TFYDNCCRLRCFPQPPKRNWFLGHLGLIHSSEEGLLYTQSLACTF 84

  Fly    42 GCLDSVWRQEKSMGLAIY-DVYVKSKERVLGIYLLFRPAVLI-RDADLARRVLAQDFASFHDRGV 104
            |.:...|.......:.|: ..|:|.        :||.||.:: :|         :.|.||
Human    85 GDMCCWWVGPWHAIVRIFHPTYIKP--------VLFAPAAIVPKD---------KVFYSF----- 127

  Fly   105 YVDEERDPLSANIFSLRGQSWRSMRHMLSPCFTSGKLK---SMFSTSEDIGDKMVAHLQKELPEE 166
                .:..|...:....|:.|...|.||:|.|....||   .:|:.|.:|   |.|..|. |..|
Human   128 ----LKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNI---MHAKWQL-LASE 184

  Fly   167 GFKEVDIKKVMQNYAIDIIASTIFGLDVNSFENPDNKFRKLVSLA----RANNRFNAMFGMMIFL 227
            |...:|:.:.:....:|.:...:|..|.:..|.|......::.|:    :.:.:.......:.:|
Human   185 GSARLDMFEHISLMTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVTKRHQQILLYIDFLYYL 249

  Fly   228 VPSIAQFLFRIGFKNPVGLAMLQIVKETVEYREKHGIVRKDLLQLLIQLRNTGKIDENDEKSFSI 292
            .|...:|.......:....|::|..:.|:   ...|:  .|.||...:.:....||     ...:
Human   250 TPDGQRFRRACRLVHDFTDAVIQERRRTL---PSQGV--DDFLQAKAKSKTLDFID-----VLLL 304

  Fly   293 QKTPDGHIKTISLEAITAQAFIFYIAGQETTGSTAAFTIYELAQYPELLKRLQDEVDETLAKNDG 357
            .|..||  |.:|.|.|.|:|..|...|.:||.|..::.:|.||::||..:|.:.||.|.|...:.
Human   305 SKDEDG--KKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREP 367

  Fly   358 K-ITYDSLNKMEFLDLCVQETIRKYPGLPILNRECTQDYTVPDTNHVIPKGTPVVISLYGIHHDA 421
            | |.:|.|.::.||.:|::|::|.:|.:|.::|.||||..:|| ..|||||...:||::|.||:.
Human   368 KEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPD-GRVIPKGIICLISVFGTHHNP 431

  Fly   422 EYFPDPETYDPERFSEES-RNYNPTAFMPFGEGPRICIAQRMGRINSKLAIIKILQNFNV----- 480
            ..:||||.|||.||..:: :..:|.||:||..|||.||.|.......|:.:...|..|.|
Human   432 AVWPDPEVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLRFRVLPDHT 496

  Fly   481 ------EVMSRSE 487
                  |::.|:|
Human   497 EPRRKPELVLRAE 509

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d4	NP_651082.1	CYP6-like	66..504	CDD:410679	125/443 (28%)
CYP4F3	NP_000887.2	CYP4F	74..515	CDD:410772	131/479 (27%)