DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6d4 and Cyp6d2

DIOPT Version :9

Sequence 1:	NP_651082.1	Gene:	Cyp6d4 / 42682	FlyBaseID:	FBgn0039006	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_611698.1	Gene:	Cyp6d2 / 37594	FlyBaseID:	FBgn0034756	Length:	512	Species:	Drosophila melanogaster

Alignment Length:	512	Identity:	257/512 - (50%)
Similarity:	381/512 - (74%)	Gaps:	10/512 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ILLAVTLLTLAWFYLKRHYEYWERRGFPFEKHSGIPFGCLDSVWRQEKSMGLAIYDVYVKSKERV 69
            |||.:.:..|.:.|:||||.:|:|.|.. |:.:.||||.:|:|.:||:|:|:|:.|:|.:.:.::
  Fly     4 ILLTILIAGLLYRYVKRHYTHWQRLGVD-EEPAKIPFGVMDTVMKQERSLGMALADIYARHEGKI 67

  Fly    70 LGIYLLFRPAVLIRDADLARRVLAQDFASFHDRGVYVDEERDPLSANIFSLRGQSWRSMRHMLSP 134
            :|||:|.:.::|||||.|||:::..||||||||||||||::||||||:|:|||.|||::|..|:|
  Fly    68 VGIYMLNKRSILIRDAQLARQIMTSDFASFHDRGVYVDEDKDPLSANLFNLRGASWRNLRQKLTP 132

  Fly   135 CFTSGKLKSMFSTSEDIGDKMVAHLQKELPEEGFKEVDIKKVMQNYAIDIIASTIFGLDVNSFEN 199
            .|:|||:|.||.|.:|:|||:|.||:..|.:.  .||:||.||..||:|||.|.||||:::||.|
  Fly   133 SFSSGKIKGMFGTIDDVGDKLVQHLEGALDQS--DEVEIKDVMTTYAVDIIGSVIFGLEIDSFRN 195

  Fly   200 PDNKFRKL-VSLARANNRFNAMFGMMIFLVPSIAQFLFRIGFKNPVGLAMLQIVKETVEYREKHG 263
            |.|:||:: .|.:|..:....:..|.:|:.|.||:.:.|:|:::.:..::..::|.|:|:||:|.
  Fly   196 PKNEFREISSSTSRDESLLLKIHNMSMFICPPIAKLMNRLGYESRILTSLRDMMKRTIEFREEHN 260

  Fly   264 IVRKDLLQLLIQLRNTGKIDENDEKSFSIQKTPDGHIKTISLEAITAQAFIFYIAGQETTGSTAA 328
            :||||:|||||:|||||||.|:|::.:.:: |....:|::|:|.|.||||:||:||.|:|.:.:|
  Fly   261 VVRKDMLQLLIRLRNTGKIGEDDDQVWDME-TAQEQLKSMSIEKIAAQAFLFYVAGSESTAAASA 324

  Fly   329 FTIYELAQYPELLKRLQDEVDETLAKND----GKITYDSLNKMEFLDLCVQETIRKYPGLPILNR 389
            ||:|||:.||||||..|:|||..|.|::    .:.||:::..::|||:|:.||||||||||.|||
  Fly   325 FTLYELSMYPELLKEAQEEVDAVLMKHNLKPKDRFTYEAVQDLKFLDICIMETIRKYPGLPFLNR 389

  Fly   390 ECTQDYTVPDTNHVIPKGTPVVISLYGIHHDAEYFPDPETYDPERFSEESRNYNPTAFMPFGEGP 454
            |||:||.||.|||:|.||||::|||:|:..|..|||:|..|||.||...:.||:..|:|||||||
  Fly   390 ECTEDYPVPGTNHIIAKGTPILISLFGMQRDPVYFPNPNGYDPHRFDSNNMNYDQAAYMPFGEGP 454

  Fly   455 RICIAQRMGRINSKLAIIKILQNFNVEVMSRSEIEFE-NSGIALIPKHGVRVRLSKR 510
            |.|||.|||::|||:|:.|||.||::....|.|:||. ::...|:.|..:::||:||
  Fly   455 RHCIALRMGKVNSKVAVAKILANFDLVQSPRKEVEFRFDAAPVLVTKEPLKLRLTKR 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d4	NP_651082.1	p450	58..500	CDD:278495	228/447 (51%)
Cyp6d2	NP_611698.1	p450	65..506	CDD:278495	227/443 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469014
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	1	1.000	-	-		H114273
Inparanoid	1	1.050	156	1.000	Inparanoid score	I1665
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26097
OrthoDB	1	1.010	-	-		D25005at7147
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8426
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	12	11.910