DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6d4 and Cyp6a9

DIOPT Version :9

Sequence 1:	NP_651082.1	Gene:	Cyp6d4 / 42682	FlyBaseID:	FBgn0039006	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_523748.2	Gene:	Cyp6a9 / 36663	FlyBaseID:	FBgn0013771	Length:	504	Species:	Drosophila melanogaster

Alignment Length:	494	Identity:	165/494 - (33%)
Similarity:	268/494 - (54%)	Gaps:	29/494 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ILLAVTLLTLAWFYLK--RHYEYWERRGFPFEK-HSGIPFGCLDSVWRQEKSMGLAIYDVYVKSK 66
            :|||:.::.:.:..||  |...||:....|.|: |  |..|.|..| :..:|......|.|.|.:
  Fly     6 VLLAIVVVLVGYLLLKWRRALHYWQNLDIPCEEPH--ILMGSLTGV-QTSRSFSAIWMDYYNKFR 67

  Fly    67 ER--VLGIYLLFRPAVLIRDADLARRVLAQDFASFHDRGVYVDEERDPLSANIFSLRGQSWRSMR 129
            ..  ..|.|...||.:|:.|..||:.:|.::|..|.|||.|.:.|.||||..:|.|.||.|:|||
  Fly    68 GTGPFAGFYWFQRPGILVLDISLAKLILIKEFNKFTDRGFYHNTEDDPLSGQLFLLDGQKWKSMR 132

  Fly   130 HMLSPCFTSGKLKSMFSTSEDIGDKMVAHLQKELPEEGFKEVDIKKVMQNYAIDIIASTIFGLDV 194
            ..||..|||||:|.||.|...:|.:.:....:.:.:...  |:::.::..:..|:|.:..||::.
  Fly   133 SKLSYTFTSGKMKYMFPTVVKVGHEFIEVFGQAMEKSPI--VEVRDILARFTTDVIGTCAFGIEC 195

  Fly   195 NSFENPDNKFRKLVSLARANNRFNAMFGMMIFLVPSIAQFLFRIGFKNPVGLA---MLQIVKETV 256
            :|.::|:.:||.:...|....|...   :.|..:.|......|:..|..:..|   .|:||:|||
  Fly   196 SSLKDPEAEFRVMGRRAIFEQRHGP---IGIAFINSFQNLARRLHMKITLEEAEHFFLRIVRETV 257

  Fly   257 EYREKHGIVRKDLLQLLIQLRNTGKIDENDEKSFSIQKTPDGHIKTISLEAITAQAFIFYIAGQE 321
            .:|||:.|.|.|.:..||.|:|:           .:.|:..|....:::|.:.||||:|:.||.|
  Fly   258 AFREKNNIRRNDFMDQLIDLKNS-----------PLTKSESGESVNLTIEEMAAQAFVFFGAGFE 311

  Fly   322 TTGSTAAFTIYELAQYPELLKRLQDEVDETLAKNDGKITYDSLNKMEFLDLCVQETIRKYPGLPI 386
            |:.:|..|.:|||||:.::..|::.|..|.:.|.:|:|||:|:..|.:||..:.||:|.|..||:
  Fly   312 TSSTTMGFALYELAQHQDIQDRVRKECQEVIGKYNGEITYESMKDMVYLDQVISETLRLYTVLPV 376

  Fly   387 LNRECTQDYTVP-DTNHVIPKGTPVVISLYGIHHDAEYFPDPETYDPERFS-EESRNYNPTAFMP 449
            |||||.:||.|| ...:||.||.||:|....:|.|.:.:.:|.|::|:.|| |..:..:...::|
  Fly   377 LNRECLEDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNFSPERVKERDSVEWLP 441

  Fly   450 FGEGPRICIAQRMGRINSKLAIIKILQNFNVEVMSRSEI 488
            ||:|||.||..|.|::.::..:..::..|...|..::.|
  Fly   442 FGDGPRNCIGMRFGQMQARSGLALLINRFKFSVCEQTTI 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d4	NP_651082.1	p450	58..500	CDD:278495	149/438 (34%)
Cyp6a9	NP_523748.2	p450	35..499	CDD:278495	157/465 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461184
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3345
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	10	9.900