DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6d4 and Cyp6t3

DIOPT Version :9

Sequence 1:	NP_651082.1	Gene:	Cyp6d4 / 42682	FlyBaseID:	FBgn0039006	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_610745.1	Gene:	Cyp6t3 / 36318	FlyBaseID:	FBgn0033697	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	524	Identity:	144/524 - (27%)
Similarity:	254/524 - (48%)	Gaps:	41/524 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFSLILLAVTLLTLAWFYLKRHYEYWERRGFP-FEKHSGIPFGCLDSVWRQEKSMGLAIYDVYV- 63
            |..:.||.:|::||. |:|:..|:|:..||.| ....|..|.|.|..:.....|.|.....:|.
  Fly     1 MLLIWLLLLTIVTLN-FWLRHKYDYFRSRGIPHLPPSSWSPMGNLGQLLFLRISFGDLFRQLYAD 64

  Fly    64 --KSKERVLGIYLLFRPAVLIRDADLARRVLAQDFASFHDRGVYVDEERDPLSANIFSL-RGQSW 125
              ..:.:::|.::...||:::||.:|.|:||.::|.:|.:|....| ..||:.|....| :...|
  Fly    65 PRNGQAKIVGFFIFQTPALMVRDPELIRQVLIKNFNNFLNRFESAD-AGDPMGALTLPLAKYHHW 128

  Fly   126 RSMRHMLSPCFTSGKLKS-MFSTSEDIGDKMVAHLQKELPEEGFKEVDIKKVMQNYAIDIIASTI 189
            :..|..:|..||||:::. |:|...|:...:..:|.::|.:...:.:.:.::.|.|..|:..:..
  Fly   129 KESRQCMSQLFTSGRMRDVMYSQMLDVASDLEQYLNRKLGDRLERVLPLGRMCQLYTTDVTGNLF 193

  Fly   190 FGLDVNSFENPDNK-FRKLVSLARANNRFNAMFGMMIFLVPSIAQFLFRIGFKNPVGLAMLQIVK 253
            :.|:|.......:: ..|...|...|.| ..:..|.:|.:|.....|....|.......|..:|.
  Fly   194 YSLNVGGLRRGRSELITKTKELFNTNPR-KVLDFMSVFFLPKWTGVLKPKVFTEDYARYMRHLVD 257

  Fly   254 ETVEYREKHGIVRKDLLQLLIQLRNTGKIDENDEKSFSIQKTPDGHIKTISLEAITAQAFIFYIA 318
                  :.|...:.||:              |..:.|.:.::.:.:.:  ..:.:.:||.|..:|
  Fly   258 ------DHHEPTKGDLI--------------NQLQHFQLSRSSNHYSQ--HPDFVASQAGIILLA 300

  Fly   319 GQETTGSTAAFTIYELAQYPELLKRLQDEVDETLAKNDGKITYDSLNKMEFLDLCVQETIRKYPG 383
            |.||:.:...||:||||:.|::.:||:.|:.|... :...::||:|..:.:|.:...|.:|.||.
  Fly   301 GFETSSALMGFTLYELAKAPDIQERLRSELREAFI-STATLSYDTLMTLPYLKMVCLEALRLYPA 364

  Fly   384 LPILNRECTQDYT-----VPDTNHVIPKGTPVVISLYGIHHDAEYFPDPETYDPERFS-EESRNY 442
            ...:|||||...:     .|..:.::|.|.|..||:.|:|.|..::|:|..:|||||. |.||:.
  Fly   365 AAFVNRECTSSASEGFSLQPHVDFIVPPGMPAYISILGLHRDERFWPEPCVFDPERFGPERSRHI 429

  Fly   443 NPTAFMPFGEGPRICIAQRMGRINSKLAIIKILQNFNVEVMSR--SEIEFENSGIALIPKHGVRV 505
            :|..::|||.||..||..|:|.:..||.|:.||:.:.||...|  |||.|......|..::.:.:
  Fly   430 HPMTYIPFGAGPHGCIGSRLGVLQLKLGIVHILKQYWVETCERTVSEIRFNPKSFMLESENEIYL 494

  Fly   506 RLSK 509
            |..:
  Fly   495 RFCR 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d4	NP_651082.1	p450	58..500	CDD:278495	124/455 (27%)
Cyp6t3	NP_610745.1	p450	34..486	CDD:299894	129/476 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461009
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1773
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	10	9.900