DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6d4 and Cyp9b2

DIOPT Version :9

Sequence 1:	NP_651082.1	Gene:	Cyp6d4 / 42682	FlyBaseID:	FBgn0039006	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_523646.1	Gene:	Cyp9b2 / 35635	FlyBaseID:	FBgn0015039	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	529	Identity:	161/529 - (30%)
Similarity:	276/529 - (52%)	Gaps:	47/529 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SLILLAVTLLTLAWFYLK---RHYEYWERRGFPFEKHSGIPF-GCLDSVWRQEKSMGLAIYDVYV 63
            :||.:.:.|:.:.:...|   ..::.:|.|...|||  ..|| |.:.:...|:.|....:.:.|.
  Fly     2 ALIEICLALVVIGYLIYKWSTATFKTFEERKLYFEK--PYPFVGNMAAAALQKSSFQRQLTEFYE 64

  Fly    64 KSKE-RVLGIYLLFRPAVLIRDADLARRVLAQDFASFHDRGVYVDEERDPLSANIFS-LRGQSWR 126
            :::: :::|.:.:..|.:.:.|.:|.::|..:||..|.:...:: ...|.|..::.| :|.|.|:
  Fly    65 RTRQHKLVGFFNMRTPMITLNDPELIKKVCVKDFDHFPNHQPFI-TSNDRLFNDMLSVMRDQRWK 128

  Fly   127 SMRHMLSPCFTSGKLKSMFSTSEDIGDKMVAHL---QKELP-EEGFKEVDIKKVMQNYAIDIIAS 187
            .||:.|:|.||:.|:::||:...:...:.:.||   .|.|| .:|| |||:|.:....:.||||:
  Fly   129 HMRNTLTPVFTAAKMRNMFTLMNESFAECLQHLDSSSKTLPGRKGF-EVDMKVMCNKLSNDIIAT 192

  Fly   188 TIFGLDVNSFENPDNKFRKL---VSLARANNRFNAMFGMMIFLVPSIAQFLFRIGFKNPVGLAML 249
            |.|||.|||::||.|:|.::   :..:|....|..|...   |||.:...|....|.:.......
  Fly   193 TAFGLKVNSYDNPKNEFYEIGQSLVFSRGLQFFKFMLST---LVPKLFSLLKLTIFDSAKVDYFA 254

  Fly   250 QIVKETVEYREKHGIVRKDLLQLLIQLRNTGKIDENDEKSFSIQKTPDGHIKTISLEAITAQAFI 314
            ::|.|.::|||||.|.|.|::|||::.:|     |:::|     .|.|         .|.||.||
  Fly   255 RLVVEAMQYREKHNITRPDMIQLLMEAKN-----ESEDK-----WTDD---------EIVAQCFI 300

  Fly   315 FYIAGQETTGSTAAFTIYELAQYPELLKRLQDEVDET-LAKNDGKITYDSLNKMEFLDLCVQETI 378
            |:.|..|...:....|.|||...|::.:||.:|:.|| .|.|...:|||::.||.::|:.:.|::
  Fly   301 FFFAAFENNSNLICTTTYELLYNPDVQERLYEEIVETKKALNGAPLTYDAVQKMTYMDMVISESL 365

  Fly   379 RKYPGLPILNRECTQDYTVPDTNHV----IPKGTPVVISLYGIHHDAEYFPDPETYDPERFSEES 439
            ||:......:|.|::|||:.|.:..    ...|..:.|.:.|:|.|..|||:|..:||:|||||.
  Fly   366 RKWTLAAATDRLCSKDYTLTDDDGTKLFDFKVGDRINIPISGLHLDDRYFPEPRKFDPDRFSEER 430

  Fly   440 R-NYNPTAFMPFGEGPRICIAQRMGRINSKLAIIKILQNFNVEVMSRS--EIEFENSGIALIPKH 501
            : :..|..::|||.|||.||..|...:..|..:..:|.::.:|...|:  ::....||....|:.
  Fly   431 KGDMVPYTYLPFGVGPRNCIGNRYALMQVKGMLFNLLLHYKIEASPRTIKDLWGSASGFNFTPRS 495

  Fly   502 GVRVRLSKR 510
            |..:.|..|
  Fly   496 GFWMHLVPR 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d4	NP_651082.1	p450	58..500	CDD:278495	143/458 (31%)
Cyp9b2	NP_523646.1	p450	37..478	CDD:299894	146/466 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461151
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	274	1.000	Inparanoid score	I2893
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	10	9.900