DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6d4 and Cyp6w1

DIOPT Version :9

Sequence 1:	NP_651082.1	Gene:	Cyp6d4 / 42682	FlyBaseID:	FBgn0039006	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_001286145.1	Gene:	Cyp6w1 / 35543	FlyBaseID:	FBgn0033065	Length:	514	Species:	Drosophila melanogaster

Alignment Length:	542	Identity:	170/542 - (31%)
Similarity:	275/542 - (50%)	Gaps:	75/542 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LILLAVTLLTLAWFYL--KRHYEYWERRGFPFEKHSGIPF---GCLDSVWRQEKSMGLAIYDVYV 63
            |:||.:..||:. ||:  :|...:|||.|..:.:    ||   ||.    |:..:..:..::...
  Fly     2 LLLLLLGSLTIV-FYIWQRRTLSFWERHGVKYIR----PFPVVGCT----REFLTAKVPFFEQIQ 57

  Fly    64 K-------SKERVLGIYLLFRPAVLIRDADLARRVLAQDFASFHDRGVYVDEERDPLS-ANIFSL 120
            |       ..|..:|:|:..|||::|||.:|.:.|:.:.|..|::|.:..|...|.|. .|:|..
  Fly    58 KFHEAPGFENEPFVGVYMTHRPALVIRDLELIKTVMIKKFQYFNNRVLQTDPHNDALGYKNLFFA 122

  Fly   121 RGQSWRSMRHMLSPCFTSGKLKSMFSTSEDIGDKMVAHLQKELPEEGF-KEVDIKKVMQNYAIDI 184
            |...||.:|..:||.|||||:|.|:.....||    .:||......|. .||.:|.:...:..|:
  Fly   123 RSPGWRELRTKISPVFTSGKIKQMYPLMVKIG----KNLQDSAERLGSGTEVQVKDLCSRFTTDL 183

  Fly   185 IASTIFGLDVNSFENPDNKF----RKLVSLARANNRFNAMFGMMIFLVPSIAQFLFRIGFKNPVG 245
            ||:..||::.|:.::..::|    |.:.||..:.....|    :||::|::|. |.|:..   ..
  Fly   184 IATIAFGVEANALQDAKSEFFYHNRAIFSLTLSRGIDFA----IIFMIPALAS-LARVKL---FS 240

  Fly   246 LAMLQIVKETVEY----REKHGIVRKDLLQLLIQLR-----NTGKIDENDEKSFSIQKTPDGHIK 301
            ....:.::.:|.|    ||:.|..|.||:.:|:.|:     |.||:.                 |
  Fly   241 RETTKFIRSSVNYVLKERERTGEKRNDLIDILLALKREAAANPGKMS-----------------K 288

  Fly   302 TISLEAITAQAFIFYIAGQETTGSTAAFTIYELAQYPELLKRLQDEVDETLAKNDGKITYDSLNK 366
            .:.|:.:.|||.:|..||.||:.||...|:||||:...|..||:.|:.:.....| .|:|:.:.:
  Fly   289 EVDLDYLVAQAAVFQTAGFETSASTMTMTLYELAKNEALQDRLRQEIVDFFGDED-HISYERIQE 352

  Fly   367 MEFLDLCVQETIRKYPGLPILNRECTQD-----YTV-PDTNHVIPKGTPVVISLYGIHHDAEYFP 425
            |.:|...|.||:||||.:..:.|||:|.     :|: |..|..:|.|..:.:|...:|.|.:|:|
  Fly   353 MPYLSQVVNETLRKYPIVGYIERECSQPAEGERFTLEPFHNMELPHGMSIYMSTVAVHRDPQYWP 417

  Fly   426 DPETYDPERFSEESR-NYNPTAFMPFGEGPRICIAQRMGRINSKLAIIKILQNFNVEVMSRS--E 487
            |||.||||||:..:| |.|..|:||||.|||.||..|:|.:.|||.::.||:|.......::  :
  Fly   418 DPEKYDPERFNSSNRDNLNMDAYMPFGVGPRNCIGMRLGLLQSKLGLVHILRNHRFHTCDKTIKK 482

  Fly   488 IEFENSGIALIPKHGVRVRLSK 509
            ||:..:...:..|..:.:|:.|
  Fly   483 IEWAPTSPVMASKRDIILRVEK 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d4	NP_651082.1	p450	58..500	CDD:278495	150/472 (32%)
Cyp6w1	NP_001286145.1	p450	34..501	CDD:278495	156/504 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461025
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3345
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	10	9.900