DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6d4 and Cyp3a44

DIOPT Version :9

Sequence 1:	NP_651082.1	Gene:	Cyp6d4 / 42682	FlyBaseID:	FBgn0039006	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_796354.1	Gene:	Cyp3a44 / 337924	MGIID:	2449818	Length:	504	Species:	Mus musculus

Alignment Length:	534	Identity:	179/534 - (33%)
Similarity:	291/534 - (54%)	Gaps:	73/534 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SLILLAVTLLTLAWFYLKRHYEYWERRGFPFEKHSGIPF-----GCLDSVWRQEKSMGLAIYDVY 62
            :|:|||: :|.|.:.|..|.:..::::|.|..|  .:||     .....:|:    ..:..|:.|
Mouse    11 TLVLLAI-ILVLLYRYGTRTHGLFKKQGIPGPK--PLPFLGTVLNYYTGIWK----FDMECYEKY 68

  Fly    63 VKSKERVLGIYLLFRPAVLIRDADLARRVLAQDFAS-FHDRGVYVDEERDP---LSANIFSLRGQ 123
            .|:    .|::....|.::|.|.:..:.||.:|..| |.:|     .|..|   :|..|...:.:
Mouse    69 GKT----WGLFDGQTPLLVITDPETIKNVLVKDCLSVFTNR-----REFGPVGIMSKAISISKDE 124

  Fly   124 SWRSMRHMLSPCFTSGKLKSMFSTSEDIGDKMVAHLQKELPEEGFKEVDIKKVMQNYAIDIIAST 188
            .|:..|.:|||.||||:||.||...|..||.:|.:|::| .|:|. .|.:|.|:..|::|:|.||
Mouse   125 EWKRYRALLSPTFTSGRLKEMFPVIEQYGDILVKYLRQE-AEKGM-PVAMKDVLGAYSMDVITST 187

  Fly   189 IFGLDVNSFENPDNKFRKLVSLARANNRFN----AMFGMMIF-LVPSIAQFLFRIGFKNPVGLAM 248
            .||::|:|..||::.|   |..|:...|.:    .:|.:::| |:..:.:.|....|.|.    .
Mouse   188 SFGVNVDSLNNPEDPF---VEEAKKFLRVDFFDPLLFSVVLFPLLTPVYEMLNICMFPND----S 245

  Fly   249 LQIVKETV--------EYREKHGIVRKDLLQLLIQLRNTGKIDENDEKSFSIQKTPDGHIKTISL 305
            ::..|:.|        :..:||   |.|.|||::...|..| |::..|:||            ::
Mouse   246 IEFFKKFVDRMQESRLDSNQKH---RVDFLQLMMNSHNNSK-DKDSHKAFS------------NM 294

  Fly   306 EAITAQAFIFYIAGQETTGSTAAFTIYELAQYPELLKRLQDEVDETLAKNDGKITYDSLNKMEFL 370
            | ||.|:.||..||.|||.||.:||:|.||.:|::.|:||.|:|:.| .|....|.|::.:||:|
Mouse   295 E-ITVQSIIFISAGYETTSSTLSFTLYCLATHPDIQKKLQAEIDKAL-PNKATPTCDTVMEMEYL 357

  Fly   371 DLCVQETIRKYPGLPILNRECTQDYTVPDTNHV-IPKGTPVVISLYGIHHDAEYFPDPETYDPER 434
            |:.:.||:|.||.:..|.|.|.:|.   :.|.| ||||:.|:|..|.:|||.:::||||.:.|||
Mouse   358 DMVLNETLRLYPIVTRLERVCKKDV---ELNGVYIPKGSMVMIPSYALHHDPQHWPDPEEFQPER 419

  Fly   435 FSEESR-NYNPTAFMPFGEGPRICIAQRMGRINSKLAIIKILQNFNVEVMSRSEI--EFENSGIA 496
            ||:|:: :.:|..::|||.|||.||..|...:|.|||:.|:||||:.:....::|  :....||
Mouse   420 FSKENKGSIDPYVYLPFGIGPRNCIGMRFALMNMKLAVTKVLQNFSFQPCQETQIPLKLSRQGI- 483

  Fly   497 LIPKHGVRVRLSKR 510
            |.|:..:.:::..|
Mouse   484 LQPEKPIVLKVVPR 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d4	NP_651082.1	p450	58..500	CDD:278495	163/462 (35%)
Cyp3a44	NP_796354.1	p450	39..494	CDD:278495	169/500 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820