Protein Alignment Cyp6d4 and Cyp3a44

DIOPT Version :10

• Sequence 1: NP_651082.1
• Gene: Cyp6d4 / 42682
• FlyBaseID: FBgn0039006
• Length: 515
• Species: Drosophila melanogaster
• Sequence 2: NP_796354.1
• Gene: Cyp3a44 / 337924
• MGIID: 2449818
• Length: 504
• Species: Mus musculus
• Alignment Length: 534
• Identity: 179/534 - (33%)
• Similarity: 291/534 - (54%)
• Gaps: 73/534 - (13%)

  Fly     3 SLILLAVTLLTLAWFYLKRHYEYWERRGFPFEKHSGIPF-----GCLDSVWRQEKSMGLAIYDVY 62
            :|:|||: :|.|.:.|..|.:..::::|.|..|  .:||     .....:|:    ..:..|:.|
Mouse    11 TLVLLAI-ILVLLYRYGTRTHGLFKKQGIPGPK--PLPFLGTVLNYYTGIWK----FDMECYEKY 68

  Fly    63 VKSKERVLGIYLLFRPAVLIRDADLARRVLAQDFAS-FHDRGVYVDEERDP---LSANIFSLRGQ 123
            .|:    .|::....|.::|.|.:..:.||.:|..| |.:|     .|..|   :|..|...:.:
Mouse    69 GKT----WGLFDGQTPLLVITDPETIKNVLVKDCLSVFTNR-----REFGPVGIMSKAISISKDE 124

  Fly   124 SWRSMRHMLSPCFTSGKLKSMFSTSEDIGDKMVAHLQKELPEEGFKEVDIKKVMQNYAIDIIAST 188
            .|:..|.:|||.||||:||.||...|..||.:|.:|::| .|:|. .|.:|.|:..|::|:|.||
Mouse   125 EWKRYRALLSPTFTSGRLKEMFPVIEQYGDILVKYLRQE-AEKGM-PVAMKDVLGAYSMDVITST 187

  Fly   189 IFGLDVNSFENPDNKFRKLVSLARANNRFN----AMFGMMIF-LVPSIAQFLFRIGFKNPVGLAM 248
            .||::|:|..||::.|   |..|:...|.:    .:|.:::| |:..:.:.|....|.|.    .
Mouse   188 SFGVNVDSLNNPEDPF---VEEAKKFLRVDFFDPLLFSVVLFPLLTPVYEMLNICMFPND----S 245

  Fly   249 LQIVKETV--------EYREKHGIVRKDLLQLLIQLRNTGKIDENDEKSFSIQKTPDGHIKTISL 305
            ::..|:.|        :..:||   |.|.|||::...|..| |::..|:||            ::
Mouse   246 IEFFKKFVDRMQESRLDSNQKH---RVDFLQLMMNSHNNSK-DKDSHKAFS------------NM 294

  Fly   306 EAITAQAFIFYIAGQETTGSTAAFTIYELAQYPELLKRLQDEVDETLAKNDGKITYDSLNKMEFL 370
            | ||.|:.||..||.|||.||.:||:|.||.:|::.|:||.|:|:.| .|....|.|::.:||:|
Mouse   295 E-ITVQSIIFISAGYETTSSTLSFTLYCLATHPDIQKKLQAEIDKAL-PNKATPTCDTVMEMEYL 357

  Fly   371 DLCVQETIRKYPGLPILNRECTQDYTVPDTNHV-IPKGTPVVISLYGIHHDAEYFPDPETYDPER 434
            |:.:.||:|.||.:..|.|.|.:|.   :.|.| ||||:.|:|..|.:|||.:::||||.:.|||
Mouse   358 DMVLNETLRLYPIVTRLERVCKKDV---ELNGVYIPKGSMVMIPSYALHHDPQHWPDPEEFQPER 419

  Fly   435 FSEESR-NYNPTAFMPFGEGPRICIAQRMGRINSKLAIIKILQNFNVEVMSRSEI--EFENSGIA 496
            ||:|:: :.:|..::|||.|||.||..|...:|.|||:.|:||||:.:....::|  :....||
Mouse   420 FSKENKGSIDPYVYLPFGIGPRNCIGMRFALMNMKLAVTKVLQNFSFQPCQETQIPLKLSRQGI- 483

  Fly   497 LIPKHGVRVRLSKR 510
            |.|:..:.:::..|
Mouse   484 LQPEKPIVLKVVPR 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d4	NP_651082.1	CYP6-like	66..504	CDD:410679	161/458 (35%)
Cyp3a44	NP_796354.1	CYP3A	67..493	CDD:410743	163/465 (35%)