DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6d4 and cyp3c1

DIOPT Version :9

Sequence 1:	NP_651082.1	Gene:	Cyp6d4 / 42682	FlyBaseID:	FBgn0039006	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_997838.1	Gene:	cyp3c1 / 324340	ZFINID:	ZDB-GENE-030131-3060	Length:	505	Species:	Danio rerio

Alignment Length:	531	Identity:	164/531 - (30%)
Similarity:	271/531 - (51%)	Gaps:	58/531 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FSLILLAVTLLTLAWFYLKRHYEYWERRGFPFEKHSGIP-------FGCLDSVWRQEKSMGLAIY 59
            ::|::|.:|||.:        |..|..   .|.|..|||       .|...|.     |.|:..:
Zfish    11 WTLVVLVITLLLI--------YGVWPH---GFFKKLGIPGPRPLPFVGTALSY-----SKGICNF 59

  Fly    60 DVYVKSK-ERVLGIYLLFRPAVLIRDADLARRVLAQD-FASFHDRGVYVDEERDPLSANIFSLRG 122
            |:....| .:|.|||....|.:|:.|.::.:.:|.:| :::|.:|.....:...|.:..|..::.
Zfish    60 DIECSKKYGKVWGIYDGRLPLLLVTDLEMIKTILVKDCYSTFTNRRNMNPDLVGPFADGITLVKD 124

  Fly   123 QSWRSMRHMLSPCFTSGKLKSMFSTSEDIGDKMVAHLQKELPEEGFKEVDIKKVMQNYAIDIIAS 187
            :.||.:|..|||.||||:||.:|..:....|:.:.:::|:.|....|   ||.|:..|::|::||
Zfish   125 ERWRRIRSSLSPYFTSGRLKEIFPIAMTHADRFIKNMEKKDPNLPLK---IKDVVAPYSLDVVAS 186

  Fly   188 TIFGLDVNSFENPDNKFRKLVSLARANNRFNAMFGMMIFLVPSIAQFLFRIGFK------NPVGL 246
            :.|.:|.:|..|||:.|...:......|..:.:|.::.| .||.|..|.::|..      .....
Zfish   187 SSFSVDFDSINNPDDPFVTSIKSFFNINPLSPLFLLLAF-CPSAANLLAKMGISVFSRSTTDFYY 250

  Fly   247 AMLQIVKETVEYREKHGIVRKDLLQLLIQLRNTGKIDENDEKSFSIQKTPDGHIKTISLEAITAQ 311
            ..|:.:|:  |:.|.:|  |.|.|:|:||    .:|.::..|..:.::.    :|.::...|.:|
Zfish   251 KALRKIKD--EHNESNG--RVDFLKLMIQ----NQIPDDQVKDTASEQP----VKGLTDHEILSQ 303

  Fly   312 AFIFYIAGQETTGSTAAFTIYELAQYPELLKRLQDEVDETLAKN---DGKITYDSLNKMEFLDLC 373
            :|||.:.|.|||.:|.::.:|.||..|:.|::|.:|:|    ||   |..||||:|.:|::|::.
Zfish   304 SFIFILGGYETTSTTLSYLLYNLATNPDCLEKLVEEID----KNFPLDIPITYDALMRMDYLEMA 364

  Fly   374 VQETIRKYPGLPILNRECTQDYTVPDTNHVIPKGTPVVISLYGIHHDAEYFPDPETYDPERFSEE 438
            :.|::|.:|..|.|.|.|.:  ||......|||.|.|.|.||.:..|.:.:..|..:.|||||.|
Zfish   365 IHESMRVFPAGPRLERVCKK--TVEINGITIPKNTLVGIPLYVLSRDPDLWESPNEFKPERFSPE 427

  Fly   439 SR-NYNPTAFMPFGEGPRICIAQRMGRINSKLAIIKILQNFNVEVMSRSEIEFENSGIALIPKHG 502
            |: ..|..||||||.|||.||..|...:..||.::|:||.:.||....::|..: ......||..
Zfish   428 SKTEINQCAFMPFGLGPRNCIGMRFALMMMKLLVVKLLQKYTVETCKETQIPVQ-LNFFFQPKVP 491

  Fly   503 VRVRLSKRVPK 513
            :.::|..|..|
Zfish   492 ITLKLIPRSHK 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d4	NP_651082.1	p450	58..500	CDD:278495	143/453 (32%)
cyp3c1	NP_997838.1	p450	38..496	CDD:278495	150/485 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	226	1.000	Domainoid score	I2453
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8426
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.820