Protein Alignment Cyp6d4 and CYP4A22

DIOPT Version :10

• Sequence 1: NP_651082.1
• Gene: Cyp6d4 / 42682
• FlyBaseID: FBgn0039006
• Length: 515
• Species: Drosophila melanogaster
• Sequence 2: NP_001010969.2
• Gene: CYP4A22 / 284541
• HGNCID: 20575
• Length: 519
• Species: Homo sapiens
• Alignment Length: 550
• Identity: 139/550 - (25%)
• Similarity: 233/550 - (42%)
• Gaps: 102/550 - (18%)

  Fly     3 SLILLAVTLLTLAWFYLKRHYEYWERRGFPFEKHSGIPFGCLDSVWR----QEKSMGLAIYDVYV 63
            ||::|.:.|:..|..||.|.:.....:.||          |..|.|.    ||......:..:
Human    23 SLLILLLLLIKAAQLYLHRQWLLKALQQFP----------CPPSHWLFGHIQEFQHDQELQRI-- 75

  Fly    64 KSKERVLGI-----YLLF--RPAVLIRDADLARRVLAQDFASFHDRGVYVDEERDPLSANIFSLR 121
              :|||...     |.::  :..|.:.|.|..:.:|.:.....|....::...   :...:..|.
Human    76 --QERVKTFPSACPYWIWGGKVRVQLYDPDYMKVILGRSDPKSHGSYKFLAPR---IGYGLLLLN 135

  Fly   122 GQSWRSMRHMLSPCFTSGKLKSMFSTSED----IGDKMVAHLQKELPEEGFKEV----------- 171
            ||:|...|.||:|.|.:..||.......|    :.||....|.::.|.|.|:.|
Human   136 GQTWFQHRRMLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKS 200

  Fly   172 --------DIKKVMQNY--AIDIIASTIFGLDVNSFENPDNKFRKLVSLARANNRFNAMFGMMIF 226
                    .:.:..|:|  ||..:.|.:|....|:|...|..: .|.|..|..:|
Human   201 AFSHQGSIQVDRNSQSYIQAISDLNSLVFCCMRNAFHENDTIY-SLTSAGRWTHR---------- 254

  Fly   227 LVPSIAQFLFRIGFKNPVGLAMLQIVKETVEYREKHGIVRK---DLLQLLIQLRNTGKIDENDEK 288
                 |..|........:.|...|:.||    .|...|.||   |.|.:|:
Human   255 -----ACQLAHQHTDQVIQLRKAQLQKE----GELEKIKRKRHLDFLDILL-------------- 296

  Fly   289 SFSIQKTPDGHIKTISLEAITAQAFIFYIAGQETTGSTAAFTIYELAQYPELLKRLQDEVDETLA 353
               :.|..:|.|  :|.:.:.|:...|...|.:||.|..::.:|.||.:|:..:|.::|:...|
Human   297 ---LAKMENGSI--LSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERCREEIHGLL- 355

  Fly   354 KNDG-KITYDSLNKMEFLDLCVQETIRKYPGLPILNRECTQDYTVPDTNHVIPKGTPVVISLYGI 417
             .|| .||::.|::|.:..:|::|.:|.||.:|.:.||.:...|.|| ...:|||..|::|:||:
Human   356 -GDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPD-GRSLPKGIMVLLSIYGL 418

  Fly   418 HHDAEYFPDPETYDPERFSEESRNYNPTAFMPFGEGPRICIAQRMGRINSKLAIIKILQNFNVEV 482
            ||:.:.:|:.|.:||.||:..|..:: .||:||..|.|.||.::......|:|....|..|.: :
Human   419 HHNPKVWPNLEVFDPSRFAPGSAQHS-HAFLPFSGGSRNCIGKQFAMNQLKVARALTLLRFEL-L 481

  Fly   483 MSRSEIEFENSGIALIPKHGVRVRLSKRVP 512
            ...:.|....:.:.|..|:|:.:|| :|:|
Human   482 PDPTRIPIPMARLVLKSKNGIHLRL-RRLP 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d4	NP_651082.1	CYP6-like	66..504	CDD:410679	120/473 (25%)
CYP4A22	NP_001010969.2	CYP4B-like	72..505	CDD:410771	120/483 (25%)