Protein Alignment Cyp6d4 and CYP4Z1

DIOPT Version :10

• Sequence 1: NP_651082.1
• Gene: Cyp6d4 / 42682
• FlyBaseID: FBgn0039006
• Length: 515
• Species: Drosophila melanogaster
• Sequence 2: NP_835235.1
• Gene: CYP4Z1 / 199974
• HGNCID: 20583
• Length: 505
• Species: Homo sapiens
• Alignment Length: 576
• Identity: 133/576 - (23%)
• Similarity: 233/576 - (40%)
• Gaps: 156/576 - (27%)

  Fly     4 LILLAVTLL--TLAWFYLKR---------------HYEYWERRGFPFEKHSGIPFGCLDSVWRQE 51
            ||||.::||  .:...|.:|               |:.|..:..:|.::
Human    17 LILLCMSLLLFQVIRLYQRRRWMIRALHLFPAPPAHWFYGHKEFYPVKE---------------- 65

  Fly    52 KSMGLAIYDVYVKSKERV-------LGIYLLFRPAVLIRDADLARRVLAQDFASFHDRGVYVDEE 109
                   ::||.|..|:.       :|.:.:|   ..:.|.|.|:.:|               :.
Human    66 -------FEVYHKLMEKYPCAVPLWVGPFTMF---FSVHDPDYAKILL---------------KR 105

  Fly   110 RDPLSA------------NIFSLRGQSWRSMRHMLSPCFTSGKLKSMFST--SEDIG---DKMVA 157
            :||.||            .:.:|.|..|:..|.::.|.|....|| :|.|  ||.:.   :|...
Human   106 QDPKSAVSHKILESWVGRGLVTLDGSKWKKHRQIVKPGFNISILK-IFITMMSESVRMMLNKWEE 169

  Fly   158 HLQKELPEEGFKEVDIK--------------KVMQNYAIDIIASTIFGLD------VNSFENPDN 202
            |:.:....|.|:.|.:.              .:..:..:|.....:|.|.      :|:|.:.::
Human   170 HIAQNSRLELFQHVSLMTLDSIMKCAFSHQGSIQLDSTLDSYLKAVFNLSKISNQRMNNFLHHND 234

  Fly   203 KFRKLVSLARANNRFNAMFGMMIFLVPSIAQFLFRIGFKNPVGLAMLQIVKETVEYREKHGIVRK 267
            ...|..|..:..::||          ..:.||..::          :|..||:::.:.|....:|
Human   235 LVFKFSSQGQIFSKFN----------QELHQFTEKV----------IQDRKESLKDKLKQDTTQK 279

  Fly   268 ---DLLQLLIQLR--NTGKIDENDEKSFSIQKTPDGHIKTISLEAITAQAFIFYIAGQETTGSTA 327
               |.|.:|:..:  ||....|.|                     :.|:...|..||.:||.|..
Human   280 RRWDFLDILLSAKSENTKDFSEAD---------------------LQAEVKTFMFAGHDTTSSAI 323

  Fly   328 AFTIYELAQYPELLKRLQDEVDETLAKNDG-KITYDSLNKMEFLDLCVQETIRKYPGLPILNREC 391
            ::.:|.||:|||..:|.:||:.|.|  .|| .||::.|::|.:..:|::|.:|.|..:..::|..
Human   324 SWILYCLAKYPEHQQRCRDEIRELL--GDGSSITWEHLSQMPYTTMCIKECLRLYAPVVNISRLL 386

  Fly   392 TQDYTVPDTNHVIPKGTPVVISLYGIHHDAEYFPDPETYDPERFS-EESRNYNPTAFMPFGEGPR 455
            .:..|.|| ...:|.|..|.|:::.:||:..::.||:.::|.||| |.|...:|.||:||..|.|
Human   387 DKPITFPD-GRSLPAGITVFINIWALHHNPYFWEDPQVFNPLRFSRENSEKIHPYAFIPFSAGLR 450

  Fly   456 ICIAQRMGRINSKLAIIKILQNFNVEVMSRSEIEFENSGIALIPKHGVRVRLSKRV 511
            .||.|....|..|:|:...|..|.: ....|........:.|..|:|:.| .:|:|
Human   451 NCIGQHFAIIECKVAVALTLLRFKL-APDHSRPPQPVRQVVLKSKNGIHV-FAKKV 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d4	NP_651082.1	CYP6-like	66..504	CDD:410679	116/488 (24%)
CYP4Z1	NP_835235.1	CYP4B-like	66..500	CDD:410771	120/498 (24%)