Protein Alignment Cyp6d4 and CYP27A1

DIOPT Version :10

• Sequence 1: NP_651082.1
• Gene: Cyp6d4 / 42682
• FlyBaseID: FBgn0039006
• Length: 515
• Species: Drosophila melanogaster
• Sequence 2: NP_000775.1
• Gene: CYP27A1 / 1593
• HGNCID: 2605
• Length: 531
• Species: Homo sapiens
• Alignment Length: 552
• Identity: 114/552 - (20%)
• Similarity: 214/552 - (38%)
• Gaps: 131/552 - (23%)

  Fly    32 PFEKHSGIPFGCLDSVWRQEKSM--------------------GLAIYDVYVKSKERVLGIYLLF 76
            |.:|.:|.| |....|.|:::|:                    .|.::.:.|..|.:...:::.:
Human    36 PSDKATGAP-GAGPGVRRRQRSLEEIPRLGQLRFFFQLFVQGYALQLHQLQVLYKAKYGPMWMSY 99

  Fly    77 ---RPAVLIRDADLARRVLAQD--FASFHDRGVYVDEERD--PLSANIFSLRGQSWRSMRHMLSP 134
               :..|.:..|.|..:|:.|:  :...:|..:: .|.||  .|:...|:..|..|..:|..|:
Human   100 LGPQMHVNLASAPLLEQVMRQEGKYPVRNDMELW-KEHRDQHDLTYGPFTTEGHHWYQLRQALN- 162

  Fly   135 CFTSGKLKSMFSTSEDIGDKMVAHLQKELPEEGFKEVDIKKVMQNYAIDIIASTIFGLDVNSFEN 199
                              .:::...:..|..:.|.||          ||...:.:..|...|...
Human   163 ------------------QRLLKPAEAALYTDAFNEV----------IDDFMTRLDQLRAESASG 199

  Fly   200 PDNKFRKLVSLARANNRFNAMFGMMIFLVPSIAQFLFRIGFKNPVGLAMLQIVKETVEYREKHGI 264
              |:...:..|            ...|.:.:|...|    |:..:|.....|.::||.:....|:
Human   200 --NQVSDMAQL------------FYYFALEAICYIL----FEKRIGCLQRSIPEDTVTFVRSIGL 246

  Fly   265 VRKDLLQLLIQLRNT--------------------GK--IDEN-DEKSFSIQKT-PDG------- 298
            :.::.|......:.|                    ||  |||. ::....:|.. |||
Human   247 MFQNSLYATFLPKWTRPVLPFWKRYLDGWNAIFSFGKKLIDEKLEDMEAQLQAAGPDGIQVSGYL 311

  Fly   299 HIKTISLEAITAQAF----IFYIAGQETTGSTAAFTIYELAQYPELLKRLQDEVDETLAKNDGKI 359
            |....|.:....:|.    ...:||.:||.:|..:.:|.|::.||:.:.|.:||...:..  |::
Human   312 HFLLASGQLSPREAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPA--GQV 374

  Fly   360 -TYDSLNKMEFLDLCVQETIRKYPGLP----ILNRECTQDYTVPDTNHVIPKGTPVVISLYGIHH 419
             .:.....|..|...::||:|.||.:|    |:.:|...|      ..:.||.|..|...|.:..
Human   375 PQHKDFAHMPLLKAVLKETLRLYPVVPTNSRIIEKEIEVD------GFLFPKNTQFVFCHYVVSR 433

  Fly   420 DAEYFPDPETYDPERFSEES-----RNYNPTAFMPFGEGPRICIAQRMGRINSKLAIIKILQNFN 479
            |...|.:||::.|.|:...|     |..:|...:|||.|.|.|:.:|:..:..:|.:.:::|.:.
Human   434 DPTAFSEPESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYK 498

  Fly   480 VEVMSRSEIEFEN-SGIALIPKHGVRVRLSKR 510
            | |::....|.:: :.|.|:|...|.::..:|
Human   499 V-VLAPETGELKSVARIVLVPNKKVGLQFLQR 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d4	NP_651082.1	CYP6-like	66..504	CDD:410679	102/490 (21%)
CYP27A1	NP_000775.1	cytochrome_P450	89..524	CDD:477761	103/491 (21%)
		Sterol-binding. /evidence=ECO:0000255	384..398		4/13 (31%)