Protein Alignment Cyp6d4 and CYP26A1

DIOPT Version :10

• Sequence 1: NP_651082.1
• Gene: Cyp6d4 / 42682
• FlyBaseID: FBgn0039006
• Length: 515
• Species: Drosophila melanogaster
• Sequence 2: NP_000774.2
• Gene: CYP26A1 / 1592
• HGNCID: 2603
• Length: 497
• Species: Homo sapiens
• Alignment Length: 485
• Identity: 108/485 - (22%)
• Similarity: 206/485 - (42%)
• Gaps: 95/485 - (19%)

  Fly    30 GFPFEKHSGIPFG-CLDSVWRQEKSMGLAIYDVYVKSKERVLGI----YLLFRPAVLIRDADLAR 89
            ||||       || .|..|.::.|         :::.|.|..|.    :|..||.|.:..||..|
Human    50 GFPF-------FGETLQMVLQRRK---------FLQMKRRKYGFIYKTHLFGRPTVRVMGADNVR 98

  Fly    90 RVLAQD--FASFHDRGVYVDEERDPLSANIFS-LRGQSWRSMRHMLSPCFTSGKLKSMFST-SED 150
            |:|..:  ..|.|    :....|..|.:...| |...|.:..:.::...|:...|:..... :|:
Human    99 RILLGEHRLVSVH----WPASVRTILGSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEE 159

  Fly   151 IGDKMVAHLQKELPEEGFKEV-DIKKVMQNYAIDIIASTIFGLDVNSFENPDNKFRKLVSLARAN 214
            :|..:...|  ...|.|.... ::|::|...|:.|    :.|.:.....:.|:: ::||......
Human   160 VGSSLEQWL--SCGERGLLVYPEVKRLMFRIAMRI----LLGCEPQLAGDGDSE-QQLVEAFEEM 217

  Fly   215 NRFNAMFGMMIFLVPSIAQF--LFRIGFKNPVGLAMLQIVKETVEYR----------EKHGIVRK 267
            .|       .:|.:|....|  |:|       |:....::...:|..          .:.|...|
Human   218 TR-------NLFSLPIDVPFSGLYR-------GMKARNLIHARIEQNIRAKICGLRASEAGQGCK 268

  Fly   268 DLLQLLIQLRNTGKIDENDEKSFSIQKTPDGHIKTISLEAITAQAFIFYIAGQETTGSTAAFTIY 332
            |.||||        |:.:.|:.           :.:.::|:...:......|.|||.|.|...|.
Human   269 DALQLL--------IEHSWERG-----------ERLDMQALKQSSTELLFGGHETTASAATSLIT 314

  Fly   333 ELAQYPELLKRLQDEVDE--TLAKN--DGKITYDSLNKMEFLDLCVQETIRKYPGLPILNRECTQ 393
            .|..||.:|:::::|:..  .|.|:  |.|:..:.|.:::::...::||:|..|.:|...|...:
Human   315 YLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVIKETLRLNPPVPGGFRVALK 379

  Fly   394 DYTVPDTNHVIPKGTPVVISLYGIHHDAEYFPDPETYDPERF----SEESRNYNPTAFMPFGEGP 454
            .:.:  ..:.||||..|:.|:...|..||.|.:.|.::|:||    .|::..:   :|:|||.|.
Human   380 TFEL--NGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFMLPHPEDASRF---SFIPFGGGL 439

  Fly   455 RICIAQRMGRINSKLAIIKILQNFNVEVMS 484
            |.|:.:...:|..|:..:::.::.:.::::
Human   440 RSCVGKEFAKILLKIFTVELARHCDWQLLN 469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d4	NP_651082.1	CYP6-like	66..504	CDD:410679	99/448 (22%)
CYP26A1	NP_000774.2	CYP26A1	55..490	CDD:410731	103/473 (22%)