Protein Alignment Cyp6d4 and CYP4A11

DIOPT Version :10

• Sequence 1: NP_651082.1
• Gene: Cyp6d4 / 42682
• FlyBaseID: FBgn0039006
• Length: 515
• Species: Drosophila melanogaster
• Sequence 2: NP_000769.2
• Gene: CYP4A11 / 1579
• HGNCID: 2642
• Length: 519
• Species: Homo sapiens
• Alignment Length: 559
• Identity: 139/559 - (24%)
• Similarity: 231/559 - (41%)
• Gaps: 120/559 - (21%)

  Fly     3 SLILLAVTLLTLAWFYLKRHYEYWERRGFPFEKHSGIPFGCLDSVW--------RQEKSMGLAIY 59
            ||::|.:.|:.....||.|.:.....:.||          |..|.|        :|::.:
Human    23 SLLILLLLLIKAVQLYLHRQWLLKALQQFP----------CPPSHWLFGHIQELQQDQEL----- 72

  Fly    60 DVYVKSKERVLGIYLLFRPA-----------VLIRDADLARRVLAQDFASFHDRGVYVDEERDP- 112
                   :|:......|..|           |.:.|.|..:.:|.:.....|  |.|  ....|
Human    73 -------QRIQKWVETFPSACPHWLWGGKVRVQLYDPDYMKVILGRSDPKSH--GSY--RFLAPW 126

  Fly   113 LSANIFSLRGQSWRSMRHMLSPCFTSGKLKSMFSTSED----IGDKMVAHLQKELPEEGFKEV-- 171
            :...:..|.||:|...|.||:|.|....||.......|    :.||....|.::.|.|.|:.|
Human   127 IGYGLLLLNGQTWFQHRRMLTPAFHYDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSL 191

  Fly   172 -----------------DIKKVMQNY--AIDIIASTIFGLDVNSFENPDNKFRKLVSLARANNRF 217
                             .:.:..|:|  ||..:.:.:|....|:|...|..: .|.|..|..:|
Human   192 MTLDTIMKCAFSHQGSIQVDRNSQSYIQAISDLNNLVFSRVRNAFHQNDTIY-SLTSAGRWTHR- 254

  Fly   218 NAMFGMMIFLVPSIAQFLFRIGFKNPVGLAMLQIVKETVEYREKHGIVRK---DLLQLLIQLRNT 279
                          |..|........:.|...|:.||    .|...|.||   |.|.:|:
Human   255 --------------ACQLAHQHTDQVIQLRKAQLQKE----GELEKIKRKRHLDFLDILL----- 296

  Fly   280 GKIDENDEKSFSIQKTPDGHIKTISLEAITAQAFIFYIAGQETTGSTAAFTIYELAQYPELLKRL 344
                        :.|..:|.|  :|.:.:.|:...|...|.:||.|..::.:|.||.:|:..:|.
Human   297 ------------LAKMENGSI--LSDKDLRAEVDTFMFEGHDTTASGISWILYALATHPKHQERC 347

  Fly   345 QDEVDETLAKNDG-KITYDSLNKMEFLDLCVQETIRKYPGLPILNRECTQDYTVPDTNHVIPKGT 408
            ::|:...|  .|| .||::.|::|.:..:|::|.:|.||.:|.:.||.:...|.|| ...:|||.
Human   348 REEIHSLL--GDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIGRELSTPVTFPD-GRSLPKGI 409

  Fly   409 PVVISLYGIHHDAEYFPDPETYDPERFSEESRNYNPTAFMPFGEGPRICIAQRMGRINSKLAIIK 473
            .|::|:||:||:.:.:|:||.:||.||:..|..:: .||:||..|.|.||.::......|:|...
Human   410 MVLLSIYGLHHNPKVWPNPEVFDPFRFAPGSAQHS-HAFLPFSGGSRNCIGKQFAMNELKVATAL 473

  Fly   474 ILQNFNVEVMSRSEIEFENSGIALIPKHGVRVRLSKRVP 512
            .|..|.: :...:.|....:.:.|..|:|:.:|| :|:|
Human   474 TLLRFEL-LPDPTRIPIPIARLVLKSKNGIHLRL-RRLP 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d4	NP_651082.1	CYP6-like	66..504	CDD:410679	122/478 (26%)
CYP4A11	NP_000769.2	CYP4B-like	74..505	CDD:410771	122/478 (26%)