Protein Alignment Cyp6d4 and CYP3A5

DIOPT Version :10

• Sequence 1: NP_651082.1
• Gene: Cyp6d4 / 42682
• FlyBaseID: FBgn0039006
• Length: 515
• Species: Drosophila melanogaster
• Sequence 2: NP_000768.1
• Gene: CYP3A5 / 1577
• HGNCID: 2638
• Length: 502
• Species: Homo sapiens
• Alignment Length: 538
• Identity: 179/538 - (33%)
• Similarity: 279/538 - (51%)
• Gaps: 77/538 - (14%)

  Fly     5 ILLAVTLLTLAWFYLKRHYEYWERRGFPFEKHSGIPFGCLDSV--WRQEKSMGLAIYDV-YVKSK 66
            :||||:|: |.:.|..|.:..::|.|.|    ...|...|.:|  :||    ||..:|. ..|..
Human    13 LLLAVSLV-LLYLYGTRTHGLFKRLGIP----GPTPLPLLGNVLSYRQ----GLWKFDTECYKKY 68

  Fly    67 ERVLGIYLLFRPAVLIRDADLARRVLAQD-FASFHDRGVYVDEERDP---LSANIFSLRGQSWRS 127
            .::.|.|....|.:.|.|.|:.|.||.:: ::.|.:|     ....|   :.:.|.....:.|:.
Human    69 GKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNR-----RSLGPVGFMKSAISLAEDEEWKR 128

  Fly   128 MRHMLSPCFTSGKLKSMFSTSEDIGDKMVAHLQKELPEEGFKEVDIKKVMQNYAIDIIASTIFGL 192
            :|.:|||.|||||||.||......||.:|.:|::| .|:| |.|.:|.:...|::|:|..|.||:
Human   129 IRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRRE-AEKG-KPVTLKDIFGAYSMDVITGTSFGV 191

  Fly   193 DVNSFENPDNKFRKLVSLARANNRFNAMFGMMIFLVPSIAQFLFRIGFKNPV--GLAMLQIVKET 255
            :::|..||.:.|      ..:..:| ..||.:..|..||..|    .|..||  .|.:....|:|
Human   192 NIDSLNNPQDPF------VESTKKF-LKFGFLDPLFLSIILF----PFLTPVFEALNVSLFPKDT 245

  Fly   256 VEY---------------REKHGIVRKDLLQLLIQLRNTGKIDENDEKSFSIQKTPDGHIKTISL 305
            :.:               ::||   |.|.|||:|..:|:              |..:.| |.:|.
Human   246 INFLSKSVNRMKKSRLNDKQKH---RLDFLQLMIDSQNS--------------KETESH-KALSD 292

  Fly   306 EAITAQAFIFYIAGQETTGSTAAFTIYELAQYPELLKRLQDEVDETLAKNDGKITYDSLNKMEFL 370
            ..:.||:.||..||.|||.|..:||:||||.:|::.::||.|:|..| .|....|||::.:||:|
Human   293 LELAAQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVL-PNKAPPTYDAVVQMEYL 356

  Fly   371 DLCVQETIRKYPGLPILNRECTQDYTVPDTNHV-IPKGTPVVISLYGIHHDAEYFPDPETYDPER 434
            |:.|.||:|.:|....|.|.|.:|..:   |.| ||||:.|||..|.:|||.:|:.:||.:.|||
Human   357 DMVVNETLRLFPVAIRLERTCKKDVEI---NGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPER 418

  Fly   435 FSEESRNYNPTAFMPFGEGPRICIAQRMGRINSKLAIIKILQNFNVEVMSRSEI--EFENSGIAL 497
            ||::..:.:|..:.|||.|||.||..|...:|.|||:|::||||:.:....::|  :.:..|: |
Human   419 FSKKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQGL-L 482

  Fly   498 IPKHGVRVRLSKRVPKLS 515
            .|:..:.:::..|...||
Human   483 QPEKPIVLKVDSRDGTLS 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d4	NP_651082.1	CYP6-like	66..504	CDD:410679	156/461 (34%)
CYP3A5	NP_000768.1	CYP3A	67..491	CDD:410743	156/464 (34%)