DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6d4 and Cyp3a16

DIOPT Version :9

Sequence 1:	NP_651082.1	Gene:	Cyp6d4 / 42682	FlyBaseID:	FBgn0039006	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_031846.2	Gene:	Cyp3a16 / 13114	MGIID:	106099	Length:	504	Species:	Mus musculus

Alignment Length:	545	Identity:	180/545 - (33%)
Similarity:	289/545 - (53%)	Gaps:	92/545 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 SLILLAVTLLTLAWFYLKRHYEY-------WERRGFPFEKHSGIPFGCLDSVWRQEKSM---GLA 57
            :|:|||:.|:.|        |.|       ::::|.|..|  .:||  |.:|....|.:   .:.
Mouse    11 TLVLLAIILVLL--------YRYGTCTHGLFKKQGIPGPK--PLPF--LGTVLNYYKGLWKFDME 63

  Fly    58 IYDVYVKSKERVLGIYLLFRPAVLIRDADLARRVLAQD-FASFHDR------GVYVDEERDPLSA 115
            .|:.|.|:    .|::....|..:|.|.:..:.||.:: |:.|.:|      |:        :|.
Mouse    64 CYEKYGKT----WGLFDGQIPLFVITDPETIKNVLVKECFSVFTNRQDFFPVGI--------MSK 116

  Fly   116 NIFSLRGQSWRSMRHMLSPCFTSGKLKSMFSTSEDIGDKMVAHLQKELPEEGFKEVDIKKVMQNY 180
            :|...:.:.|:..|.:|||.||||.||.||...|..||.:|.:|::| .|:| |.|.:|.|:..|
Mouse   117 SISLAKDEEWKRYRALLSPTFTSGNLKEMFPVIEQYGDILVKYLRQE-AEKG-KPVAVKDVLGAY 179

  Fly   181 AIDIIASTIFGLDVNSFENPDNKFRKLVSLARANNRFNAMFGMMIFLVPSIAQFLFRIGFKNPVG 245
            ::|:|.||.||::::|..||::.|   |..|:...||:....:.:    |:|.|.|.......:.
Mouse   180 SMDVIISTTFGVNIDSLNNPEDPF---VENAKKVLRFDYFDPLSL----SVALFPFLTPIYEMLN 237

  Fly   246 LAMLQIVKETVEY---------------REKHGIVRKDLLQLLIQLRNTGKIDENDEKSFSIQKT 295
            :.|..  |:::|:               ::||   |.|.:.|:::..|         ||    |.
Mouse   238 ICMFP--KDSIEFFKKFVDRMTENRLDSKQKH---RVDFIYLMMEAYN---------KS----KD 284

  Fly   296 PDGHIKTISLEAITAQAFIFYIAGQETTGSTAAFTIYELAQYPELLKRLQDEVDETLAKNDGKIT 360
            .|.| |.:|...||||:.||..||.|||.|..:||:|.||.:|::.|:||:|:||.| .|....|
Mouse   285 KDSH-KALSEIEITAQSIIFIFAGYETTSSILSFTVYSLATHPDIQKKLQEEIDEAL-PNKAPPT 347

  Fly   361 YDSLNKMEFLDLCVQETIRKYPGLPILNRECTQDYTVPDTNHV-IPKGTPVVISLYGIHHDAEYF 424
            ||::..||:||:.:.||:|.||....|.|.|.:|..:   |.: ||||:.|:|..|.:|||.:::
Mouse   348 YDTVMAMEYLDMVLNETLRLYPITNRLQRVCKKDVEI---NGIYIPKGSTVIIPSYVLHHDPQHW 409

  Fly   425 PDPETYDPERFSEESR-NYNPTAFMPFGEGPRICIAQRMGRINSKLAIIKILQNFNVEVMSRSEI 488
            |:||.:.|||||:|:: :.:|..::|||.|||.||..|...:|.|||:||:||||:.:....::|
Mouse   410 PEPEEFQPERFSKENKGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALIKVLQNFSFQPCKETQI 474

  Fly   489 EFENSGIALIPKHGVRVRLSKRVPK 513
            ..:.|...|:  ..|:..:.|.||:
Mouse   475 PLKLSRELLL--QPVKPIVLKVVPR 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d4	NP_651082.1	p450	58..500	CDD:278495	160/465 (34%)
Cyp3a16	NP_031846.2	p450	39..494	CDD:278495	168/504 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820