DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6d4 and CYP3A7-CYP3A51P

DIOPT Version :9

Sequence 1:	NP_651082.1	Gene:	Cyp6d4 / 42682	FlyBaseID:	FBgn0039006	Length:	515	Species:	Drosophila melanogaster
Sequence 2:	NP_001243426.2	Gene:	CYP3A7-CYP3A51P / 100861540	HGNCID:	51504	Length:	535	Species:	Homo sapiens

Alignment Length:	517	Identity:	174/517 - (33%)
Similarity:	275/517 - (53%)	Gaps:	63/517 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ILLAVTLLTLAWFYLKRHYEYWERRGFPFEKHSGIPFGCLDSVWRQEKSMGLAIYDVYVKSKER- 68
            :||||:|: |.:.|..|.:..:::.|.|  ..:.:||  |.:.....|  |...:|:....|.|
Human    13 LLLAVSLI-LLYLYGTRTHGLFKKLGIP--GPTPLPF--LGNALSFRK--GYWTFDMECYKKYRK 70

  Fly    69 VLGIYLLFRPAVLIRDADLARRVLAQD-FASFHDRGVYVDEERDPLS--ANIFSL-RGQSWRSMR 129
            |.|||...:|.:.|.|.|:.:.||.:: ::.|.:|..:     .|:.  .|..|: ..:.|:.:|
Human    71 VWGIYDCQQPMLAITDPDMIKTVLVKECYSVFTNRRPF-----GPVGFMKNAISIAEDEEWKRIR 130

  Fly   130 HMLSPCFTSGKLKSMFSTSEDIGDKMVAHLQKELPEEGFKEVDIKKVMQNYAIDIIASTIFGLDV 194
            .:|||.|||||||.|.......||.:|.:|::| .|.| |.|.:|.|...|::|:|.||.||:.:
Human   131 SLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRRE-AETG-KPVTLKHVFGAYSMDVITSTSFGVSI 193

  Fly   195 NSFENPDNKF----RKLVSLARANNRFNAM--FGMMIFLVPSIAQFLFRIG---FKNPVGLAMLQ 250
            :|..||.:.|    :||:       |||.:  |.:.|.:.|.:...|..:.   |...|...:.:
Human   194 DSLNNPQDPFVENTKKLL-------RFNPLDPFVLSIKVFPFLTPILEALNITVFPRKVISFLTK 251

  Fly   251 IVKETVEYR----EKHGIVRKDLLQLLIQLRNTGKIDENDEKSFSIQKTPDGHIKTISLEAITAQ 311
            .||:..|.|    :||   |.|.|||:|..:|:              |..:.| |.:|...:.||
Human   252 SVKQIKEGRLKETQKH---RVDFLQLMIDSQNS--------------KDSETH-KALSDLELMAQ 298

  Fly   312 AFIFYIAGQETTGSTAAFTIYELAQYPELLKRLQDEVDETLAKNDGKITYDSLNKMEFLDLCVQE 376
            :.||..||.|||.|..:|.|||||.:|::.:::|.|:| |:..|....|||::.::|:||:.|.|
Human   299 SIIFIFAGYETTSSVLSFIIYELATHPDVQQKVQKEID-TVLPNKAPPTYDTVLQLEYLDMVVNE 362

  Fly   377 TIRKYPGLPILNRECTQDYTVPDTNHVIPKGTPVVISLYGIHHDAEYFPDPETYDPERFSEESR- 440
            |:|.:|....|.|.|.:|..:  ....||||..|:|..|.:|||.:|:.:||.:.|||||::::
Human   363 TLRLFPVAMRLERVCKKDVEI--NGMFIPKGVVVMIPSYVLHHDPKYWTEPEKFLPERFSKKNKD 425

  Fly   441 NYNPTAFMPFGEGPRICIAQRMGRINSKLAIIKILQNFNVEVMSRSEI--EFENSGIALIPK 500
            |.:|..:.|||.|||.||..|...:|.|||::::||||:.:....::|  :....|:.|..|
Human   426 NIDPYIYTPFGSGPRNCIGMRFALVNMKLALVRVLQNFSFKPCKETQIPLKLRFGGLLLTEK 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6d4	NP_651082.1	p450	58..500	CDD:278495	158/462 (34%)
CYP3A7-CYP3A51P	NP_001243426.2	p450	39..492	CDD:278495	165/490 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.820