DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cd and Lpo

DIOPT Version :9

Sequence 1:	NP_651081.1	Gene:	cd / 42681	FlyBaseID:	FBgn0263986	Length:	830	Species:	Drosophila melanogaster
Sequence 2:	NP_536345.2	Gene:	Lpo / 76113	MGIID:	1923363	Length:	710	Species:	Mus musculus

Alignment Length:	733	Identity:	223/733 - (30%)
Similarity:	347/733 - (47%)	Gaps:	87/733 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 DEPAAEWALQQAALGHHDGAQAVSAGI-KA-LGDREILEEGLQPNEVNTPSFRHYRSLS-----T 158
            |:|.||..:      .||..:.|...: || |..|:.|:..:      |......|.||     .
Mouse    25 DDPTAETDI------IHDTVEEVKVWVNKAFLDSRDRLKMAM------TTKIHSTRHLSDYLKHA 77

  Fly   159 NPEARKLARRGYVENQATIDIAKRF-NYTKQP-GRSNIGWGPKIVLPDPTVLRLECDFNARYRRS 221
            ....|...|.|.|..::...:::.. |.|.|. ..:.:.|......|.||   :.|:.::.||..
Mouse    78 KGRTRTAIRSGQVWEESLKKLSQFLTNVTGQGLDLTLLSWEAGCDPPAPT---MTCNISSPYRTI 139

  Fly   222 TGVCNNKQHPRTYGASMVPYRRMVSPDYADGIAAP------RVSHHGRLPPARQVSLKIHRSSYE 280
            ||.|||:::| ..|::.....|.:..:|.||::.|      ::.:...||..|:||.:|.....|
Mouse   140 TGYCNNRKNP-ALGSANRALARWLPAEYEDGLSLPYGWTPGKMRNGFPLPQPREVSNQIAAYLNE 203

  Fly   281 ---TDSNFTVMLAVFGQFMDHDI-----TATSLTTSQEGESIDCCVAATREQHPECYPVDILPDD 337
               .|...:::...:||.:|||:     |.....|..:.:..:.|:     |...|:|:...|.|
Mouse   204 EDVLDQKRSMLFMQWGQIVDHDMDFAPETEMGSDTYTKAQCDEHCI-----QGDNCFPIMFPPGD 263

  Fly   338 PYYKQYNISCMNFVRS---APAPTGRFGPRMQLNQATAFIDASVVYGNLEQRQNQLRSFINGSLR 399
            |..|... .||.|.|:   .|.|..:...|.|:|..|:|:|||:||.......|:||: ::..|.
Mouse   264 PKLKTQG-KCMPFFRAGFVCPTPPYKSLAREQINALTSFLDASLVYSPEPSLANRLRN-LSSPLG 326

  Fly   400 MF-----VTDDGRQLLPISSNPADGCNRVQMTRLGKYCFESGDDRANENLLLTSMHLLWARHHNY 459
            :.     |:|:||...|........|..:..| .|..||.:||.||:|.:||.:.|.|:.|.||.
Mouse   327 LMAVNEEVSDNGRPFPPFVKMKPSPCEVINAT-AGVPCFLAGDSRASEQILLATSHTLFIREHNR 390

  Fly   460 LARQLQEQNPHWEDERLYQEARKILGAQMAHITYNEFLPVLLGKNISEAKGLLPAKHNLNAPDTY 524
            ||.:|...||||:.|.||||||||:||.:...|:.::||:|||   .|.:..:|....      |
Mouse   391 LATELSRLNPHWDRETLYQEARKIMGAFIQITTFRDYLPILLG---DEMQKWIPPYQG------Y 446

  Fly   525 DPEVDPSIANCFAAAAFRFAHTLLPGLFNISRDNSTP----EAIELHKMLFNPFSLWAEHGIDHA 585
            :..|||.|:|.| ..|.||.|..:|.......:|..|    ..:.||.:.||.:.|..:.|||..
Mouse   447 NESVDPRISNVF-TFALRFGHLEIPSTVYRLDENYQPWGSESELPLHTVFFNTWRLVKDGGIDPL 510

  Fly   586 L--MTAANTPVMQVDRFFSLEVTQKLFEGTAEDRVPLCGLDLVSLNIQRGRDHGIPSYPVFRRHC 648
            :  :.|.|..:|..::..:.|:..|||    :....:.|.||.|:||||.||||.|.|..:|..|
Mouse   511 VRGLLAKNAKLMHQNKMMTGELRNKLF----QPNHTIHGFDLASINIQRSRDHGQPGYNSWRAFC 571

  Fly   649 RLPTVDTWEEMSQAIDNATL-DSIRQIYESPQDVDVYTGALSEPPLDGAIFGPLLSCMVSDQFLR 712
            .|....|.||:|..:.|..| ..:..:|.:|.::|::.||::||.:.....||||:|::..||.|
Mouse   572 GLSQPKTLEELSAVMKNEVLAKKLMDLYGTPSNIDIWLGAVAEPLVHRGRVGPLLTCLLGQQFQR 636

  Fly   713 LKLGDSHWYERKMGPQKFTKAQLAEIYKTSLAAIICRNSDGITRVREHVMQRLRDGGNPH--VDC 775
            ::.||..|:|   .|..||:.|...:.|.|.:.::|.|: ||.:|..:..|.   ...||  |||
Mouse   637 IRDGDRFWWE---NPGVFTEKQRESLQKMSFSRLVCDNT-GIDKVPLNPFQA---NAYPHGFVDC 694

  Fly   776 QDLEGFHFNFEPWSEKQQ 793
            ..::  ..:..||:..::
Mouse   695 SSID--KLDLSPWASVKE 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cd	NP_651081.1	An_peroxidase	218..755	CDD:281139	185/565 (33%)
cd	NP_651081.1	peroxinectin_like	364..750	CDD:188655	140/397 (35%)
Lpo	NP_536345.2	myeloperoxidase_like	281..692	CDD:188656	149/433 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	310	1.000	Inparanoid score	I2576
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.860